Recent studies have uncovered two signaling pathways that activate the host innate immunity against viral infection. One of the pathways utilizes members of the Toll-like receptor （TLR） family to detect viruses that...Recent studies have uncovered two signaling pathways that activate the host innate immunity against viral infection. One of the pathways utilizes members of the Toll-like receptor （TLR） family to detect viruses that enter the endosome through endocytosis. The TLR pathway induces interferon production through several signaling proteins that ultimately lead to the activation of the transcription factors NF-kB, IRF3 and IRFT. The other antiviral pathway uses the RNA helicase RIG-Ⅰ as the receptor for intracellular viral double-stranded RNA. RIG-Ⅰ activates NF-kB and IRFs through the recently identified adaptor protein MAVS, a CARD domain containing protein that resides in the mitochondrial membrane. MAVS is essential for antiviral innate immunity, but it also serves as a target of Hepatitis C virus （HCV）, which employs a viral protease to cleave MAVS off the mitochondria, thereby allowing HCV to escape the host immune system.展开更多
To solve the problem of time-awarc test case prioritization,a hybrid algorithm composed of integer linear programming and the genetic algorithm(ILP-GA)is proposed.First,the test case suite which cm maximize the number...To solve the problem of time-awarc test case prioritization,a hybrid algorithm composed of integer linear programming and the genetic algorithm(ILP-GA)is proposed.First,the test case suite which cm maximize the number of covered program entities a d satisfy time constraints is selected by integer linea progamming.Secondly,the individual is encoded according to the cover matrices of entities,and the coverage rate of program entities is used as the fitness function and the genetic algorithm is used to prioritize the selected test cases.Five typical open source projects are selected as benchmark programs.Branch and method are selected as program entities,and time constraint percentages a e 25%and 75%.The experimental results show that the ILP-GA convergence has faster speed and better stability than ILP-additional and IP-total in most cases,which contributes to the detection of software defects as early as possible and reduces the software testing costs.展开更多
Hirschsprung's disease is a congenital disorder that occurs in 1:5000 live births. It is characterised by an absence of enteric neurons along a variable region of the gastrointestinal tract. Hirschsprung's dis...Hirschsprung's disease is a congenital disorder that occurs in 1:5000 live births. It is characterised by an absence of enteric neurons along a variable region of the gastrointestinal tract. Hirschsprung's disease is classified as a multigenic disorder, because the same phenotype is associated with mutations in multiple distinct genes. Furthermore, the genetics of Hirschsprung's disease are highly complex and not strictly Mendelian. The phenotypic variability and incomplete penetrance observed in Hirschsprung' s disease also suggests the involvement of modifier genes. Here, we summarise the current knowledge of the genetics underlying Hirschsprung's disease based on human and animal studies, focusing on the principal causative genes, their interactions, and the role of modif ier genes.展开更多
In this paper, based on the utility preferential attachment, we propose a new unified model to generate different network topologies such as scale-free, small-world and random networks. Moreover, a new network structu...In this paper, based on the utility preferential attachment, we propose a new unified model to generate different network topologies such as scale-free, small-world and random networks. Moreover, a new network structure named super scale network is found, which has monopoly characteristic in our simulation experiments. Finally, the characteristics of this new network are given.展开更多
Electronic skins and flexible pressure sensors are important devices for advanced healthcare and intelligent robotics.Sensitivity is a key parameter of flexible pressure sensors.Whereas introducing surface microstruct...Electronic skins and flexible pressure sensors are important devices for advanced healthcare and intelligent robotics.Sensitivity is a key parameter of flexible pressure sensors.Whereas introducing surface microstructures in a capacitive-type sensor can significantly improve its sensitivity,the signal becomes nonlinear and the pressure response range gets much narrower,significantly limiting the applications of flexible pressure sensors.Here,we designed a pressure sensor that utilizes a nanoscale iontronic interface of an ionic gel layer and a micropillared electrode,for highly linear capacitance-to-pressure response and high sensitivity over a wide pressure range.The micropillars undergo three stages of deformation upon loading:initial contact(0-6 k Pa)and structure buckling(6-12 k Pa)that exhibit a low and nonlinear response,as well as a post-buckling stage that has a high signal linearity with high sensitivity(33.16 k Pa-1)over a broad pressure range of 12-176 k Pa.The high linearity lies in the subtle balance between the structure compression and mechanical matching of the two materials at the gel-electrode interface.Our sensor has been applied in pulse detection,plantar pressure mapping,and grasp task of an artificial limb.This work provides a physical insight in achieving linear response through the design of appropriate microstructures and selection of materials with suitable modulus in flexible pressure sensors,which are potentially useful in intelligent robots and health monitoring.展开更多
文摘Recent studies have uncovered two signaling pathways that activate the host innate immunity against viral infection. One of the pathways utilizes members of the Toll-like receptor （TLR） family to detect viruses that enter the endosome through endocytosis. The TLR pathway induces interferon production through several signaling proteins that ultimately lead to the activation of the transcription factors NF-kB, IRF3 and IRFT. The other antiviral pathway uses the RNA helicase RIG-Ⅰ as the receptor for intracellular viral double-stranded RNA. RIG-Ⅰ activates NF-kB and IRFs through the recently identified adaptor protein MAVS, a CARD domain containing protein that resides in the mitochondrial membrane. MAVS is essential for antiviral innate immunity, but it also serves as a target of Hepatitis C virus （HCV）, which employs a viral protease to cleave MAVS off the mitochondria, thereby allowing HCV to escape the host immune system.
