目的观察老年肺结核患者细胞及体液免疫状况,探讨免疫干预治疗对患者免疫状态的影响。方法选取80例老年肺结核患者(A组)以及80名健康老年人(B组),比较两组患者细胞及体液免疫功能指标。80例老年肺结核患者随机分为治疗组(n=40)和对照组(...目的观察老年肺结核患者细胞及体液免疫状况,探讨免疫干预治疗对患者免疫状态的影响。方法选取80例老年肺结核患者(A组)以及80名健康老年人(B组),比较两组患者细胞及体液免疫功能指标。80例老年肺结核患者随机分为治疗组(n=40)和对照组(n=40),分别予以抗结核治疗联合免疫干预治疗和单纯抗结核治疗,比较两种方法治疗10 w后细胞及体液免疫功能指标。结果老年肺结核患者与老年健康者相比,外周血CD3+、CD4+T淋巴细胞百分比以及CD4+/CD8+比值降低〔(59.86±10.04)%vs(67.82±4.68)%,(30.64±10.93)%vs(40.87±4.78)%,1.06±0.13 vs 1.83±0.05〕,CD8+T淋巴细胞百分比较高〔(29.01±11.57)%vs(23.72±5.88)%〕(P<0.05);体液免疫功能无统计学差异(P>0.05)。80例老年肺结核患者中治疗组免疫干预治疗10 w后外周血CD3+、CD4+T淋巴细胞百分比以及CD4+/CD8+比值较对照组明显升高〔(65.73±7.21)%vs(58.93±10.20)%,(40.94±8.83)%vs(31.17±9.96)%,(1.66±0.13)vs(1.09±0.07)〕,CD8+T淋巴细胞百分比降低〔(23.01±7.19)vs(30.21±10.87)%〕(P<0.05)。结论老年肺结核患者细胞免疫功能低下,免疫干预治疗能够提高患者细胞免疫功能。展开更多
In the treatment of AIDS the highly-active anti-retroviral therapy(HAART) is potential and effective,but after one year of practice,many disadvantages appeared:After withdrawal of medication(short or long term) the pl...In the treatment of AIDS the highly-active anti-retroviral therapy(HAART) is potential and effective,but after one year of practice,many disadvantages appeared:After withdrawal of medication(short or long term) the plasma virus level rapidly rebound to that of before treatment which existed originally in the lymph nodes;there are different types of HIV susceptible cells,some of them could not be reached or being insensitive by anti-retroviral therapy(ART);ART agent’s target is designed against different life cycle.they can Iower the plasma VL IeveI to undetectable Ievel.but they cannot revive the destroyed immune system to normal immune function.as soon as withdrawaI occurred.the body still couldn’t yield immune response to HIV;the original combination using of ART is to clear the virus and prevent the drug tolerance,but under the pressure of highdosage of ART,the appearance of tolerance is inevitable.After HAART treatment.4 kinds of treatment occurred:40% patients after effective inhibit plasma VL.immune reconstitution appeared;40%patients VL does not reduce.but CD4 gradually increase;5% patients VL began to lower,but CD4 without recovery:Completely ineffective,without any improvement both in VL and CD4 count.The tolerance of ART and immune impairment are 2 important factors.the latter is more important.Lymphocyte is activated against HIV replication.including HIV specific cytotoxic action.cytokine secretion,etc.But the large amount of infected cells,the specific viral gene and phenotype variation would cause the activated lymphocyte unable to clear-up the HIV and HIV-infected cells,the specific cytotoxic lymphocyte(CTL)and CD4 T helper inactivated.Three kinds of medicine were being used:Immune cell activator(IL-2,IFN-γ),immunosuppressor(cyclosporin A)and virus replication inhibitor(IL-10,MIP-l α)to activate macrophage and promote immune response.TCM immuno-modulatory effect in treating AIDS:Immune-based intervention is regression of natural medicine, it re-evaluates the effect of organic immune system in treating HlV/AIDS.which coincides with holistic approach and syndrome differentiation theory in TCM.Astragalus membanaceus contains many jmmuno-modulatory active substances,which could reverse the immunosuppressor induced immunosuppression,promote the production of cytotoxic T lymphocytes.The polysaccharide in Lycium barbarum and Ligusticum lucidum could reproduce the splenic activating cells,displays mitogenoid action.And the polysaccharide of Angelica sinensis,Embellatus polyporus could stimulate lymphocyte reproduction.Ginsenoside and polysaccharide could obviously induce IL-2 and its gene expression.Some compound recipes(802、806、809) could increase plaque forming cells(PFC),serum rosette formling cells(SRFC) and delayed-type hypersensitivity(DTH),promote IL-1 and IL-2 production,and increase the CD4 cell count and reverse the CD4/CD8 ratio.Zhongyan-2 could raise CD4 celI count for 50 cells/mm 3,IL-2 and IFN have increasing tendency,Neopterin and β 2 microglobulin also showed elevation.展开更多
