目的:评价新药甲磺酸加替沙星氯化钠注射液治疗下呼吸道细菌感染性疾病的疗效和安全性。方法:以加替沙星注射液为对照药,用随机双盲对照实验研究。结果:甲磺酸加替沙星氯化钠注射液组治疗下呼吸道感染的临床痊愈率与总有效率分别为72．...目的:评价新药甲磺酸加替沙星氯化钠注射液治疗下呼吸道细菌感染性疾病的疗效和安全性。方法:以加替沙星注射液为对照药,用随机双盲对照实验研究。结果:甲磺酸加替沙星氯化钠注射液组治疗下呼吸道感染的临床痊愈率与总有效率分别为72．5％及90％,与对照组分别为63．2％及81．6％相比,有统计学差异。不良反应发生率为7．5％ vs 10．5％,差异无统计学意义。结论:甲磺酸加替沙星氯化钠注射液治疗下呼吸道感染临床疗效较好,不良反应发生率较低。展开更多
AIM:To identify the main impurity of gatifloxacin.METHOD:P-demethylgatifloxacin was synthesized in four steps from ethyl 2-(3-methoxy-2,4,5-trifluorobenzoyl)-3-(cyclopropylamino) acrylate through cyclization,chelation...AIM:To identify the main impurity of gatifloxacin.METHOD:P-demethylgatifloxacin was synthesized in four steps from ethyl 2-(3-methoxy-2,4,5-trifluorobenzoyl)-3-(cyclopropylamino) acrylate through cyclization,chelation,N-piperazination and hydrolysis,and identified by LC/MS,UV, 1 HNMR , 13 CNMR ,MS.RESULT:the main impurity of gatifloxacin was P-demethylgatifloxacin.展开更多
文摘目的:评价新药甲磺酸加替沙星氯化钠注射液治疗下呼吸道细菌感染性疾病的疗效和安全性。方法:以加替沙星注射液为对照药,用随机双盲对照实验研究。结果:甲磺酸加替沙星氯化钠注射液组治疗下呼吸道感染的临床痊愈率与总有效率分别为72．5％及90％,与对照组分别为63．2％及81．6％相比,有统计学差异。不良反应发生率为7．5％ vs 10．5％,差异无统计学意义。结论:甲磺酸加替沙星氯化钠注射液治疗下呼吸道感染临床疗效较好,不良反应发生率较低。
文摘AIM:To identify the main impurity of gatifloxacin.METHOD:P-demethylgatifloxacin was synthesized in four steps from ethyl 2-(3-methoxy-2,4,5-trifluorobenzoyl)-3-(cyclopropylamino) acrylate through cyclization,chelation,N-piperazination and hydrolysis,and identified by LC/MS,UV, 1 HNMR , 13 CNMR ,MS.RESULT:the main impurity of gatifloxacin was P-demethylgatifloxacin.
