期刊文献+
共找到12篇文章
< 1 >
每页显示 20 50 100
GZR-98体内抗炎作用研究
1
作者 白金叶 关慕贞 +2 位作者 刘柏合 李怡棠 程桂芳 《中国药理通讯》 2003年第3期54-55,共2页
关键词 GZR-98 体内抗炎作用 小鼠 肉芽肿 急性
下载PDF
广西地桃花水提物的急性毒性和体内抗炎作用的研究 被引量:8
2
作者 蒙小菲 黄振光 +2 位作者 杨玉芳 覃巧 黄小理 《广西医科大学学报》 CAS 2015年第6期901-904,共4页
目的:了解广西地桃花水提物的急性毒性及其体内抗炎作用。方法:小鼠灌胃给药,通过测定地桃花水提物最大给药量(MLD)进行急性毒性试验。采用二甲苯致小鼠耳廓肿胀、角叉菜胶致小鼠足趾肿胀模型,观察地桃花水提物对急性炎症模型的影响。... 目的:了解广西地桃花水提物的急性毒性及其体内抗炎作用。方法:小鼠灌胃给药,通过测定地桃花水提物最大给药量(MLD)进行急性毒性试验。采用二甲苯致小鼠耳廓肿胀、角叉菜胶致小鼠足趾肿胀模型,观察地桃花水提物对急性炎症模型的影响。实验动物分别设立空白对照组、阳性对照组(地塞米松10 mg/kg)和地桃花水提物3个给药剂量组(10g/kg、20g/kg、40g/kg),分别测定地桃花水提物对小鼠耳廓肿胀、足趾肿胀的抑制率。结果:急性毒性试验灌胃给药后,无一小鼠死亡,地桃花水提物MLD为240g/kg(折合生药含量)。与空白对照组相比,地桃花水提物高、中、低剂量组均能抑制二甲苯致小鼠耳廓肿胀(P<0.05,P<0.01),耳廓肿胀抑制率分别为39.12%、24.09%、23.06%;地桃花水提物高、中剂量组能抑制角叉菜胶致小鼠足趾肿胀(P<0.05,P<0.01),足趾肿胀抑制率分别为40.23%、21.76%。结论:地桃花水提取物没有明显毒性;地桃花水提物可抑制二甲苯致小鼠耳廓肿胀、角叉菜胶致小鼠足趾肿胀。 展开更多
关键词 地桃花水提物 急性毒性 体内抗炎 耳廓肿胀 足趾肿胀
下载PDF
斑籽木乙酸乙酯萃取部位的体内外抗炎作用及机制
3
作者 杨锐 卢光衣 +3 位作者 张倩茹 陈帅 何红平 蒋华夷 《山东医药》 CAS 2023年第7期42-46,共5页
目的探讨斑籽木乙酸乙酯萃取部位(BSEA)的体内外抗炎作用及机制。方法将48只雌性小鼠随机分为正常对照组、模型组、阳性对照组及BSEA高、中、低剂量组。阳性对照组给予阿司匹林400 mg/kg灌胃,BSEA高、中、低剂量组分别给予176、88、44 m... 目的探讨斑籽木乙酸乙酯萃取部位(BSEA)的体内外抗炎作用及机制。方法将48只雌性小鼠随机分为正常对照组、模型组、阳性对照组及BSEA高、中、低剂量组。阳性对照组给予阿司匹林400 mg/kg灌胃,BSEA高、中、低剂量组分别给予176、88、44 mg/kg浸膏灌胃,模型组给予等体积0.5%羧甲基纤维素钠溶液灌胃,均每天1次,连续灌胃5 d。用角叉菜胶制备小鼠足跖肿胀模型,以足跖肿胀度、足跖肿胀抑制率为观察指标,分析BSEA的体内抗炎作用;对BSEA进行分离纯化,根据波谱数据鉴定化合物结构,观察化合物对脂多糖(LPS)诱导的小鼠RAW264.7巨噬细胞内一氧化氮(NO)生成的抑制作用,评价单体成分的体外抗炎活性;用分子对接技术分析活性成分的抗炎作用机制。结果连续灌胃给药5 d,小鼠未出现异常,表明受试样品在实验所设定的剂量条件下对小鼠的正常生命活动无影响。与模型组比较,阳性对照组、BSEA高剂量组、BSEA中剂量组足肿胀度低(P均<0.05);与阳性对照组比较,BSEA中、低剂量组足肿胀度高(P均<0.05),而高剂量组足肿胀度与阳性对照组比较差异无统计学意义(P>0.05)。阳性对照组及BSEA高、中、低剂量组肿胀抑制率分别为45.56%、35.57%、27.24%、14.19%。从斑籽木BSEA中分离得到4个化合物,分别鉴定为2,3-反式-6,7,4′-三甲氧基黄烷醇(1)、α-亚麻酸(2)、亚麻酸甲酯(3)、甘油亚麻酸酯(4);化合物2对LPS诱导的RAW264.7细胞内NO的生成有一定抑制作用,半数抑制浓度为(22.79±1.48)μmol/L,且其与炎症相关靶标诱导型一氧化氮合酶(iNOS)、过氧化物酶体增长物激活受体α(PPARα)、核转录因子-κB(NF-κB)、白细胞介素-1β(IL-1β)、肿瘤坏死因子-α(TNF-α)具有较好的亲和力,结合能分别为-7.3、-6.7、-6.4、-6.2、-5.9 kCal/mol。结论BSEA具有较好的体内外抗炎作用,首次从中分离得到化合物1~4,化合物2具有潜在的抗炎作用,其可能通过iNOS、PPARα、NF-κB、IL-1β、TNF-α发挥抗炎作用。 展开更多
关键词 斑籽木 乙酸乙酯萃取部位 体内抗炎作用 体外作用
下载PDF
益康唑莪术油复方制剂抗炎作用的实验研究 被引量:1
4
作者 刘勇 刘建华 +1 位作者 张智洁 孙继梅 《中国临床药理学杂志》 CAS CSCD 北大核心 2006年第2期119-121,共3页
目的研究益康唑莪术油复方制剂(抗阴道炎药)抗炎作用。方法将♀大鼠随机分组,建立阴道白色念珠菌、大肠杆菌、金黄色葡萄球菌感染模型,分别给予双唑泰栓(阳性对照)、益康唑莪术油复方制剂3个剂量组,每天给药1次,连用7天;以阴道菌培养菌... 目的研究益康唑莪术油复方制剂(抗阴道炎药)抗炎作用。方法将♀大鼠随机分组,建立阴道白色念珠菌、大肠杆菌、金黄色葡萄球菌感染模型,分别给予双唑泰栓(阳性对照)、益康唑莪术油复方制剂3个剂量组,每天给药1次,连用7天;以阴道菌培养菌落数和阴道组织炎细胞浸润程度为观察指标。结果益康唑莪术油复方制剂对大鼠阴道感染白色念珠菌、大肠杆菌、金黄色葡萄球菌有明显治疗作用,2个剂量组(648,324mg·kg-1)和阳性对照药均与赋形剂对照组比较,均有显著性差异(P<0.05)。结论益康唑莪术油复方制剂可明显降低大鼠阴道感染白色念珠菌、大肠杆菌、金黄色葡萄球菌的数量,明显降低阴道组织炎细胞浸润程度,对阴道正常菌群无明显影响。 展开更多
关键词 益康唑莪术油复方制剂 赋形剂 体内抗炎
下载PDF
车叶草苷体外抗炎作用机理的初步探讨 被引量:2
5
作者 丁晓瑜 李斌 +3 位作者 程桂芳 白金叶 关慕贞 侯琦 《中国药理通讯》 2010年第2期48-49,共2页
