Thyroid hemiagenesis is a rare form of thyroid dysgenesis of which some familial cases have been reported, including one associated with a heterozygous mutation in the Pax8 gene. However, the physiopathology remains n...Thyroid hemiagenesis is a rare form of thyroid dysgenesis of which some familial cases have been reported, including one associated with a heterozygous mutation in the Pax8 gene. However, the physiopathology remains not well known. The objectives of this study were 1) to describe the clinical features, 2) to look for familial clustering, and 3) to search for Pax8 mutations in a relatively large cohort of affected patients. A family history of thyroid dysgenesis was found in nine patients (40% ), whose affected relatives had ectopic thyroid (n = 4), athyreosis (n = 1), thyroid hemiagenesis (n = 2), or thyroglossal duct cysts (n = 2). Screening for Pax8 mutations identified abnormal migration profiles by SSCP analysis in 3 patients, but direct sequencing did not show coding region mutations in any of the 22 patients. In conclusion, this study provides the first evidence that thyroid hemiagenesis can occur as a familial disorder associated with any form of thyroid dysgenesis. This finding supports both a common underlying mechanism to the various abnormalities in thyroid development and a role for genetic factors; however, our results from Pax8 analysis suggest that this gene may not be a key factor.展开更多
A fuzzy neural network controller with the teaching controller guidance and parameter regulations for vector-controlled induction motor is proposed. The design procedures of the fuzzy neural controller and the teachin...A fuzzy neural network controller with the teaching controller guidance and parameter regulations for vector-controlled induction motor is proposed. The design procedures of the fuzzy neural controller and the teaching controller are described. The parameters of the membership function are regulated by an on-line learning algorithm. The speed responses of the system under the condition, where the target functions are chosen as I qs and ω, are analyzed. The system responses with the variant of parameter moment of inertial J, viscous coefficients B and torque constant K tare also analyzed. Simulation results show that the control scheme and the controller have the advantages of rapid speed response and good robustness.展开更多
文摘Thyroid hemiagenesis is a rare form of thyroid dysgenesis of which some familial cases have been reported, including one associated with a heterozygous mutation in the Pax8 gene. However, the physiopathology remains not well known. The objectives of this study were 1) to describe the clinical features, 2) to look for familial clustering, and 3) to search for Pax8 mutations in a relatively large cohort of affected patients. A family history of thyroid dysgenesis was found in nine patients (40% ), whose affected relatives had ectopic thyroid (n = 4), athyreosis (n = 1), thyroid hemiagenesis (n = 2), or thyroglossal duct cysts (n = 2). Screening for Pax8 mutations identified abnormal migration profiles by SSCP analysis in 3 patients, but direct sequencing did not show coding region mutations in any of the 22 patients. In conclusion, this study provides the first evidence that thyroid hemiagenesis can occur as a familial disorder associated with any form of thyroid dysgenesis. This finding supports both a common underlying mechanism to the various abnormalities in thyroid development and a role for genetic factors; however, our results from Pax8 analysis suggest that this gene may not be a key factor.
文摘A fuzzy neural network controller with the teaching controller guidance and parameter regulations for vector-controlled induction motor is proposed. The design procedures of the fuzzy neural controller and the teaching controller are described. The parameters of the membership function are regulated by an on-line learning algorithm. The speed responses of the system under the condition, where the target functions are chosen as I qs and ω, are analyzed. The system responses with the variant of parameter moment of inertial J, viscous coefficients B and torque constant K tare also analyzed. Simulation results show that the control scheme and the controller have the advantages of rapid speed response and good robustness.
