The influence of water on protein conformation was investigated by simulating the molecular dynamics of a model protein lysozyme in different water systems.The lysozyme-water system with TIP3P water model and lysozyme...The influence of water on protein conformation was investigated by simulating the molecular dynamics of a model protein lysozyme in different water systems.The lysozyme-water system with TIP3P water model and lysozyme-water cluster system with six-ring water model were evaluated.In addition,the radial distribution function of solvent around lysozyme was calculated.It is found that the distribution of water molecules around lysozyme is similar to that of water clusters.The analyses of dihedral angles and disulfide bonds of lysozyme show that the conformation of lysozyme is severely damaged in the lysozyme-water cluster system compared with that in the lysozyme-water system.This difference can be attributed to the formation of larger number of intermolecular hydrogen bonds between lysozyme and water cluster.It is in agreement with the analysis that water clusters can change the degree of denaturation in the process of heat denaturation of lysozyme.展开更多
Peripheral nerve injuries affect a wide range of functional,manual and social function,and frequently lead to constant disabilities.After complete transection of nerve,axonal degeneration process gives rise to a varie...Peripheral nerve injuries affect a wide range of functional,manual and social function,and frequently lead to constant disabilities.After complete transection of nerve,axonal degeneration process gives rise to a variety of symptoms including hyperesthesia,reduced or altered sensation,pain and atrophy(Lee and Wolfe,2000).With an array of choices for surgical and展开更多
The generation of mice lacking SCYL1 or SCYL2 and the identification of Scyl1 as the causative gene in the motor neuron disease mouse model muscle deficient(Scyl1^(mdf/mdf)) demonstrated the importance of the SCY1-lik...The generation of mice lacking SCYL1 or SCYL2 and the identification of Scyl1 as the causative gene in the motor neuron disease mouse model muscle deficient(Scyl1^(mdf/mdf)) demonstrated the importance of the SCY1-like family of protein pseudokinases in neuronal function and survival.Several essential cellular processes such as intracellular trafficking and nuclear tRNA export are thought to be regulated by SCYL proteins.However,whether deregulation of these processes contributes to the neurodegenerative processes associated with the loss of SCYL proteins is still unclear.Here,I briefly review the evidence supporting that SCYL proteins play a role in these processes and discuss their possible involvement in the neuronal functions of SCYL proteins.I also propose ways to determine the importance of these pathways for the functions of SCYL proteins in vivo.展开更多
Peripheral nerve injury causes a partial or total loss of motor and sensory functions as a result of axonal disruption and subsequent axonal disintegration as well as denervation distal from the point of injury.Althou...Peripheral nerve injury causes a partial or total loss of motor and sensory functions as a result of axonal disruption and subsequent axonal disintegration as well as denervation distal from the point of injury.Although peripheral nerves are,in contrast to the central nervous system,able to regenerate and reinnervate,functionality is not always restored completely due to insufficient reinnervation or remyelination,and injury may result in sequelae such as neuropathic pain.展开更多
The authors report the longitudinal case study of a patient with the right temporal variant of frontotemporal lobar degeneration. His deficit, initially limited to visuoperceptual disturbances, progressed 2 years late...The authors report the longitudinal case study of a patient with the right temporal variant of frontotemporal lobar degeneration. His deficit, initially limited to visuoperceptual disturbances, progressed 2 years later to a severe semantic breakdown. Neuroimaging data indicate that the underlying degenerative process, initially confined to unimodal visual associative cortices, progressed along the ventral pathways to multimodal areas in charge of integrating knowledge from various modalities (the anterior temporal lobes).展开更多
基金Supported by National Natural Science Foundation of China (No. 20676094)
文摘The influence of water on protein conformation was investigated by simulating the molecular dynamics of a model protein lysozyme in different water systems.The lysozyme-water system with TIP3P water model and lysozyme-water cluster system with six-ring water model were evaluated.In addition,the radial distribution function of solvent around lysozyme was calculated.It is found that the distribution of water molecules around lysozyme is similar to that of water clusters.The analyses of dihedral angles and disulfide bonds of lysozyme show that the conformation of lysozyme is severely damaged in the lysozyme-water cluster system compared with that in the lysozyme-water system.This difference can be attributed to the formation of larger number of intermolecular hydrogen bonds between lysozyme and water cluster.It is in agreement with the analysis that water clusters can change the degree of denaturation in the process of heat denaturation of lysozyme.
文摘Peripheral nerve injuries affect a wide range of functional,manual and social function,and frequently lead to constant disabilities.After complete transection of nerve,axonal degeneration process gives rise to a variety of symptoms including hyperesthesia,reduced or altered sensation,pain and atrophy(Lee and Wolfe,2000).With an array of choices for surgical and
基金support from the American Lebanese Syrian Associated Charities
文摘The generation of mice lacking SCYL1 or SCYL2 and the identification of Scyl1 as the causative gene in the motor neuron disease mouse model muscle deficient(Scyl1^(mdf/mdf)) demonstrated the importance of the SCY1-like family of protein pseudokinases in neuronal function and survival.Several essential cellular processes such as intracellular trafficking and nuclear tRNA export are thought to be regulated by SCYL proteins.However,whether deregulation of these processes contributes to the neurodegenerative processes associated with the loss of SCYL proteins is still unclear.Here,I briefly review the evidence supporting that SCYL proteins play a role in these processes and discuss their possible involvement in the neuronal functions of SCYL proteins.I also propose ways to determine the importance of these pathways for the functions of SCYL proteins in vivo.
文摘Peripheral nerve injury causes a partial or total loss of motor and sensory functions as a result of axonal disruption and subsequent axonal disintegration as well as denervation distal from the point of injury.Although peripheral nerves are,in contrast to the central nervous system,able to regenerate and reinnervate,functionality is not always restored completely due to insufficient reinnervation or remyelination,and injury may result in sequelae such as neuropathic pain.
文摘The authors report the longitudinal case study of a patient with the right temporal variant of frontotemporal lobar degeneration. His deficit, initially limited to visuoperceptual disturbances, progressed 2 years later to a severe semantic breakdown. Neuroimaging data indicate that the underlying degenerative process, initially confined to unimodal visual associative cortices, progressed along the ventral pathways to multimodal areas in charge of integrating knowledge from various modalities (the anterior temporal lobes).
基金This work was supported by the National Natural Science Foundation of China （No. 30973025）, Ministry of Health Funding for Research and Special Projects Public Service Sectors （No. 201002018）, Anhui Province Education Department Natural Science Key Foundation of China （No. KJ2010A320）.
