A 32- year- old patient with seizures experienced decreased right- ear hearing during electrocortical stimulation mapping of the left lateral superior temporal gyrus. Audiometric testing under headphones confirmed a r...A 32- year- old patient with seizures experienced decreased right- ear hearing during electrocortical stimulation mapping of the left lateral superior temporal gyrus. Audiometric testing under headphones confirmed a reversible, moderate unilateral hearing loss. Under binaural listening conditions, auditory comprehension was impaired at the same site, whereas word repetition, environmental sound recognition, naming, and spontaneous speech remained intact.展开更多
孕激素（progestogen）（Ⅰ）作为激素替代治疗（HRT）的一部分，可能加重妇女的年龄相关听力丧失，这一结论是在与雌激素（eserogen）（Ⅱ）单药HRT和元HRT患者进行比较后得出的，研究报告在线发表于《美国科学院院刊》（Proceedings...孕激素（progestogen）（Ⅰ）作为激素替代治疗（HRT）的一部分，可能加重妇女的年龄相关听力丧失，这一结论是在与雌激素（eserogen）（Ⅱ）单药HRT和元HRT患者进行比较后得出的，研究报告在线发表于《美国科学院院刊》（Proceedings of the National Academy of Sciences）上。展开更多
Objective: To determine the relationship between the virus burden in infancy a nd hearing loss in congenital CMV infection. Study design: A cohort of 76 infant s with congenital cytomegalovirus (CMV) infection identif...Objective: To determine the relationship between the virus burden in infancy a nd hearing loss in congenital CMV infection. Study design: A cohort of 76 infant s with congenital cytomegalovirus (CMV) infection identified by means of newborn virologic screening was monitored for outcome. The amount of infectious CMV was analyzed in urine specimens obtained during early infancy. Peripheral blood (PB ) samples obtained during early infancy were available from 75 children and CMV DNA was quantitated with a real-time quantitative polymerase chain reaction. Re sults: Infants with clinical abnormalities at birth (symptomatic congenital CMV infection) had higher amounts of CMV in urine (P =. 005) and CMV DNA in PB (P =. 001) than infants with no symptoms. Eight children with and 4 children without symptoms had hearing loss. Among children without symptoms, those with hearing l oss had a significantly greater amount of CMV in urine (P =. 03) and PB virus bu rden (P =. 02) during infancy than those with normal hearing. Infants with < 5 ×103 pfu/mL of urine CMV and infants with < 1 ×104 copies/mL of viral DNA in P B were at a lower risk for hearing loss. Conclusion: In children with asymptomat ic congenital CMV infection, hearing loss was associated with increased amounts of urine CMV and PB CMV DNA during early infancy.展开更多
In a study of the possible inter-relationship among müllerian anomalies,hearing loss,and connexin 26 mutations,we evaluated all women in whom müllerian anomalies were diagnosed on hysterosalpingography durin...In a study of the possible inter-relationship among müllerian anomalies,hearing loss,and connexin 26 mutations,we evaluated all women in whom müllerian anomalies were diagnosed on hysterosalpingography during a 6-year period (n=24/519). Audiometric testing revealed five (22.7%) with unrecognized sensorineural hearing loss; however,on genetic evaluation,none harbored a connexin 26 mutation.展开更多
文摘A 32- year- old patient with seizures experienced decreased right- ear hearing during electrocortical stimulation mapping of the left lateral superior temporal gyrus. Audiometric testing under headphones confirmed a reversible, moderate unilateral hearing loss. Under binaural listening conditions, auditory comprehension was impaired at the same site, whereas word repetition, environmental sound recognition, naming, and spontaneous speech remained intact.
文摘孕激素（progestogen）（Ⅰ）作为激素替代治疗（HRT）的一部分，可能加重妇女的年龄相关听力丧失，这一结论是在与雌激素（eserogen）（Ⅱ）单药HRT和元HRT患者进行比较后得出的，研究报告在线发表于《美国科学院院刊》（Proceedings of the National Academy of Sciences）上。
文摘Objective: To determine the relationship between the virus burden in infancy a nd hearing loss in congenital CMV infection. Study design: A cohort of 76 infant s with congenital cytomegalovirus (CMV) infection identified by means of newborn virologic screening was monitored for outcome. The amount of infectious CMV was analyzed in urine specimens obtained during early infancy. Peripheral blood (PB ) samples obtained during early infancy were available from 75 children and CMV DNA was quantitated with a real-time quantitative polymerase chain reaction. Re sults: Infants with clinical abnormalities at birth (symptomatic congenital CMV infection) had higher amounts of CMV in urine (P =. 005) and CMV DNA in PB (P =. 001) than infants with no symptoms. Eight children with and 4 children without symptoms had hearing loss. Among children without symptoms, those with hearing l oss had a significantly greater amount of CMV in urine (P =. 03) and PB virus bu rden (P =. 02) during infancy than those with normal hearing. Infants with < 5 ×103 pfu/mL of urine CMV and infants with < 1 ×104 copies/mL of viral DNA in P B were at a lower risk for hearing loss. Conclusion: In children with asymptomat ic congenital CMV infection, hearing loss was associated with increased amounts of urine CMV and PB CMV DNA during early infancy.
文摘In a study of the possible inter-relationship among müllerian anomalies,hearing loss,and connexin 26 mutations,we evaluated all women in whom müllerian anomalies were diagnosed on hysterosalpingography during a 6-year period (n=24/519). Audiometric testing revealed five (22.7%) with unrecognized sensorineural hearing loss; however,on genetic evaluation,none harbored a connexin 26 mutation.
