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软肝冲剂对大鼠肝星状细胞增殖及分泌TGFβ_1影响的血清药理学研究 被引量:5
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作者 李平 朱清静 +2 位作者 张建军 向楠 邓欣 《中国中医药科技》 CAS 2001年第5期292-293,共2页
关键词 软肝冲剂 肝星状细胞增殖 分泌tgfβ1 血清药理学
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EFFECTS OF TGF β1 AUTOCRINE BLOCKAGE ONOSTEOSARCOMA CELLS
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作者 YongLiu Qi-xinZheng Jing-yuanDu Shu-huaYang Zeng-wuShao Bao-junXiao 《Chinese Medical Sciences Journal》 CAS CSCD 2004年第2期155-156,共2页
Objective To evaluate the effects of transforming growth factor β1 (TGF β1) autocrine blockage on proliferation activity and drug sensitivity of osteosarcoma. Methods Northern blot, MTT determination, and 3H thymidi... Objective To evaluate the effects of transforming growth factor β1 (TGF β1) autocrine blockage on proliferation activity and drug sensitivity of osteosarcoma. Methods Northern blot, MTT determination, and 3H thymidine incorporation were used to investigate the effects of antisense TGF β1 gene on osteosarcoma. Results The proliferation of osteosarcoma cells transfected by antisense TGF β1 gene was suppressed markedly, and adriamycin sensitivity was significantly increased. Conclusion Blockage of osteosarcoma cells TGF β1 autocrine loop inhibits cell proliferation and enhances chemother-apy sensitivity. 展开更多
关键词 transfoming growth factor β1 autocrine loop OSTEOSARCOMA
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