目的探讨CT血管造影(CTA)升主动脉长度与最大直径对主动脉夹层预测价值。方法回顾性分析2017年4月-2021年4月期间南京医科大学第一附属医院放射科进行检查的急性A型主动脉夹层(acute type A aortic dissection,ATAAD)66例患者的影像学...目的探讨CT血管造影(CTA)升主动脉长度与最大直径对主动脉夹层预测价值。方法回顾性分析2017年4月-2021年4月期间南京医科大学第一附属医院放射科进行检查的急性A型主动脉夹层(acute type A aortic dissection,ATAAD)66例患者的影像学资料。患者均进行CTA,将ATAAD发病的13例设为试验组;升主动脉最大直径≥40mm的14例患者设为对照一组;升主动脉最大直径<40mm的39例患者设为对照二组。对三组的升主动脉长度、最大直径进行对比同时进行ROC曲线的评估,通过对数据的分析升主动脉长度和最大直径对主动脉夹层的相关性和对疾病预测效果。结果分析三组患者的升主动脉最大直径数据发现,对照二组患者的数据明显小于对照一组和试验组,数据存在明显的差异>有统计学意义(P<0.05)。对三组患者的升主动脉长度数据进行对比分析,对照二组<对照一组<试验组,对照一组、对照二组以及试验组两两之间均存在明显的差异,均有统计学意义(P<0.05)。计算ROC曲线下面积发现,升主动脉长度ROC曲线面积为0.887,升主动脉最大直径ROC曲线面积为0.821,选取55mm点预测主动脉夹层阳性率发现用升主动脉长度阳性率为75.8%,用升主动脉最大直径阳性率为24.6%,从数据上可知晓通过升主动脉长度能更提高ATAAD阳性预测率。结论从本次研究的数据分析可知,升主动脉长度和最大直径均对主动脉夹层有一定的预测可行性,相关之间存在一定的关联,且升主动脉长度预测主动脉夹层疾病的阳性率更高、更准确,能一定程度上帮助临床医师判断患者的疾病。展开更多
A consistent association has been observed between leukocyte telomere length(LTL)and atherosclerosis,but the mechanisms underlying these associations are still not well understood.Premature biology aging was evident i...A consistent association has been observed between leukocyte telomere length(LTL)and atherosclerosis,but the mechanisms underlying these associations are still not well understood.Premature biology aging was evident in atherosclerotic plaques,characterized by reduced cell proliferation,irreversible growth arrest and apoptosis,and telomere attrition.As atherosclerosis is a state of chronic low-grade inflammation and increased oxidative stress,shortened LTL in patients with atherosclerosis might stem from the two sources,one is an accelerated rate in hematopoietic stem cells(HSCs)replication to replace leukocytes consumed in the inflammatory process,and another is the increase in the loss of telomere repeats per replication.Thus,diminished HSC reserves at birth and age-dependent telomere attrition afterward are mirrored in shortened LTL during the adulthood.In addition,the inter-individual variation of LTL in the general population can be partly explained by genetic factors regulating telomere maintenance and the rate of HSCs replication.Atherosclerosis is an aging-related disease,and practically all humans develop atherosclerosis if they live long enough.Here we overview the potential roles of LTL dynamics in the imbalance between injurious oxidative stress/inflammation and endothelial repair during the pathogenesis of age-related atherosclerosis,and discuss the possibility that preventing accelerated cellular senescence is a potential target in prevention of atherosclerosis.展开更多
文摘目的探讨CT血管造影(CTA)升主动脉长度与最大直径对主动脉夹层预测价值。方法回顾性分析2017年4月-2021年4月期间南京医科大学第一附属医院放射科进行检查的急性A型主动脉夹层(acute type A aortic dissection,ATAAD)66例患者的影像学资料。患者均进行CTA,将ATAAD发病的13例设为试验组;升主动脉最大直径≥40mm的14例患者设为对照一组;升主动脉最大直径<40mm的39例患者设为对照二组。对三组的升主动脉长度、最大直径进行对比同时进行ROC曲线的评估,通过对数据的分析升主动脉长度和最大直径对主动脉夹层的相关性和对疾病预测效果。结果分析三组患者的升主动脉最大直径数据发现,对照二组患者的数据明显小于对照一组和试验组,数据存在明显的差异>有统计学意义(P<0.05)。对三组患者的升主动脉长度数据进行对比分析,对照二组<对照一组<试验组,对照一组、对照二组以及试验组两两之间均存在明显的差异,均有统计学意义(P<0.05)。计算ROC曲线下面积发现,升主动脉长度ROC曲线面积为0.887,升主动脉最大直径ROC曲线面积为0.821,选取55mm点预测主动脉夹层阳性率发现用升主动脉长度阳性率为75.8%,用升主动脉最大直径阳性率为24.6%,从数据上可知晓通过升主动脉长度能更提高ATAAD阳性预测率。结论从本次研究的数据分析可知,升主动脉长度和最大直径均对主动脉夹层有一定的预测可行性,相关之间存在一定的关联,且升主动脉长度预测主动脉夹层疾病的阳性率更高、更准确,能一定程度上帮助临床医师判断患者的疾病。
文摘A consistent association has been observed between leukocyte telomere length(LTL)and atherosclerosis,but the mechanisms underlying these associations are still not well understood.Premature biology aging was evident in atherosclerotic plaques,characterized by reduced cell proliferation,irreversible growth arrest and apoptosis,and telomere attrition.As atherosclerosis is a state of chronic low-grade inflammation and increased oxidative stress,shortened LTL in patients with atherosclerosis might stem from the two sources,one is an accelerated rate in hematopoietic stem cells(HSCs)replication to replace leukocytes consumed in the inflammatory process,and another is the increase in the loss of telomere repeats per replication.Thus,diminished HSC reserves at birth and age-dependent telomere attrition afterward are mirrored in shortened LTL during the adulthood.In addition,the inter-individual variation of LTL in the general population can be partly explained by genetic factors regulating telomere maintenance and the rate of HSCs replication.Atherosclerosis is an aging-related disease,and practically all humans develop atherosclerosis if they live long enough.Here we overview the potential roles of LTL dynamics in the imbalance between injurious oxidative stress/inflammation and endothelial repair during the pathogenesis of age-related atherosclerosis,and discuss the possibility that preventing accelerated cellular senescence is a potential target in prevention of atherosclerosis.
