目的比较经胸体外单、双相波除颤对犬心肌的损伤程度。方法健康成年杂种犬13只,随机分为单相波除颤组(A组)7只、双相波除颤组(B组)6只。两组均经右颈外静脉置管至右心室诱发室颤,15 s后给予除颤。除颤前后记录Ⅱ导联ST段改变情况;用ELIS...目的比较经胸体外单、双相波除颤对犬心肌的损伤程度。方法健康成年杂种犬13只,随机分为单相波除颤组(A组)7只、双相波除颤组(B组)6只。两组均经右颈外静脉置管至右心室诱发室颤,15 s后给予除颤。除颤前后记录Ⅱ导联ST段改变情况;用ELISA法测定每组除颤前及窦性心律恢复后15、30、60 m in血清心型脂肪酸结合蛋白(H-FABP)含量,除颤前及窦性心律恢复后4、6、8 h血清肌钙蛋白I(cTnI)含量;观察72 h后心脏病理形态学改变。结果 A组6只ST段明显压低或抬高,有的伴有T波倒置;B组1只发生ST段上斜性压低,且很快恢复到基线水平,两组比较有统计学意义(P=0.029)。两组除颤后H-FABP立即升高,15 m in达高峰,30 m in已下降,B组与A组相比各时间点均明显降低(P<0.05)。cTnI除颤后4 h已出现,并呈上升趋势,8 h后B组明显低于A组(P<0.01)。与A组相比,B组心脏损伤病理学改变明显减轻。结论除颤能量与次数相同的情况下,双相波除颤引发的心肌损伤较单相波除颤轻。展开更多
In 1996 the United States Food and Drug Administration approved the first biphasic waveform for external defibrillation after the safety and efficacy of biphasic waveforms had been well-established for defibrillation ...In 1996 the United States Food and Drug Administration approved the first biphasic waveform for external defibrillation after the safety and efficacy of biphasic waveforms had been well-established for defibrillation with internal cardioverter-defibrillators (ICDs). The first approved waveform was incorporated in an automated external defibrillator (AED) marketed as the ForeRunner ((Philips Medical Systems,展开更多
文摘目的比较经胸体外单、双相波除颤对犬心肌的损伤程度。方法健康成年杂种犬13只,随机分为单相波除颤组(A组)7只、双相波除颤组(B组)6只。两组均经右颈外静脉置管至右心室诱发室颤,15 s后给予除颤。除颤前后记录Ⅱ导联ST段改变情况;用ELISA法测定每组除颤前及窦性心律恢复后15、30、60 m in血清心型脂肪酸结合蛋白(H-FABP)含量,除颤前及窦性心律恢复后4、6、8 h血清肌钙蛋白I(cTnI)含量;观察72 h后心脏病理形态学改变。结果 A组6只ST段明显压低或抬高,有的伴有T波倒置;B组1只发生ST段上斜性压低,且很快恢复到基线水平,两组比较有统计学意义(P=0.029)。两组除颤后H-FABP立即升高,15 m in达高峰,30 m in已下降,B组与A组相比各时间点均明显降低(P<0.05)。cTnI除颤后4 h已出现,并呈上升趋势,8 h后B组明显低于A组(P<0.01)。与A组相比,B组心脏损伤病理学改变明显减轻。结论除颤能量与次数相同的情况下,双相波除颤引发的心肌损伤较单相波除颤轻。
文摘In 1996 the United States Food and Drug Administration approved the first biphasic waveform for external defibrillation after the safety and efficacy of biphasic waveforms had been well-established for defibrillation with internal cardioverter-defibrillators (ICDs). The first approved waveform was incorporated in an automated external defibrillator (AED) marketed as the ForeRunner ((Philips Medical Systems,
