AIM To evaluate the short-and long-term results of endoscopic ultrasound-guided transmural drainage(EUS-GTD) for pancreatic fluid collection(PFC) and identify the predictive factors of treatment outcome for walled-off...AIM To evaluate the short-and long-term results of endoscopic ultrasound-guided transmural drainage(EUS-GTD) for pancreatic fluid collection(PFC) and identify the predictive factors of treatment outcome for walled-off necrosis(WON) managed by EUS-GTD alone.METHODS We investigated 103 consecutive patients with PFC who underwent EUS-GTD between September 1999 and August 2015. Patients were divided into four groups as follows: WON(n = 40), pancreatic pseudocyst(PPC; n = 11), chronic pseudocyst(n = 33), and others(n = 19). We evaluated the short-and long-term outcomes of the treatment. In cases of WON, multiple logistic regression analyses were performed to identify the predictor variables associated with the treatment success. In addition, PFC recurrence was examined in patients followed up for more than 6 mo and internal stent removal after successful EUS-GTD was confirmed.RESULTS In this study, the total technical success rate was 96.1%. The treatment success rate of WON, PPC, chronic pseudocyst, and others was 57.5%, 90.9%, 91.0%, and 89.5%, respectively. Contrast-enhanced computed tomography using the multivariate logistic regression analysis revealed that the treatment success rate of WON was significantly lower in patients with more than 50% pancreatic parenchymal necrosis(OR = 17.0; 95%CI: 1.9-150.7; P = 0.011) and in patients with more than 150 mm of PFC(OR = 27.9; 95%CI: 3.4-227.7; P = 0.002).The recurrence of PFC in the long term was 13.3%(median observation time, 38.8 mo). Mean amylase level in the cavity was significantly higher in the recurrence group than in the no recurrence group(P = 0.02).CONCLUSION The reduction of WON by EUS-GTD alone was associated with the proportion of necrotic tissue and extent of the cavity. The amylase level in the cavity may be a predictive factor for recurrence of PFC.展开更多
目的分析比较基于决定因素分类(determinant-based classification, DBC),修订后的亚特兰大分类(Revision of Atlanta classification, RAC)与亚特兰大分类标准(Atlanta classification, AC)的三者对急性胰腺炎(acute pancreatitis, AP...目的分析比较基于决定因素分类(determinant-based classification, DBC),修订后的亚特兰大分类(Revision of Atlanta classification, RAC)与亚特兰大分类标准(Atlanta classification, AC)的三者对急性胰腺炎(acute pancreatitis, AP)严重程度的分层效能以及不同严重程度与临床预后之间的关系。方法回顾性分析2015年1月至2017年12月安徽医科大学第二附属医院急诊外科收治的458例急性胰腺炎患者病历资料。分别使用DBC、RAC与AC三种分类标准对其进行重新分类,分析比较三种标准的分层效能。通过ROC曲线比较三种分类标准预测临床结局准确度。采用多因素Logistic回归分析AP死亡的独立危险因素。结果(1)三种分类标准中,各亚型间的死亡率、侵入性治疗率、ICU监护率、ICU监护时间以及平均住院时间差异存在统计学意义(P < 0.001)。(2) DBC、RAC与AC在对死亡(AUC 0.94和0.95 vs 0.63, P < 0.01)、ICU监护(AUC 0.90和0.88 vs 0.60, P < 0.001)的预测比较上,DBC与RAC准确度相当,但均优于AC;对侵入性操作(AUC 0.88 vs 0.69和0.68, P < 0.001)的预测上,DBC的准确度则更优于RAC与AC。(3)持续性器官功能衰竭(OR = 13.131, P = 0.003)与感染性坏死(OR = 9.424, P = 0.014)为AP死亡的独立危险因素。结论 DBC与RAC对AP的严重程度的分层能力显著优于AC。DBC对临床结局的预测准确度优于RAC与AC。感染性坏死与持续性器官功能衰竭均是AP死亡的独立危险因素。展开更多
文摘AIM To evaluate the short-and long-term results of endoscopic ultrasound-guided transmural drainage(EUS-GTD) for pancreatic fluid collection(PFC) and identify the predictive factors of treatment outcome for walled-off necrosis(WON) managed by EUS-GTD alone.METHODS We investigated 103 consecutive patients with PFC who underwent EUS-GTD between September 1999 and August 2015. Patients were divided into four groups as follows: WON(n = 40), pancreatic pseudocyst(PPC; n = 11), chronic pseudocyst(n = 33), and others(n = 19). We evaluated the short-and long-term outcomes of the treatment. In cases of WON, multiple logistic regression analyses were performed to identify the predictor variables associated with the treatment success. In addition, PFC recurrence was examined in patients followed up for more than 6 mo and internal stent removal after successful EUS-GTD was confirmed.RESULTS In this study, the total technical success rate was 96.1%. The treatment success rate of WON, PPC, chronic pseudocyst, and others was 57.5%, 90.9%, 91.0%, and 89.5%, respectively. Contrast-enhanced computed tomography using the multivariate logistic regression analysis revealed that the treatment success rate of WON was significantly lower in patients with more than 50% pancreatic parenchymal necrosis(OR = 17.0; 95%CI: 1.9-150.7; P = 0.011) and in patients with more than 150 mm of PFC(OR = 27.9; 95%CI: 3.4-227.7; P = 0.002).The recurrence of PFC in the long term was 13.3%(median observation time, 38.8 mo). Mean amylase level in the cavity was significantly higher in the recurrence group than in the no recurrence group(P = 0.02).CONCLUSION The reduction of WON by EUS-GTD alone was associated with the proportion of necrotic tissue and extent of the cavity. The amylase level in the cavity may be a predictive factor for recurrence of PFC.
文摘目的分析比较基于决定因素分类(determinant-based classification, DBC),修订后的亚特兰大分类(Revision of Atlanta classification, RAC)与亚特兰大分类标准(Atlanta classification, AC)的三者对急性胰腺炎(acute pancreatitis, AP)严重程度的分层效能以及不同严重程度与临床预后之间的关系。方法回顾性分析2015年1月至2017年12月安徽医科大学第二附属医院急诊外科收治的458例急性胰腺炎患者病历资料。分别使用DBC、RAC与AC三种分类标准对其进行重新分类,分析比较三种标准的分层效能。通过ROC曲线比较三种分类标准预测临床结局准确度。采用多因素Logistic回归分析AP死亡的独立危险因素。结果(1)三种分类标准中,各亚型间的死亡率、侵入性治疗率、ICU监护率、ICU监护时间以及平均住院时间差异存在统计学意义(P < 0.001)。(2) DBC、RAC与AC在对死亡(AUC 0.94和0.95 vs 0.63, P < 0.01)、ICU监护(AUC 0.90和0.88 vs 0.60, P < 0.001)的预测比较上,DBC与RAC准确度相当,但均优于AC;对侵入性操作(AUC 0.88 vs 0.69和0.68, P < 0.001)的预测上,DBC的准确度则更优于RAC与AC。(3)持续性器官功能衰竭(OR = 13.131, P = 0.003)与感染性坏死(OR = 9.424, P = 0.014)为AP死亡的独立危险因素。结论 DBC与RAC对AP的严重程度的分层能力显著优于AC。DBC对临床结局的预测准确度优于RAC与AC。感染性坏死与持续性器官功能衰竭均是AP死亡的独立危险因素。
