舌嗜酸性溃疡(eosinophilic ulcer of the tongue, EUT)是一种良性反应性疾病,通常呈自限性。该病较为罕见,临床常表现为快速增大的孤立溃疡,易被误诊为恶性肿瘤。本文报道1例持续1月余的舌嗜酸性溃疡,探讨该病的临床特点、组织病理学...舌嗜酸性溃疡(eosinophilic ulcer of the tongue, EUT)是一种良性反应性疾病,通常呈自限性。该病较为罕见,临床常表现为快速增大的孤立溃疡,易被误诊为恶性肿瘤。本文报道1例持续1月余的舌嗜酸性溃疡,探讨该病的临床特点、组织病理学特征及诊治原则,以期为临床诊疗提供参考。展开更多
We report a rare case of hypereosinophilic syndrome （HES） presenting with intractable gastric ulcers. A 71-year-old man was admitted with epigastric pain. Initial endoscopic findings revealed multiple, active gastri...We report a rare case of hypereosinophilic syndrome （HES） presenting with intractable gastric ulcers. A 71-year-old man was admitted with epigastric pain. Initial endoscopic findings revealed multiple, active gastric ulcers in the gastric antrum. He underwent Helicobacterpylori （Hpylon） eradication therapy followed by proton pump inhibitor （PPI） therapy. However, follow- up endoscopy at 4, 6, 10 and 14 mo revealed persistent multiple gastric ulcers without significant improvement. The proportion of his eosinophil count increased to 43% （total count： 7903/mm3）. Abdominal-pelvic and chest computed tomography scans showed multiple small nodules in the liver and both lungs. The endoscopic biopsy specimen taken from the gastric antrum revealed prominent eosinophilic infiltration, and the liver biopsy specimen also showed eosinophilic infiltration in the portal tract and sinusoid. A bone marrow biopsy disclosed eosinophilic hyperplasia as well as increased cellularity of 70%. The patient was finally diagnosed with HES involving the stomach, liver, lung, and bone marrow. When gastric ulcers do not improve despite H pylon eradication and prolonged PPI therapy, infiltrative gastric disorders such as HES should be considered.展开更多
文摘舌嗜酸性溃疡(eosinophilic ulcer of the tongue, EUT)是一种良性反应性疾病,通常呈自限性。该病较为罕见,临床常表现为快速增大的孤立溃疡,易被误诊为恶性肿瘤。本文报道1例持续1月余的舌嗜酸性溃疡,探讨该病的临床特点、组织病理学特征及诊治原则,以期为临床诊疗提供参考。
基金Supported by Chung-Ang University College of Medicine
文摘We report a rare case of hypereosinophilic syndrome （HES） presenting with intractable gastric ulcers. A 71-year-old man was admitted with epigastric pain. Initial endoscopic findings revealed multiple, active gastric ulcers in the gastric antrum. He underwent Helicobacterpylori （Hpylon） eradication therapy followed by proton pump inhibitor （PPI） therapy. However, follow- up endoscopy at 4, 6, 10 and 14 mo revealed persistent multiple gastric ulcers without significant improvement. The proportion of his eosinophil count increased to 43% （total count： 7903/mm3）. Abdominal-pelvic and chest computed tomography scans showed multiple small nodules in the liver and both lungs. The endoscopic biopsy specimen taken from the gastric antrum revealed prominent eosinophilic infiltration, and the liver biopsy specimen also showed eosinophilic infiltration in the portal tract and sinusoid. A bone marrow biopsy disclosed eosinophilic hyperplasia as well as increased cellularity of 70%. The patient was finally diagnosed with HES involving the stomach, liver, lung, and bone marrow. When gastric ulcers do not improve despite H pylon eradication and prolonged PPI therapy, infiltrative gastric disorders such as HES should be considered.
