This paper proposes an efficient approximate Maximum Likelihood (ML) detection method for Multiple-Input Multiple-Output (MIMO) systems,which searches local area instead of exhaustive search and selects valid search p...This paper proposes an efficient approximate Maximum Likelihood (ML) detection method for Multiple-Input Multiple-Output (MIMO) systems,which searches local area instead of exhaustive search and selects valid search points in each transmit antenna signal constellation instead of all hy-perplane. Both of the selection and search complexity can be reduced significantly. The method per-forms the tradeoff between computational complexity and system performance by adjusting the neighborhood size to select the valid search points. Simulation results show that the performance is comparable to that of the ML detection while the complexity is only as the small fraction of ML.展开更多
A method of implementing high cost-effective and highly integrated digital lock-in amplifier with microcontroller is discussed. And the digital lock-in amplifier is more suitable for meastwing lowfrequency weak signal...A method of implementing high cost-effective and highly integrated digital lock-in amplifier with microcontroller is discussed. And the digital lock-in amplifier is more suitable for meastwing lowfrequency weak signal. Digital signal sequence is obtained through sampling signal measured over an integer number of signal periods, but digital reference sequence is acquired through mathematical operation, then digital phase sensitive detection can be implemented by calculating the cross-correlation function of digital signal sequence and digital reference sequence. In addition, the frequency response and phase character of the digital lock-in amplifier is analyzed. Finally, the designed digital lock-in amplifier is achieved. Expermental results show that the digital lock-in amplifier can be used for measuring weak signal with low ignal-to-noise ratio.展开更多
A versatile DNA recognition system using cadmium sulfide nanoparticles (CdS NPs) as labels was proposed for ultrasensitive detection of specific sequence DNA based on target recycling. This strategy utilized the magne...A versatile DNA recognition system using cadmium sulfide nanoparticles (CdS NPs) as labels was proposed for ultrasensitive detection of specific sequence DNA based on target recycling. This strategy utilized the magnetic particles (MNPs) for the immobilization of linker DNA and CdS NPs and the subsequent target DNA hybridization. Using the unique characteristic of nicking endonuclease for cutting one specific strand of double strand DNA (ds DNA), the linker DNA could be transected and the target DNA could be liberated for re-hybridization and hence the amount of released CdS NPs was enhanced. Due to the advantage of the MNPs and signal amplification from the target recycling, the analyte DNA could be detected by the square-wave stripping voltammetry (SWV) in a wide linear range from 0.4 fM to 100 fM with the detection limit down to 0.08 fM. The proposed DNA detection strategy possesses high sensitivity, satisfactory reproducibility and excellent stability, which might have potential in other DNA biological assays.展开更多
文摘This paper proposes an efficient approximate Maximum Likelihood (ML) detection method for Multiple-Input Multiple-Output (MIMO) systems,which searches local area instead of exhaustive search and selects valid search points in each transmit antenna signal constellation instead of all hy-perplane. Both of the selection and search complexity can be reduced significantly. The method per-forms the tradeoff between computational complexity and system performance by adjusting the neighborhood size to select the valid search points. Simulation results show that the performance is comparable to that of the ML detection while the complexity is only as the small fraction of ML.
文摘A method of implementing high cost-effective and highly integrated digital lock-in amplifier with microcontroller is discussed. And the digital lock-in amplifier is more suitable for meastwing lowfrequency weak signal. Digital signal sequence is obtained through sampling signal measured over an integer number of signal periods, but digital reference sequence is acquired through mathematical operation, then digital phase sensitive detection can be implemented by calculating the cross-correlation function of digital signal sequence and digital reference sequence. In addition, the frequency response and phase character of the digital lock-in amplifier is analyzed. Finally, the designed digital lock-in amplifier is achieved. Expermental results show that the digital lock-in amplifier can be used for measuring weak signal with low ignal-to-noise ratio.
基金supported by the National Natural Science Foundation of China (21025522 & 20890021)the National Natural Science Foundation of China for Creative Research Groups (20821063)the National Basic Research Program of China (2007CB936404)
文摘A versatile DNA recognition system using cadmium sulfide nanoparticles (CdS NPs) as labels was proposed for ultrasensitive detection of specific sequence DNA based on target recycling. This strategy utilized the magnetic particles (MNPs) for the immobilization of linker DNA and CdS NPs and the subsequent target DNA hybridization. Using the unique characteristic of nicking endonuclease for cutting one specific strand of double strand DNA (ds DNA), the linker DNA could be transected and the target DNA could be liberated for re-hybridization and hence the amount of released CdS NPs was enhanced. Due to the advantage of the MNPs and signal amplification from the target recycling, the analyte DNA could be detected by the square-wave stripping voltammetry (SWV) in a wide linear range from 0.4 fM to 100 fM with the detection limit down to 0.08 fM. The proposed DNA detection strategy possesses high sensitivity, satisfactory reproducibility and excellent stability, which might have potential in other DNA biological assays.