目的:在体外采用巴豆油所致的小鼠耳肿胀、角叉菜胶所致的大鼠足肿胀等急性炎症模型研究了车叶草苷的体内抗炎作用的基础上,观察长尾粗叶木中的环烯醚萜类成分的体外抗炎作用,并对其抗炎作用机理进行了初步探讨,方法:本研究采用多... 目的:在体外采用巴豆油所致的小鼠耳肿胀、角叉菜胶所致的大鼠足肿胀等急性炎症模型研究了车叶草苷的体内抗炎作用的基础上,观察长尾粗叶木中的环烯醚萜类成分的体外抗炎作用,并对其抗炎作用机理进行了初步探讨,方法:本研究采用多种色谱方法对长尾粗叶木茎叶95%乙醇提取物进行了化学成分分离,利用现代波谱方法对化学成分分离,体外建立脂多糖激活的小鼠腹腔巨噬细胞炎症模型,初步探讨车叶草苷的抗炎作用。 展开更多
关键词 作用机理 体外 小鼠腹腔巨噬细胞 急性症模型 化学成分分离 长尾粗叶木 体内抗炎作用
下载PDF
抗病毒口服液药效研究
6
作者 杨鹊 曾琳玲 +2 位作者 梁惠婵 张灿莲 欧慧瑜 《中国药理通讯》 2004年第3期59-59,共1页
关键词 病毒口服液 药效学 体外菌活性 体内抗炎效果 中药制剂
下载PDF
NSAIDs for prevention of pancreatitis after endoscopic retrograde cholangiopancreatography:Ready for prime time? 被引量:22
7
作者 Mansour A Parsi 《World Journal of Gastroenterology》 SCIE CAS CSCD 2012年第30期3936-3937,共2页
Acute pancreatitis is the most common and the most fearful complication of endoscopic retrograde cholangiopancreatography (ERCP).Prevention of post-ERCP pancreatitis has therefore been of great interest to endoscopist... Acute pancreatitis is the most common and the most fearful complication of endoscopic retrograde cholangiopancreatography (ERCP).Prevention of post-ERCP pancreatitis has therefore been of great interest to endoscopists performing ERCP procedures.So far,only pancreatic duct stenting during ERCP and rectal administration of a non-steroidal anti-inflammatory drug (NSAID) prior to or immediately after ERCP have been consistently shown to be effective for prevention of post-ERCP pancreatitis.This commentary focuses on a short discussion about the rates,mechanisms,and risk factors for post-ERCP pancreatitis,and effective means for its prevention with emphasis on the use of NSAIDs including a recent clinical trial published in The New England Journal of Medicine by Elmunzer et al. 展开更多
关键词 Endoscopic retrograde cholangiopancreatography Pancreatitis Post-endoscopic retrograde cholangiopancreatography pancreatitis Pancreatic stents Non-steroidal anti-inflammatory drugs
下载PDF
Single center experience of capsule endoscopy in patients with obscure gastrointestinal bleeding 被引量:40
8
作者 Mahesh Kumar Goenka Shounak Majumder +2 位作者 Sanjeev Kumar Pradeepta Kumar Sethy Usha Goenka 《World Journal of Gastroenterology》 SCIE CAS CSCD 2011年第6期774-778,共5页
AIM:To identify optimum timing to maximize diagnostic yield by capsule endoscopy (CE) in patients with obscure gastrointestinal bleeding (OGIB).METHODS:We identified patients who underwent CE at our institution from A... AIM:To identify optimum timing to maximize diagnostic yield by capsule endoscopy (CE) in patients with obscure gastrointestinal bleeding (OGIB).METHODS:We identified patients who underwent CE at our institution from August 2003 to December 2009.Patient medical records were reviewed to determine type of OGIB (occult,overt),CE results and complications,and timing of CE with