A new triterpenoid, methyl buergericate (12a), which was elucidated as 2 alpha, 3 alpha, 19 alpha, 24-tetrahydroxyl olean-12-en-28-oic acid methyl ester by spectroscopic methods, together with eleven known triterpenoi...A new triterpenoid, methyl buergericate (12a), which was elucidated as 2 alpha, 3 alpha, 19 alpha, 24-tetrahydroxyl olean-12-en-28-oic acid methyl ester by spectroscopic methods, together with eleven known triterpenoids was isolated from Rubus buergeri Miq. The isolation of the above chemical constituents from this plant was reported for the first time.展开更多
Curative compositions such as catolpol in Rehmannia Glutinosa, flavone in Ophiopogon Japonicus and ginsenoside Re in Panax Ginseng in Chinese herbs were measured as the experimental indices by the method of high perfo...Curative compositions such as catolpol in Rehmannia Glutinosa, flavone in Ophiopogon Japonicus and ginsenoside Re in Panax Ginseng in Chinese herbs were measured as the experimental indices by the method of high performance liquid chromatography under different drying conditions. The reaction order and parameters of the degradation kinetics model were determined and the model was verified by experiments. It was indicated that by comparing with the thin drying method, the prospective model could predict the degradation of curative compositions with drying time, temperature and moisture content of herbal materials with enough precision and could be used to simulate the degradation in the drying process of Chinese herb.展开更多
As the fifth most common cancer and the third most comxnon cause of cancer deaths worldwide, gastric cancer remains a significant public health concern and an economic burden in developed and developing countries. Gas...As the fifth most common cancer and the third most comxnon cause of cancer deaths worldwide, gastric cancer remains a significant public health concern and an economic burden in developed and developing countries. Gastric inflammation induced by Helicobacter pylori may initiate superficial gastritis, which then progresses to atrophic gastritis, gastric epithelial dysplasia, and finally gastric cancer. The pathogenesis of AT. pylori infection is related to its virulence factors, including urease, flagella, vacuolating cytotoxin A and cytotoxin-associated gene antigen. The relevant mechanisms of H. pylori-induced inflammation include activation of nuclear factor-r,B, mitogen-acfivated protein kinase pathway, and oxidative stress. To date, therapeutic strategies and results in this infection remain undesirable. Complicated treatment issues include antibiotic resistance, adverse effects of chemical drugs, and recurrence after operation. Therefore, chemoprevention has been regarded as an important measure, and Chinese medicinal herbs have been the research hotspot. This review aimed to summarize the effects of Chinese medicinal herbs on the prevention of gastric cancer, mechanism of action and the treatment prospects, with emphasis H. pylori-induced effects.展开更多
文摘A new triterpenoid, methyl buergericate (12a), which was elucidated as 2 alpha, 3 alpha, 19 alpha, 24-tetrahydroxyl olean-12-en-28-oic acid methyl ester by spectroscopic methods, together with eleven known triterpenoids was isolated from Rubus buergeri Miq. The isolation of the above chemical constituents from this plant was reported for the first time.
文摘Curative compositions such as catolpol in Rehmannia Glutinosa, flavone in Ophiopogon Japonicus and ginsenoside Re in Panax Ginseng in Chinese herbs were measured as the experimental indices by the method of high performance liquid chromatography under different drying conditions. The reaction order and parameters of the degradation kinetics model were determined and the model was verified by experiments. It was indicated that by comparing with the thin drying method, the prospective model could predict the degradation of curative compositions with drying time, temperature and moisture content of herbal materials with enough precision and could be used to simulate the degradation in the drying process of Chinese herb.
基金Natural Science Foundation of China(Grant No.81120108025)the Science and Technology Department of Guangzhou City(Grant No.201509010004)
文摘As the fifth most common cancer and the third most comxnon cause of cancer deaths worldwide, gastric cancer remains a significant public health concern and an economic burden in developed and developing countries. Gastric inflammation induced by Helicobacter pylori may initiate superficial gastritis, which then progresses to atrophic gastritis, gastric epithelial dysplasia, and finally gastric cancer. The pathogenesis of AT. pylori infection is related to its virulence factors, including urease, flagella, vacuolating cytotoxin A and cytotoxin-associated gene antigen. The relevant mechanisms of H. pylori-induced inflammation include activation of nuclear factor-r,B, mitogen-acfivated protein kinase pathway, and oxidative stress. To date, therapeutic strategies and results in this infection remain undesirable. Complicated treatment issues include antibiotic resistance, adverse effects of chemical drugs, and recurrence after operation. Therefore, chemoprevention has been regarded as an important measure, and Chinese medicinal herbs have been the research hotspot. This review aimed to summarize the effects of Chinese medicinal herbs on the prevention of gastric cancer, mechanism of action and the treatment prospects, with emphasis H. pylori-induced effects.
