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胃鳞状细胞癌发生来源及机制研究进展
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作者 姚仕伟 余晗 《局解手术学杂志》 2024年第10期841-844,共4页
胃鳞状细胞癌是一种罕见的胃恶性肿瘤,由于其早期症状不明显,发现时多已处于晚期,因此其治疗效果欠佳、预后相对较差。虽然该疾病目前有明确的诊断标准,但是对于其发生来源和机制尚无明确统一的认识。目前关于胃鳞状细胞癌的发生机制,... 胃鳞状细胞癌是一种罕见的胃恶性肿瘤,由于其早期症状不明显,发现时多已处于晚期,因此其治疗效果欠佳、预后相对较差。虽然该疾病目前有明确的诊断标准,但是对于其发生来源和机制尚无明确统一的认识。目前关于胃鳞状细胞癌的发生机制,多数学者相对认可胃黏膜上皮鳞状细胞化生这一学说,其他学说如多能干细胞的转化、异位鳞状细胞、腺癌向鳞状细胞分化及其他原因引起的鳞状细胞癌发生等则仍需要更多的研究来进一步证明。本文主要对上述学说的发生来源和机制进行阐述总结,以期为后续的研究提供参考。 展开更多
关键词 胃癌 鳞状细胞癌 发生来源 机制
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从人软骨提取总RNA和CDMP-1成熟肽片段的克隆 被引量:2
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作者 马秦 邱蔚六 +3 位作者 费俭 李文刚 陈富林 徐蓬 《上海第二医科大学学报》 CSCD 2000年第6期509-511,共3页
目的克隆人软骨来源形态发生蛋白 - 1(CDMP - 1)成熟肽编码区的基因片段。 方法用异硫氰酸胍一步法从人软骨组织和酶消化法原代培养的软骨细胞中分别抽提总RNA ,利用RT -PCR方法扩增出人CDMP -1成熟区的基因片段 (约 1.0kbp) ,将所得... 目的克隆人软骨来源形态发生蛋白 - 1(CDMP - 1)成熟肽编码区的基因片段。 方法用异硫氰酸胍一步法从人软骨组织和酶消化法原代培养的软骨细胞中分别抽提总RNA ,利用RT -PCR方法扩增出人CDMP -1成熟区的基因片段 (约 1.0kbp) ,将所得基因片段插入 pBluescript质粒载体 ,重组质粒DNA ,通过酶切分析和核苷酸序列分析鉴定阳性克隆。 结果从软骨组织直接抽取到总RNA ,其质量与从等重量软骨组织中的原代软骨细胞所抽取的基本一致 ,人CDMP - 1酶切图谱正确 ,测序得到的部分序列与基因库公布序列一致。 结论从软骨组织可以直接抽取总RNA ,克隆到人CDMP - 1成熟肽编码区的基因片段。 展开更多
关键词 软骨来源形态发生蛋白-1 软骨组织 RT-PCR
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Coseismic slip distribution of 2009 L'Aquila earthquake derived from InSAR and GPS data 被引量:3
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作者 WANG Yong-zhe ZHU Jian-jun +2 位作者 OU Zi-qiang LI Zhi-wei XING Xue-min 《Journal of Central South University》 SCIE EI CAS 2012年第1期244-251,共8页
To better understand the mechanism of the Mw6.3 L'Aquila (Central Italy) earthquake occurred in 2009, global positioning system (GPS) and interferometric synthetic aperture radar (InSAR) data were used to deriv... To better understand the mechanism of the Mw6.3 L'Aquila (Central Italy) earthquake occurred in 2009, global positioning system (GPS) and interferometric synthetic aperture radar (InSAR) data were used to derive the coseismic slip distribution of the earthquake fault. Firstly, based on the homogeneous elastic half-space model, the fault geometric parameters were solved by the genetic algorithm. The best fitting model shows that the fault is a 13.7 km×14.1 km rectangular fault, in 139.3° strike direction and 50.2° southwest-dipping. Secondly, fixing the optimal fault geometric parameters, the fault plane was extended and discretized into 16× 16 patches, each with a size of 1 kmx 1 krn, and the non-uniform slip distribution of the fault was inverted by the steepest descent method with an appropriate smoothing ratio based on the layered crustal structure model. The preferred solution shows that the fault is mainly a normal fault with slight right-lateral strike slip, the maximum slip of 1.01 m is located in the depth of 8.28 km, the average rake is -100.9°, and the total geodetic moment is about 3.34× 1018 N.m (Mw 6.28). The results are much closer than previous studies in comparison with the seismological estimation. These demonstrate that the coseismic fault slip distribution of the L'Aauila earthauake inverted by the crustal model considering layered characters is reliable. 展开更多
关键词 L'Aquila earthquake interferometric synthetic aperture radar global positioning system (GPS) slip distribution
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Age and Some Genetic Characteristics of Vertisols in China 被引量:2
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作者 ZHANGMIN LIULIANG-WU 《Pedosphere》 SCIE CAS CSCD 1993年第1期81-88,共8页
The ages of organic matter of some dark-colored horizons and calcareous concretions in some Vertisols from tropical, subtropical and warm-temperate zones of China were studied using radiocarb on dating method. The rel... The ages of organic matter of some dark-colored horizons and calcareous concretions in some Vertisols from tropical, subtropical and warm-temperate zones of China were studied using radiocarb on dating method. The relationship between soil age and genesis of Vertisols was also expounded based on the study of their genetic charactens-tics and micromorphological features. The results show that although Vertisols have developed for a relatively long time, their weathering and soil forming process are weak and young with little horizonation. This is closely related to their special geochemical soil forming environment. Low-lying terrain, heavy texture, clay minerals dominated by montmorillonites and alternative drying- wetting climate give rise to the vertic features expressed in intense swelling-shrinking and cracking-closing in soils. As a result, the soil development and soil leaching process are resisted, and the climatic effect on the horizonation is impeded. Moreover, pedoturbation eliminates the horizonation in the upper part of soil profile, and postpones their evolution into zonal soils. So Vertisols show certain pedogenic inertia and stay at relatively young developmental stage. Therefore, Vertisols are intrazonal soils dominated by local soil forming factors such as the relief and parent materials. 展开更多