respect to onset of bleeding.RESULTS:Out of 385 patients investigated for OGIB,284 (74%) had some lesion detected by CE.In 222 patients (58%),definite lesions were detected that could unequivocally explain OGIB.Small bowel ulcer/erosions secondary to Crohn's disease,tuberculosis or non-steroidal anti-inflammatory agent use were the commonest lesions detected.Patients with overt GI bleeding for < 48 h before CE had the highest diagnostic yield (87%).This was significantly greater (P < 0.05) compared to that in patients with overt bleeding prior to 48 h (68%),as well as those with occult OGIB (59%).CONCLUSION:We established the importance of early CE in management of OGIB.CE within 48 h of overt bleeding has the greatest potential for lesion detection. 展开更多
关键词 Capsule endoscopy Gastrointestinal bleeding
下载PDF
YMDD mutations in patients with chronic hepatitis B untreated with antiviral medicines 被引量:9
9
作者 Zhong-MinHuang Qi-WenHuang Ya-QinQin Yan-ZhuanHe Hou-JiQin Yiao-NanZhou XiangXu Mei-JinHuang 《World Journal of Gastroenterology》 SCIE CAS CSCD 2005年第6期867-870,共4页
AIM: To polymerase P region (YMDD) mutations of hepatitis B virus gene (HBV DNA) in patients with chronic hepatitis B (CHB) untreated with antiviral medicines and to explore its correlation with pre-c-zone mutations, ... AIM: To polymerase P region (YMDD) mutations of hepatitis B virus gene (HBV DNA) in patients with chronic hepatitis B (CHB) untreated with antiviral medicines and to explore its correlation with pre-c-zone mutations, HBV genotypes and HBV DNA level, and to observe its curative effect.METHODS: A total of 104 cases (38 cases in group of familial aggregation and 66 cases in group of non-familial aggregation) were randomly chosen from 226 patients with CHB who did not receive the treatment of lamivudine (LAM)and any other antivirus drugs within the last one year.Their serum YMDD mutations were detected by microcosmic nucleic acid and cross-nucleic acid quantitative determination,HBV genotypes by PCR-microcosmic nucleic acid crossELISA, HBV DNA quantitative determination and fluorescence ration PCR analysis, hepatitis B virus markers (HBVM) by ELISA. LAM was taken by 10 patients with YMDD mutations and its curative effect was observed.RESULTS: Twenty-eight cases (26.9%) had YMDD mutations, of them 11 cases (28.9%) were in familial aggregation group (38 cases) and 17 cases (25.8%) in nonfamilial aggregation group (66 cases) with no significant difference between the two groups. Twenty-seven point one percent (16/59) cases were positive for HBeAg YMDD mutations, and 26.7% (12/45) cases were negative for HBeAg and positive for anti-HBe. There was also no significant difference between the two