Luminescent quantum dots(QDs) are a promising alternative to organic dyes for biomedical assays and imaging. A new conjugation method, NHS mediated conjugating, for QDs and BSA was introduced. The QDs-BSA conjugates w...Luminescent quantum dots(QDs) are a promising alternative to organic dyes for biomedical assays and imaging. A new conjugation method, NHS mediated conjugating, for QDs and BSA was introduced. The QDs-BSA conjugates were confirmed, and their stability has been proved. Caenorhabditis elegans(C. elegans) were used as animal models, and the imaging of QDs in the organism was studied.展开更多
A novel sensing system based on fluorescence resonance energy transfer (FRET) between CdTe quantum dots (QDs) and Rhoda-mine B (RB) was established for the detection of matrix metalloproteinases (MMOL/LPs). In this sy...A novel sensing system based on fluorescence resonance energy transfer (FRET) between CdTe quantum dots (QDs) and Rhoda-mine B (RB) was established for the detection of matrix metalloproteinases (MMOL/LPs). In this system, 535-nm-emitting quantum dots (QDs) were bound to Rhodamine B (RB) via a MMOL/LP-specific peptide. A 76% reduction in luminescence was achieved because of FRET. Release of RBs by peptide cleavage restores radiative QD photoluminescence. Initial studies observed a 73% rise in luminescence over 60 min. The design platform of the nanosensor is flexible and can be fine-tuned for a wide array of applications such as the detection of biomarkers, early diagnosis of disease, and monitoring therapeutic efficacy simply by changing the sequence of the peptide linker.展开更多
Research on white light-emitting diodes(LEDs) based on multi-color-emitting quantum dots(QDs) is carried out in this Letter.The equations of luminous efficiency(LE),color rendering index(CRI),chromaticity coordinates(...Research on white light-emitting diodes(LEDs) based on multi-color-emitting quantum dots(QDs) is carried out in this Letter.The equations of luminous efficiency(LE),color rendering index(CRI),chromaticity coordinates(x,y),and color temperature(T_c) of white LEDs are obtained,according to the spectral-LE function Φof LED chips and QDs.The calculated results indicate that the values of the performance parameters of QD-based white LEDs are closely related and proportional to the QDs' fluorescence spectra,and white LEDs with a high LE and a high CRI may be fabricated based on QDs.We have provided theoretical guidance for preparing such white LEDs.展开更多
基金Supported by the National Natural Science Foundation of China under Grant Nos 60625405 and 10734060, and the National Basic Research Program of China under Grant No 2006CB921504.
文摘Luminescent quantum dots(QDs) are a promising alternative to organic dyes for biomedical assays and imaging. A new conjugation method, NHS mediated conjugating, for QDs and BSA was introduced. The QDs-BSA conjugates were confirmed, and their stability has been proved. Caenorhabditis elegans(C. elegans) were used as animal models, and the imaging of QDs in the organism was studied.
基金supported by the National Natural Science Foundation of China (81000666, 81071194 and 81171395)the Major Project of the Ministry of Science and Technology for New Drug Development (2009ZX-09310-004)
文摘A novel sensing system based on fluorescence resonance energy transfer (FRET) between CdTe quantum dots (QDs) and Rhoda-mine B (RB) was established for the detection of matrix metalloproteinases (MMOL/LPs). In this system, 535-nm-emitting quantum dots (QDs) were bound to Rhodamine B (RB) via a MMOL/LP-specific peptide. A 76% reduction in luminescence was achieved because of FRET. Release of RBs by peptide cleavage restores radiative QD photoluminescence. Initial studies observed a 73% rise in luminescence over 60 min. The design platform of the nanosensor is flexible and can be fine-tuned for a wide array of applications such as the detection of biomarkers, early diagnosis of disease, and monitoring therapeutic efficacy simply by changing the sequence of the peptide linker.
基金This work was supported by the National Basic Research Program of China （973 Program） （No. 2013CB834704）, the National Natural Science Foundation of China （No. 61275190）, the Program of Zhejiang Leading Team of Science and Technology Innovation （No. 2010R50007）, the Fundamental Research Funds for the Central Universities, the Open Fund of the State Key Laboratory of Luminescent Materials and Devices （South China University of Technology）, and the Research Grants Council of Hong Kong （No. HKUST2/CRF/10）.
基金supported by the National Natural Science Foundation of China under Grant Nos.61571105 and 61223001
文摘Research on white light-emitting diodes(LEDs) based on multi-color-emitting quantum dots(QDs) is carried out in this Letter.The equations of luminous efficiency(LE),color rendering index(CRI),chromaticity coordinates(x,y),and color temperature(T_c) of white LEDs are obtained,according to the spectral-LE function Φof LED chips and QDs.The calculated results indicate that the values of the performance parameters of QD-based white LEDs are closely related and proportional to the QDs' fluorescence spectra,and white LEDs with a high LE and a high CRI may be fabricated based on QDs.We have provided theoretical guidance for preparing such white LEDs.
