内质网应激是细胞的重要防御机制,最大限度地对抗内外源性的应激,应激可激活下游信号使得蛋白折叠功能恢复或细胞死亡,持续高强度的内质网应激则会触发程序性细胞死亡或者是凋亡。在溃疡性结肠炎的发生发展中内质网应激发挥了重要作用...内质网应激是细胞的重要防御机制,最大限度地对抗内外源性的应激,应激可激活下游信号使得蛋白折叠功能恢复或细胞死亡,持续高强度的内质网应激则会触发程序性细胞死亡或者是凋亡。在溃疡性结肠炎的发生发展中内质网应激发挥了重要作用。现对内质网应激在溃疡性结肠炎中的研究进展进行综述,为溃疡性结肠炎的治疗提供新思路。Endoplasmic reticulum stress is an important defense mechanism of cells, which can maximize the resistance to internal and external stress. Stress can activate downstream signals to restore protein folding function or cell death, and sustained high intensity endoplasmic reticulum stress can trigger programmed cell death or apoptosis. Endoplasmic reticulum stress plays an important role in the occurrence and development of ulcerative colitis. This article reviews the research progress of endoplasmic reticulum stress in ulcerative colitis, and provides a new idea for the treatment of ulcerative colitis.展开更多
文摘内质网应激是细胞的重要防御机制,最大限度地对抗内外源性的应激,应激可激活下游信号使得蛋白折叠功能恢复或细胞死亡,持续高强度的内质网应激则会触发程序性细胞死亡或者是凋亡。在溃疡性结肠炎的发生发展中内质网应激发挥了重要作用。现对内质网应激在溃疡性结肠炎中的研究进展进行综述,为溃疡性结肠炎的治疗提供新思路。Endoplasmic reticulum stress is an important defense mechanism of cells, which can maximize the resistance to internal and external stress. Stress can activate downstream signals to restore protein folding function or cell death, and sustained high intensity endoplasmic reticulum stress can trigger programmed cell death or apoptosis. Endoplasmic reticulum stress plays an important role in the occurrence and development of ulcerative colitis. This article reviews the research progress of endoplasmic reticulum stress in ulcerative colitis, and provides a new idea for the treatment of ulcerative colitis.
