Objective To investigate the expression profiles and their clinical significance of TRAIL receptors (TRAILR) in human hepatocellular carcinoma (HCC). Methods The expression profiles of TRAILR were determined in 60 s...Objective To investigate the expression profiles and their clinical significance of TRAIL receptors (TRAILR) in human hepatocellular carcinoma (HCC). Methods The expression profiles of TRAILR were determined in 60 samples from hepatocellular carcinoma, 20 from normal liver tissue and two HCC cell lines HepG2, SMMC-7721 by in situ hybridization. Results Both DR4 and DR5 were present in all HCC tissues as well as normal hepatic tissues. In contrast, 54 HCC tissues did not express DcR1 and 25 did not express DcR2. But both DcR were detectable in all of the normal liver tissues. The expression patterns of DR and DcR in HCC samples (higher DR expression level and lower DcR expression level) were quite different from those in normal tissue. DR5, DR4, and DcR2 expressed in both cell lines, while no DcR1 expression was detected. The expression level of DR was correlated with HCC differentiation and stage. The weaker expression was more commonly found in HCC with poor differentiation and late stage, while the stronger expression was more common in HCC with middle to high-differentiation and early stage. No relationship was found between DR and gender, age, negative or positive HBsAg, tumor size, grade or metastasis. Multidrug resistance cell lines expressed lower level DR. Conclusion TRAILR expression was prevalent and discrepancy of receptor types was exited in HCC. Loss of DcR1 may contribute for TRAIL therapy for HCC. Key words TRAILR - apoptosis - hepatocellular carcinoma Supported by the Major Fundation of Ministry of Health, NO. 2001–2003展开更多
The mid-southern section of the Hengduan Mountains is a typical region of mountainous landscape in western China and is the core region of "Shangri-La", a world-famous ecotourism destination. The landscape c...The mid-southern section of the Hengduan Mountains is a typical region of mountainous landscape in western China and is the core region of "Shangri-La", a world-famous ecotourism destination. The landscape classification system is an important scientific basis for landscape protection and tourism development in this region. By combining geology and geography and referring to the concepts of "system tract" and "tectonic system" in geology, this paper comes up with grading standards for the geoscience landscape system of this region. Based on the regional stratigraphic structure, tectonic fault marks and geomorphological differentiation, this paper comes up with 2 Grade Ⅰ geoscience landscape system tracts, 8 Grade Ⅱ geoscience landscape systems, 21 Grade Ⅲ geoscience landscape areas, and 165 representative Grade Ⅳ geoscience landscape attractions. According to the main classification methods for the geological heritage and tourism landscapes, the geoscience landscapes can be divided into 4 categories, 16 types and 19 subtypes. On this basis, 23 eco-tourism areas of the mid-southern section of the Hengduan Mountains can be delimited. The study provides a theoretical direction and method reference for the geoscience landscape division and tourism zonation, which has an importantsignificance on the mountain landscape protection and tourism development in the regions of complex geo-environments.展开更多
文摘Objective To investigate the expression profiles and their clinical significance of TRAIL receptors (TRAILR) in human hepatocellular carcinoma (HCC). Methods The expression profiles of TRAILR were determined in 60 samples from hepatocellular carcinoma, 20 from normal liver tissue and two HCC cell lines HepG2, SMMC-7721 by in situ hybridization. Results Both DR4 and DR5 were present in all HCC tissues as well as normal hepatic tissues. In contrast, 54 HCC tissues did not express DcR1 and 25 did not express DcR2. But both DcR were detectable in all of the normal liver tissues. The expression patterns of DR and DcR in HCC samples (higher DR expression level and lower DcR expression level) were quite different from those in normal tissue. DR5, DR4, and DcR2 expressed in both cell lines, while no DcR1 expression was detected. The expression level of DR was correlated with HCC differentiation and stage. The weaker expression was more commonly found in HCC with poor differentiation and late stage, while the stronger expression was more common in HCC with middle to high-differentiation and early stage. No relationship was found between DR and gender, age, negative or positive HBsAg, tumor size, grade or metastasis. Multidrug resistance cell lines expressed lower level DR. Conclusion TRAILR expression was prevalent and discrepancy of receptor types was exited in HCC. Loss of DcR1 may contribute for TRAIL therapy for HCC. Key words TRAILR - apoptosis - hepatocellular carcinoma Supported by the Major Fundation of Ministry of Health, NO. 2001–2003
基金supported by the Sichuan Tourism Youth Expert Training Program in Sichuan Provincial Tourism Development Committee (Grant No. SCTYETP2017L05) the Young Scholars Training Program in Chengdu University of Technology (Grant No. KYGG201424)
文摘The mid-southern section of the Hengduan Mountains is a typical region of mountainous landscape in western China and is the core region of "Shangri-La", a world-famous ecotourism destination. The landscape classification system is an important scientific basis for landscape protection and tourism development in this region. By combining geology and geography and referring to the concepts of "system tract" and "tectonic system" in geology, this paper comes up with grading standards for the geoscience landscape system of this region. Based on the regional stratigraphic structure, tectonic fault marks and geomorphological differentiation, this paper comes up with 2 Grade Ⅰ geoscience landscape system tracts, 8 Grade Ⅱ geoscience landscape systems, 21 Grade Ⅲ geoscience landscape areas, and 165 representative Grade Ⅳ geoscience landscape attractions. According to the main classification methods for the geological heritage and tourism landscapes, the geoscience landscapes can be divided into 4 categories, 16 types and 19 subtypes. On this basis, 23 eco-tourism areas of the mid-southern section of the Hengduan Mountains can be delimited. The study provides a theoretical direction and method reference for the geoscience landscape division and tourism zonation, which has an importantsignificance on the mountain landscape protection and tourism development in the regions of complex geo-environments.
