Objective: To evaluate the effects of hippocampal damages on P300 of event-re lated potentials (ERPs). Methods: ERPs were recorded over about 8 months using t he auditory oddball paradigm in a patient with bilateral h...Objective: To evaluate the effects of hippocampal damages on P300 of event-re lated potentials (ERPs). Methods: ERPs were recorded over about 8 months using t he auditory oddball paradigm in a patient with bilateral hippocampal lesions con firmed on brain magnetic resonance imaging. Findings were compared with those from clinical electroencephalography (period ic lateralized epileptiform discharges (PLEDs) or bilateral independent PLEDs (B IPLE- Ds). The patient displayed no marked clinical symptoms aside from mild memory impairment during this time, and was able to fully perform the oddball task.Resu lts: Clearly identifiable P300 were present in all recordings.Furthermore, incre ases in the number of right PLEDs were significantly correlated with increases i n P300 latency.Conclusions: Two key results were apparent. First, the appearance of P300 in all ERP recordings supports the suggestion that the hippocampus is n ot indispensable for P300 generation.Sec- ond, the correlation between the number of PLEDs and P300 latency supports the suggestion that the hippocampus affect the components of P300 latency. Signific ance: This case thus offers very suggestive evidence regarding the generation of P300.展开更多
文摘Objective: To evaluate the effects of hippocampal damages on P300 of event-re lated potentials (ERPs). Methods: ERPs were recorded over about 8 months using t he auditory oddball paradigm in a patient with bilateral hippocampal lesions con firmed on brain magnetic resonance imaging. Findings were compared with those from clinical electroencephalography (period ic lateralized epileptiform discharges (PLEDs) or bilateral independent PLEDs (B IPLE- Ds). The patient displayed no marked clinical symptoms aside from mild memory impairment during this time, and was able to fully perform the oddball task.Resu lts: Clearly identifiable P300 were present in all recordings.Furthermore, incre ases in the number of right PLEDs were significantly correlated with increases i n P300 latency.Conclusions: Two key results were apparent. First, the appearance of P300 in all ERP recordings supports the suggestion that the hippocampus is n ot indispensable for P300 generation.Sec- ond, the correlation between the number of PLEDs and P300 latency supports the suggestion that the hippocampus affect the components of P300 latency. Signific ance: This case thus offers very suggestive evidence regarding the generation of P300.
