The authors investigated the relationship between obstructive sleep apnea/hypopnea (OSAH) and cognition in 36 older adults, 18 APOE ∈4 carriers, and 18 non-carriers. Greater numbers of respiratory events negatively i...The authors investigated the relationship between obstructive sleep apnea/hypopnea (OSAH) and cognition in 36 older adults, 18 APOE ∈4 carriers, and 18 non-carriers. Greater numbers of respiratory events negatively impacted memory function in 4 carriers only. This is the first study to provide preliminary evidence for a negative interaction of APOE ∈4 and OSAH on memory in older adults, which may have important implications for treating cognitive decline and delaying dementia onset.展开更多
文摘The authors investigated the relationship between obstructive sleep apnea/hypopnea (OSAH) and cognition in 36 older adults, 18 APOE ∈4 carriers, and 18 non-carriers. Greater numbers of respiratory events negatively impacted memory function in 4 carriers only. This is the first study to provide preliminary evidence for a negative interaction of APOE ∈4 and OSAH on memory in older adults, which may have important implications for treating cognitive decline and delaying dementia onset.