groups. Different YMDD incidence rate existed in different HBV genotypes.HBV DNA level did not have a positive correlation with the incidence of YMDD mutations. LAM was effective for all patients with mutations.CONCLUSION: Wild mutant strains in HBV and their incidence rate have no significant difference between familial aggregation and non-familial aggregation. It may have no significant relationship between YMDD mutations and pre-c-zone mutations. HBV DNA level may not have a positive correlation with YMDD mutations. LAM is clinically effective for CHB patients with YMDD mutations. 展开更多
关键词 Hepatitis B virus Chronic hepatitis GENOTYPES YMDD mutation LAMIVUDINE
下载PDF
Antiviral Activity of the Effective Monomers from Folium Isatidis Against Influenza Virus in Vivo 被引量:9
10
作者 Zhao LIU Zhan-qiu YANG Hong XIAO 《Virologica Sinica》 SCIE CAS CSCD 2010年第6期445-451,共7页
In order to evaluate the anti-influenza virus activity of the effective monomer from Folium Isatidis (FI) in vivo,we established mice model with viral pneumonia and divided them into 3 different dose groups,then obser... In order to evaluate the anti-influenza virus activity of the effective monomer from Folium Isatidis (FI) in vivo,we established mice model with viral pneumonia and divided them into 3 different dose groups,then observed their lung indexes,pulmonary pathological changes,pulmonary virus hemagglitination titers,living time and death rates.The results showed that the monomer could reduce the pulmonary index from 2.64 to 1.93,1.63 and 1.40 (P<0.01) and decrease the hemagglitination titer from 1.15 to 0.84,0.70 and 0.59 (P<0.01).In addition,different groups of FI could significantly lessen the mortality rate from 100% to 30%,25% and 15%,and prolong the living time from 5.1d to 6.5d,8.4d and 8.9d respectively(P<0.01).The high dose (75 mg/kg/d) has the similar effect with 100 mg/kg/d dose of virazole(P>0.05),and more effective than 200 mg/kg/d dose of antiviral liquor (P<0.05). 展开更多
关键词 Folium Isatidis MONOMERS Influenza virus Antiviral activity In vivo
下载PDF
Plasma Levels of Leukotriene B4 and Prostaglandin E2 Correlation with Endoscopic Changes after NSAID Gastropathies Pantoprazole Treatment in Patients with Cardiovascular Pathology
11
作者 Maher Mbarki Helen Sklyarova +2 位作者 Krystyna Aksentiychuk Ihor Tumak Eugene Sklyarov 《Journal of Pharmacy and Pharmacology》 2016年第8期432-436,共5页