基金The Natural Science Foundation of Education Ministry of Shaanxi Province(No.15JK1672)the Industrial Research Project of Shaanxi Province(No.2017GY-092)Special Fund for Key Discipline Construction of General Institutions of Higher Education in Shaanxi Province
文摘To solve the problem of time-awarc test case prioritization,a hybrid algorithm composed of integer linear programming and the genetic algorithm(ILP-GA)is proposed.First,the test case suite which cm maximize the number of covered program entities a d satisfy time constraints is selected by integer linea progamming.Secondly,the individual is encoded according to the cover matrices of entities,and the coverage rate of program entities is used as the fitness function and the genetic algorithm is used to prioritize the selected test cases.Five typical open source projects are selected as benchmark programs.Branch and method are selected as program entities,and time constraint percentages a e 25%and 75%.The experimental results show that the ILP-GA convergence has faster speed and better stability than ILP-additional and IP-total in most cases,which contributes to the detection of software defects as early as possible and reduces the software testing costs.
基金Supported by The National Health and Medical Research Council of Australia to Anderson RB: Project grant, No. 509219a CDA Fellowship, No. 454773
文摘Hirschsprung's disease is a congenital disorder that occurs in 1:5000 live births. It is characterised by an absence of enteric neurons along a variable region of the gastrointestinal tract. Hirschsprung's disease is classified as a multigenic disorder, because the same phenotype is associated with mutations in multiple distinct genes. Furthermore, the genetics of Hirschsprung's disease are highly complex and not strictly Mendelian. The phenotypic variability and incomplete penetrance observed in Hirschsprung' s disease also suggests the involvement of modifier genes. Here, we summarise the current knowledge of the genetics underlying Hirschsprung's disease based on human and animal studies, focusing on the principal causative genes, their interactions, and the role of modif ier genes.
基金The project partly supported by the State 0utstanding Youth Foundation under Grant No. 70225005, National Natural Science Foundation of China under Grant Nos. 70501005, 70501004, and 70471088, the Natural Science Foundation of Beijing under Grant No. 9042006, the Special Program for Preliminary Research of Momentous Fundamental Research under Grant No. 2005CCA03900, the Innovation Foundation of Science and Technology for Excellent Doctorial Candidate of Beijing Jiaotong University under Grant No. 48006
文摘In this paper, based on the utility preferential attachment, we propose a new unified model to generate different network topologies such as scale-free, small-world and random networks. Moreover, a new network structure named super scale network is found, which has monopoly characteristic in our simulation experiments. Finally, the characteristics of this new network are given.
基金supported by the Science Technology and Innovation Committee of Shenzhen Municipality(JCYJ20170817111714314)the National Natural Science Foundation of China(52073138 and 51771089)+2 种基金the Guangdong Innovative and Entrepreneurial Research Team Program(2016ZT06G587)the Shenzhen Sci-Tech Fund(KYTDPT20181011104007)the Tencent Robotics X Lab Rhino-Bird Focused Research Program(JR201984)。
文摘Electronic skins and flexible pressure sensors are important devices for advanced healthcare and intelligent robotics.Sensitivity is a key parameter of flexible pressure sensors.Whereas introducing surface microstructures in a capacitive-type sensor can significantly improve its sensitivity,the signal becomes nonlinear and the pressure response range gets much narrower,significantly limiting the applications of flexible pressure sensors.Here,we designed a pressure sensor that utilizes a nanoscale iontronic interface of an ionic gel layer and a micropillared electrode,for highly linear capacitance-to-pressure response and high sensitivity over a wide pressure range.The micropillars undergo three stages of deformation upon loading:initial contact(0-6 k Pa)and structure buckling(6-12 k Pa)that exhibit a low and nonlinear response,as well as a post-buckling stage that has a high signal linearity with high sensitivity(33.16 k Pa-1)over a broad pressure range of 12-176 k Pa.The high linearity lies in the subtle balance between the structure compression and mechanical matching of the two materials at the gel-electrode interface.Our sensor has been applied in pulse detection,plantar pressure mapping,and grasp task of an artificial limb.This work provides a physical insight in achieving linear response through the design of appropriate microstructures and selection of materials with suitable modulus in flexible pressure sensors,which are potentially useful in intelligent robots and health monitoring.