关键词 soil age soil genesis soil micromorphology Vcrtisols
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Responses of Hyalella Azteca to Chronic Exposure of Mississippi Delta Sediments
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作者 S.S. Knight R.E. Lizotte S. Smith C.T. Bryant 《Journal of Environmental Science and Engineering》 2010年第3期1-12,共12页
Hyalella azteca was used to assess biological impairment in sediments from nine water bodies in the Mississippi Delta (i.e., lower Mississippi alluvial plain). Water bodies were categorized according to land use and... Hyalella azteca was used to assess biological impairment in sediments from nine water bodies in the Mississippi Delta (i.e., lower Mississippi alluvial plain). Water bodies were categorized according to land use and implementation of agricultural best management practices (BMPs). Sediment samples were collected at three sites within each water body from June to July 2004 and analyzed for 17 current and historic-use pesticides and metabolites. Twenty-eight day H. azteca survival and growth were measured to assess the degree of biological impairment. No significant (P 〉 0.05) mortality occurred in animals exposed to sediments. Significant growth impairment was observed in sediments from all three 303(d) listed water bodies and two of three BMP oxbow lakes. Historic-use pesticides and metabolites were implicated in two of five biologically impaired water bodies. Complex contaminant mixtures often limit attempts to provide clear, definitive sources of biological impairment. In this study, even accounting for sediment characteristics such as sand-silt-clay fractions and organic carbon content did not further clarify sources of toxicity in some water bodies. Finally, results show that implementation of BMPs can mitigate biological impairment within lake sediments. 展开更多
关键词 Hyalella azteca chronic toxicity SEDIMENT PESTICIDES Mississippi Delta.
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Right to Health or the Human Right of Access to Essential Healthcare
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作者 Nader Ghotbi 《Journal of Philosophy Study》 2013年第6期529-537,共9页
The Universal Declaration of Human Rights refers to the human right to health and well-being including medical care, but for the majority of people whom are not covered by health insurance this is better said than don... The Universal Declaration of Human Rights refers to the human right to health and well-being including medical care, but for the majority of people whom are not covered by health insurance this is better said than done. Ensuring the access of all citizens to the needed medical care requires the provision of health insurance coverage to a population pool and gradually expanding the pool to the whole nation. The ethical perspective of pooling resources across various groups of people with different levels of income and different health risks associated with age, genetics, and lifestyle, may raise the issue of individual autonomy versus social solidarity. Governmental, social, private, and community-based healthcare coverage have been used in different countries with varying details in the sources of funding, pooling of contributions, and the purchase of the covered healthcare services; these models have had varying levels of success depending on not only the availability of funds, but also on the political commitment of the state and the social solidarity and cultural attitude of the population towards universal healthcare. Therefore, universal healthcare requires not only a certain level of economic development, but also a strong sense of solidarity among the people as well as a political commitment in their government. I argue that the statement regarding the right to health, well-being, and medical care needs to be rethought, and instead universal access to essential healthcare should be regarded as a basic human right. 展开更多
关键词 health insurance health security healthcare access human rights social solidarity universal healthcoverage
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