The article describes the pantoprazole healing effect on the gastroduodenal mucosa in patients with NSAID gastropathy. Two groups of patients were compared, depending on the treatment they have got group, which was ta... The article describes the pantoprazole healing effect on the gastroduodenal mucosa in patients with NSAID gastropathy. Two groups of patients were compared, depending on the treatment they have got group, which was taking 75 mg of enteric aspirin per day and the group, where pantoprazole has been added to aspirin in the usual dose. Mucosa assessment was studied using fibrogastroduodenoscopy and Lanza score. Also, the relationship between aggression factors that cause NSAID gastropathy and mucosal protection agents has been studied. It was proved that the pantoprazole influence reduces the ulcerative-erosive lesions amount. Stomach erosive lesions percentage decreased from 58.18% to 42.42%, stomach ulcers from 14.55% to 6.06%, duodenum erosive lesions decreased from 34.55% to 24.24%, duodenum ulcers deceased from 9.09% to 3.03%. A positive correlation between LTB4 and Lanza scale was checked after pantoprazole treatment, indicating an impact on the LTB4 reduction in ulcers healing in patients with NSAID gastropathy. 展开更多
关键词 ASPIRIN NSAIDS PANTOPRAZOLE LTB4 PGE2.
下载PDF
In Vivo Anti-Inflammatory Assessment of Quillaja saponaria Mol. Extracts
12
作者 Mait6 Rodriguez-Diaz Olosmira Correa +2 位作者 Carlos Cartagen Bruce K. Cassels CarlaDelporte 《Journal of Life Sciences》 2013年第12期1243-1248,共6页
Aqueous extracts from the native Chilean Quillaja saponaria tree are used orally and topically to treat lung inflammatory problems and toothache. This study aimed to corroborate their presumed anti-inflammatory activi... Aqueous extracts from the native Chilean Quillaja saponaria tree are used orally and topically to treat lung inflammatory problems and toothache. This study aimed to corroborate their presumed anti-inflammatory activity, identify their active ingredients and validate their use. The topical anti-inflammatory activity of a commercial partially purified Quillaja saponin aqueous extract (Ultra Dry 100Q, UD), the crude acid hydrolysate (H-100Q) of this material, its two most abundant sapogenins QA (quillaic acid) and PA (phytolaccagenic acid), and two formulations containing QA were subjected to topical assays for the inhibition ofmurine ear inflammation elicited by AA (arachidonic acid) or TPA (phorbol ester). The dose-dependent anti-inflammatory activity of QA was confirmed in both AA (maximal effect 92.1%) and TPA (maximal effect 62.2%) assays, and PA showed significant anti-inflammatory activity against AA (46.5%). Two dermo pharmaceutical formulations containing 8% w/v QA as the active ingredient--a cream and a gel--also exhibited significant anti-inflammatory effects in the TPA (50.8%) and AA (39.5%) assays. 展开更多
关键词 Quillaja saponaria TRITERPENOIDS quillaic acid phytolaccagenic acid topical anti-inflammatory activity phorbol acetate arachidonic acid.
下载PDF
上一页 1 下一页 到第
使用帮助 返回顶部