文摘目的观察老年肺结核患者细胞及体液免疫状况,探讨免疫干预治疗对患者免疫状态的影响。方法选取80例老年肺结核患者(A组)以及80名健康老年人(B组),比较两组患者细胞及体液免疫功能指标。80例老年肺结核患者随机分为治疗组(n=40)和对照组(n=40),分别予以抗结核治疗联合免疫干预治疗和单纯抗结核治疗,比较两种方法治疗10 w后细胞及体液免疫功能指标。结果老年肺结核患者与老年健康者相比,外周血CD3+、CD4+T淋巴细胞百分比以及CD4+/CD8+比值降低〔(59.86±10.04)%vs(67.82±4.68)%,(30.64±10.93)%vs(40.87±4.78)%,1.06±0.13 vs 1.83±0.05〕,CD8+T淋巴细胞百分比较高〔(29.01±11.57)%vs(23.72±5.88)%〕(P<0.05);体液免疫功能无统计学差异(P>0.05)。80例老年肺结核患者中治疗组免疫干预治疗10 w后外周血CD3+、CD4+T淋巴细胞百分比以及CD4+/CD8+比值较对照组明显升高〔(65.73±7.21)%vs(58.93±10.20)%,(40.94±8.83)%vs(31.17±9.96)%,(1.66±0.13)vs(1.09±0.07)〕,CD8+T淋巴细胞百分比降低〔(23.01±7.19)vs(30.21±10.87)%〕(P<0.05)。结论老年肺结核患者细胞免疫功能低下,免疫干预治疗能够提高患者细胞免疫功能。
文摘In the treatment of AIDS the highly-active anti-retroviral therapy(HAART) is potential and effective,but after one year of practice,many disadvantages appeared:After withdrawal of medication(short or long term) the plasma virus level rapidly rebound to that of before treatment which existed originally in the lymph nodes;there are different types of HIV susceptible cells,some of them could not be reached or being insensitive by anti-retroviral therapy(ART);ART agent’s target is designed against different life cycle.they can Iower the plasma VL IeveI to undetectable Ievel.but they cannot revive the destroyed immune system to normal immune function.as soon as withdrawaI occurred.the body still couldn’t yield immune response to HIV;the original combination using of ART is to clear the virus and prevent the drug tolerance,but under the pressure of highdosage of ART,the appearance of tolerance is inevitable.After HAART treatment.4 kinds of treatment occurred:40% patients after effective inhibit plasma VL.immune reconstitution appeared;40%patients VL does not reduce.but CD4 gradually increase;5% patients VL began to lower,but CD4 without recovery:Completely ineffective,without any improvement both in VL and CD4 count.The tolerance of ART and immune impairment are 2 important factors.the latter is more important.Lymphocyte is activated against HIV replication.including HIV specific cytotoxic action.cytokine secretion,etc.But the large amount of infected cells,the specific viral gene and phenotype variation would cause the activated lymphocyte unable to clear-up the HIV and HIV-infected cells,the specific cytotoxic lymphocyte(CTL)and CD4 T helper inactivated.Three kinds of medicine were being used:Immune cell activator(IL-2,IFN-γ),immunosuppressor(cyclosporin A)and virus replication inhibitor(IL-10,MIP-l α)to activate macrophage and promote immune response.TCM immuno-modulatory effect in treating AIDS:Immune-based intervention is regression of natural medicine, it re-evaluates the effect of organic immune system in treating HlV/AIDS.which coincides with holistic approach and syndrome differentiation theory in TCM.Astragalus membanaceus contains many jmmuno-modulatory active substances,which could reverse the immunosuppressor induced immunosuppression,promote the production of cytotoxic T lymphocytes.The polysaccharide in Lycium barbarum and Ligusticum lucidum could reproduce the splenic activating cells,displays mitogenoid action.And the polysaccharide of Angelica sinensis,Embellatus polyporus could stimulate lymphocyte reproduction.Ginsenoside and polysaccharide could obviously induce IL-2 and its gene expression.Some compound recipes(802、806、809) could increase plaque forming cells(PFC),serum rosette formling cells(SRFC) and delayed-type hypersensitivity(DTH),promote IL-1 and IL-2 production,and increase the CD4 cell count and reverse the CD4/CD8 ratio.Zhongyan-2 could raise CD4 celI count for 50 cells/mm 3,IL-2 and IFN have increasing tendency,Neopterin and β 2 microglobulin also showed elevation.
