Thermosensitive drug delivery systems （DDSs） face major challenges, such as remote and repeatable control of in vivo temperature, although these can increase the therapeutic efficacy of drugs. To address this issue,...Thermosensitive drug delivery systems （DDSs） face major challenges, such as remote and repeatable control of in vivo temperature, although these can increase the therapeutic efficacy of drugs. To address this issue, we coated near- infrared （NIR） photothermal Cu175S nanocrystals with pH/thermos-sensitive polymer by in situ polymerization. The doxorubicine （DOX） loading content was up to 40 wt.%, with less than 8.2 wt.% of DOX being leaked under normal physiological conditions （pH = 7.4, 37 ~C） for almost 48 h in the absence of NIR light. These nanocapsules demonstrate excellent photothermal stability by continuous long- term NIR irradiation. Based on the stable and high photothermal efficiency （55.8%）, pre-loaded drugs were released as desired using 808-nm light as a trigger. Both in vitro and in vivo antitumor therapy results demonstrated that this smart nanoplatform is an effective agent for synergistic hyperthermia-based chemotherapy of cancer, demonstratin~ remote and noninvasive control.展开更多
文摘Thermosensitive drug delivery systems （DDSs） face major challenges, such as remote and repeatable control of in vivo temperature, although these can increase the therapeutic efficacy of drugs. To address this issue, we coated near- infrared （NIR） photothermal Cu175S nanocrystals with pH/thermos-sensitive polymer by in situ polymerization. The doxorubicine （DOX） loading content was up to 40 wt.%, with less than 8.2 wt.% of DOX being leaked under normal physiological conditions （pH = 7.4, 37 ~C） for almost 48 h in the absence of NIR light. These nanocapsules demonstrate excellent photothermal stability by continuous long- term NIR irradiation. Based on the stable and high photothermal efficiency （55.8%）, pre-loaded drugs were released as desired using 808-nm light as a trigger. Both in vitro and in vivo antitumor therapy results demonstrated that this smart nanoplatform is an effective agent for synergistic hyperthermia-based chemotherapy of cancer, demonstratin~ remote and noninvasive control.
