AIM： To study the antiviral effect of Chinese medicine jiaweisinisan （JWSNS） on hepatitis B virus （HBV） infection in transgenic mice （TGM）. METHODS： Twenty two 6-8 wk old HBV TGM in the third generation were d...AIM： To study the antiviral effect of Chinese medicine jiaweisinisan （JWSNS） on hepatitis B virus （HBV） infection in transgenic mice （TGM）. METHODS： Twenty two 6-8 wk old HBV TGM in the third generation were divided into TGM control group and TGM treated group randomly. The normal control group included ten normal BC 57L/6 mice at the same age. The mice in treated group were administrated with JWSNS at the concentration of 4 g/mL and the dosage of 50 g/kg per d for 30 d, while the mice in TGM control group and normal control group were administrated with normal saline at the same dosage and the same time. Polymerase chain reaction （PCR） was used to assess the contents of HBV DNA in serum of HBV TGM before and after treatments, whereas blot hybridization was utilized to measure the contents of HBV DNA in the liver of both HBV TGM and normal BC 57L/6 mice. RESULTS： The levels of serum HBV DNA in TGM treated group were remarkably decreased after the treatment of JWSNS （7.662±0.78 vs 5.22±3.14, P〈0.05）, while there was no obvious change after administration of normal saline in TGM control group （7.125±4.26 vs 8.932 ± 5.12, P〉 0.05）. The OD values of HBV DNA in the livers of the mice in TGM treated group were significantly lower than those of TGM control group （0.274±0.096 vs 0.432 ± 0.119, P 〈 0.01）. CONCLUSION： JWSNS exerts suppressive effects on HBV DNA in the serum and liver of TGM.展开更多
Traditional Chinese medicines(TCMs)have been used to prevent and treat various diseases for thousands of years.Promoting efficacy and reducing toxicity by the compatibility theory of TCMs has attracted increasing atte...Traditional Chinese medicines(TCMs)have been used to prevent and treat various diseases for thousands of years.Promoting efficacy and reducing toxicity by the compatibility theory of TCMs has attracted increasing attention,especially for the toxicity of herbs.Studies have pointed out the interactions between the active compounds of herbs and transporters in the detoxification process of toxic compounds.Here,we summarize data on five toxic herbs commonly used in TCMs and their related efflux transporters to reduce toxicity to offer a scientific rationale for the compatibility principle of TCMs and provide guidance for the rational clinical use of TCMs.展开更多
The results of field tests of the catalyst ＂Mukhamedzhan-l＂ for the detoxification of propellant UDMH （unsymmetrical dimethylhydrazine） in the position the space center ＂Baikonur＂ in Kazakhstan were studied. Res...The results of field tests of the catalyst ＂Mukhamedzhan-l＂ for the detoxification of propellant UDMH （unsymmetrical dimethylhydrazine） in the position the space center ＂Baikonur＂ in Kazakhstan were studied. Results of field tests have shown high efficiency of the catalyst ＂Mukhamedzhan- 1＂ for detoxification UDMH.展开更多
Glucocorticoid(GC) plays an important role in anti-inflammatory,anti-allergic effects and immunosuppression,and has become a widely used drug in clinical departments.However,GC also produces a number of serious side e...Glucocorticoid(GC) plays an important role in anti-inflammatory,anti-allergic effects and immunosuppression,and has become a widely used drug in clinical departments.However,GC also produces a number of serious side effects at the same time.After GC acting on human body,the syndrome change has some regular pattern and it can be treated on the basis of syndrome differentiation and stage to aim at further improving therapeutic efficacy.The Chinese medicine can reduce the side effects of GC when treating the primary disease,thus plays a role in Synergism and Detoxification.展开更多
基金Supported by the National Natural Science Foundation of China, No. 30000217 and the Natural Science Foundation of Guangdong Province, No. 000359 and No. 2005B30101012
文摘AIM： To study the antiviral effect of Chinese medicine jiaweisinisan （JWSNS） on hepatitis B virus （HBV） infection in transgenic mice （TGM）. METHODS： Twenty two 6-8 wk old HBV TGM in the third generation were divided into TGM control group and TGM treated group randomly. The normal control group included ten normal BC 57L/6 mice at the same age. The mice in treated group were administrated with JWSNS at the concentration of 4 g/mL and the dosage of 50 g/kg per d for 30 d, while the mice in TGM control group and normal control group were administrated with normal saline at the same dosage and the same time. Polymerase chain reaction （PCR） was used to assess the contents of HBV DNA in serum of HBV TGM before and after treatments, whereas blot hybridization was utilized to measure the contents of HBV DNA in the liver of both HBV TGM and normal BC 57L/6 mice. RESULTS： The levels of serum HBV DNA in TGM treated group were remarkably decreased after the treatment of JWSNS （7.662±0.78 vs 5.22±3.14, P〈0.05）, while there was no obvious change after administration of normal saline in TGM control group （7.125±4.26 vs 8.932 ± 5.12, P〉 0.05）. The OD values of HBV DNA in the livers of the mice in TGM treated group were significantly lower than those of TGM control group （0.274±0.096 vs 0.432 ± 0.119, P 〈 0.01）. CONCLUSION： JWSNS exerts suppressive effects on HBV DNA in the serum and liver of TGM.
基金We thank for the funding support from the Science and Technology Development Fund,Macao SAR(No.0040/2020/A and No.0075/2019/AMJ).
文摘Traditional Chinese medicines(TCMs)have been used to prevent and treat various diseases for thousands of years.Promoting efficacy and reducing toxicity by the compatibility theory of TCMs has attracted increasing attention,especially for the toxicity of herbs.Studies have pointed out the interactions between the active compounds of herbs and transporters in the detoxification process of toxic compounds.Here,we summarize data on five toxic herbs commonly used in TCMs and their related efflux transporters to reduce toxicity to offer a scientific rationale for the compatibility principle of TCMs and provide guidance for the rational clinical use of TCMs.
文摘The results of field tests of the catalyst ＂Mukhamedzhan-l＂ for the detoxification of propellant UDMH （unsymmetrical dimethylhydrazine） in the position the space center ＂Baikonur＂ in Kazakhstan were studied. Results of field tests have shown high efficiency of the catalyst ＂Mukhamedzhan- 1＂ for detoxification UDMH.
基金Supported by Projects in the National Science & Technology Pillar Program in the Eleventh Five-year Plan Period (No. 2006BA104A10)State Traditional Chinese Medicine Department Research Foundation (No. 200707016)National Natural Science Foundation of China (No. 81072764)
文摘Glucocorticoid(GC) plays an important role in anti-inflammatory,anti-allergic effects and immunosuppression,and has become a widely used drug in clinical departments.However,GC also produces a number of serious side effects at the same time.After GC acting on human body,the syndrome change has some regular pattern and it can be treated on the basis of syndrome differentiation and stage to aim at further improving therapeutic efficacy.The Chinese medicine can reduce the side effects of GC when treating the primary disease,thus plays a role in Synergism and Detoxification.
