5-HT1A基因编码5-羟色胺(血清素)的G蛋白偶联受体(属于5-羟色胺受体亚家族)。C-1019G多态位点是5-HT1A基因启动子区一个重要的功能性多态位点,人群中存在3种基因型即CC、CG、GG,它与个体的恋爱关系及抑郁症、焦虑症等精神疾病密切相关...5-HT1A基因编码5-羟色胺(血清素)的G蛋白偶联受体(属于5-羟色胺受体亚家族)。C-1019G多态位点是5-HT1A基因启动子区一个重要的功能性多态位点,人群中存在3种基因型即CC、CG、GG,它与个体的恋爱关系及抑郁症、焦虑症等精神疾病密切相关。本文对5-HT1A基因C-1019G多态位点的相关机制、检测方法、研究进展等进行综述。The 5-HT1A gene encodes a G protein-coupled receptor for serotonin, which belongs to the 5-hydroxytryptamine receptor subfamily. C-1019G polymorphism is an important functional poly-morphism in the promoter region of 5-HT1A gene. There are three genotypes (CC, CG and GG) in the population, which are closely related to individual’s romantic relationship and mental disorders such as depression and anxiety. In this paper, the mechanism, detection methods and research progress of C-1019G polymorphism of 5-HT1A gene were reviewed.展开更多
文摘5-HT1A基因编码5-羟色胺(血清素)的G蛋白偶联受体(属于5-羟色胺受体亚家族)。C-1019G多态位点是5-HT1A基因启动子区一个重要的功能性多态位点,人群中存在3种基因型即CC、CG、GG,它与个体的恋爱关系及抑郁症、焦虑症等精神疾病密切相关。本文对5-HT1A基因C-1019G多态位点的相关机制、检测方法、研究进展等进行综述。The 5-HT1A gene encodes a G protein-coupled receptor for serotonin, which belongs to the 5-hydroxytryptamine receptor subfamily. C-1019G polymorphism is an important functional poly-morphism in the promoter region of 5-HT1A gene. There are three genotypes (CC, CG and GG) in the population, which are closely related to individual’s romantic relationship and mental disorders such as depression and anxiety. In this paper, the mechanism, detection methods and research progress of C-1019G polymorphism of 5-HT1A gene were reviewed.
基金Funded by the National Basic Science Research Program of China(Grant No.2010CB530001)the National Natural Science Foundation of China(Grant No.81471983)~~
