Objective: To independently evaluate the effect of body mass index (BMI) on implantation, pregnancy, and incidence of spontaneous miscarriage using the donor oocyte recipient model. Design: Institutional Review Board-...Objective: To independently evaluate the effect of body mass index (BMI) on implantation, pregnancy, and incidence of spontaneous miscarriage using the donor oocyte recipient model. Design: Institutional Review Board- app- roved retrospective data analyses of donor oocyte cycles from 1999 to 2004. Setting: Private assisted reproductive technology (ART) center. Patient(s): Five hundred thirty- six first cycle recipients of donor oocytes. Intervention(s): Data were collected from the first cycle of each donor oocyte recipient included in the study. The body mass index (BMI) of each recipient was calculated using the formula weight (in kilograms)/height (in meters squared). Patients were divided into four groups based on BMI: underweight, normal, overweight, and obese. Pregnancy outcomes in each group were compared. Main Outcome Measure(s): Body mass index, implantation rate, pregnancy rate (PR), miscarriage rate. Result(s): There were no statistically significant differences in the implantation rates, ongoing PRs, or spontaneous abortion rates among patients in the four BMI groups. When further divided into those patients receiving blastocyst vs. day 3 transfers, there was still no effect of BMI on implantation rate, PR, or loss rate among the blastocyst or day 3 donor oocyte recipients. Conclusion(s): Body mass index has no adverse impact on implantation or reproductive outcome in donor oocyte recipients. Therefore, obesity does not appear to exert a negative effect on endometrial receptivity.展开更多
To define the recipient related determinants of outcome with donor eggs. Case control study. Community hospital based assisted reproductive technology (ART) program. One hundred thirty four embryo transfers (ETs) in w...To define the recipient related determinants of outcome with donor eggs. Case control study. Community hospital based assisted reproductive technology (ART) program. One hundred thirty four embryo transfers (ETs) in which two recipients were matched to one donor. Controlled ovarian hyperstimulation (COH) and ovum retrieval in donors; IVF and ET to recipients. Recipients age, body mass index (BMI), medical conditions, endometriosis, gravidity, uterine pathology, endometrial thickness, egg number, total motile sperm count, intracytoplasmic sperm injection (ICSI), zygote number, fertilization rate, embryos per ET, embryos frozen, embryo quality, difficulty with transfer, and ongoing pregnancies per ET. Forty one recipient pairs had discordant outcomes. Pregnant patients had a lower frequency (9.7% vs. 31.7% , P=.04) and lesser severity of uterine pathology. Endometrium <8 mm was found solely in failed cycles. Pregnant women had fewer moderate or difficult ETs (9.7% vs. 31.7% , P=.04) and more good embryos (1.8 vs. 1.3, P=.03) than the nonpregnant group. Analysis of recipient pairs with discordant outcomes identifies the recipient related predictors of success by keeping oocyte quality and the laboratory component constant. Uterine pathology, thin endometrium, transfer difficulty, and number of high grade embryos are the principal recipient related determinants of outcome with donor eggs.展开更多
文摘Objective: To independently evaluate the effect of body mass index (BMI) on implantation, pregnancy, and incidence of spontaneous miscarriage using the donor oocyte recipient model. Design: Institutional Review Board- app- roved retrospective data analyses of donor oocyte cycles from 1999 to 2004. Setting: Private assisted reproductive technology (ART) center. Patient(s): Five hundred thirty- six first cycle recipients of donor oocytes. Intervention(s): Data were collected from the first cycle of each donor oocyte recipient included in the study. The body mass index (BMI) of each recipient was calculated using the formula weight (in kilograms)/height (in meters squared). Patients were divided into four groups based on BMI: underweight, normal, overweight, and obese. Pregnancy outcomes in each group were compared. Main Outcome Measure(s): Body mass index, implantation rate, pregnancy rate (PR), miscarriage rate. Result(s): There were no statistically significant differences in the implantation rates, ongoing PRs, or spontaneous abortion rates among patients in the four BMI groups. When further divided into those patients receiving blastocyst vs. day 3 transfers, there was still no effect of BMI on implantation rate, PR, or loss rate among the blastocyst or day 3 donor oocyte recipients. Conclusion(s): Body mass index has no adverse impact on implantation or reproductive outcome in donor oocyte recipients. Therefore, obesity does not appear to exert a negative effect on endometrial receptivity.
文摘To define the recipient related determinants of outcome with donor eggs. Case control study. Community hospital based assisted reproductive technology (ART) program. One hundred thirty four embryo transfers (ETs) in which two recipients were matched to one donor. Controlled ovarian hyperstimulation (COH) and ovum retrieval in donors; IVF and ET to recipients. Recipients age, body mass index (BMI), medical conditions, endometriosis, gravidity, uterine pathology, endometrial thickness, egg number, total motile sperm count, intracytoplasmic sperm injection (ICSI), zygote number, fertilization rate, embryos per ET, embryos frozen, embryo quality, difficulty with transfer, and ongoing pregnancies per ET. Forty one recipient pairs had discordant outcomes. Pregnant patients had a lower frequency (9.7% vs. 31.7% , P=.04) and lesser severity of uterine pathology. Endometrium <8 mm was found solely in failed cycles. Pregnant women had fewer moderate or difficult ETs (9.7% vs. 31.7% , P=.04) and more good embryos (1.8 vs. 1.3, P=.03) than the nonpregnant group. Analysis of recipient pairs with discordant outcomes identifies the recipient related predictors of success by keeping oocyte quality and the laboratory component constant. Uterine pathology, thin endometrium, transfer difficulty, and number of high grade embryos are the principal recipient related determinants of outcome with donor eggs.
