Idiopathic hypogonadotropic hypogonadism is a rare disease that is characterized by delayed/absent puberty and/or infertility due to an insufficient stimulation of an otherwise normal pituitary-gonadal axis by gonadot...Idiopathic hypogonadotropic hypogonadism is a rare disease that is characterized by delayed/absent puberty and/or infertility due to an insufficient stimulation of an otherwise normal pituitary-gonadal axis by gonadotrophin-releasing hormone （GnRH） action. Because reduced or normal luteinizing hormone （LH）/follicle-stimulating hormone （FSH） levels may be observed in the affected patients, the term idiopathic central hypogonadism （ICH） appears to be more appropriate. This disease should be distinguished from central hypogonadism that is combined with other pituitary deficiencies. Isolated ICH has a complex pathogenesis and ~s fivefold more prevalent in males. ICH frequently appears in a sporadic form, but several familial cases have also been reported. This finding, in conjunction with the description of numerous pathogenetic gene variants and the generation of several knockout models, supports the existence of a strong genetic component. ICH may be associated with several morphogenetic abnormalities, which include osmic defects that, with ICH, constitute the cardinal manifestations of Kallmann syndrome （KS）. KS accounts for approximately 40% of the total ICH cases and has been generally considered to be a distinct subgroup. However, the description of several pedigrees, which include relatives who are affected either with isolated osmic defects, KS, or normo-osmic ICH （nlCH）, justifies the emerging idea that ICH is a complex genetic disease that is characterized by variable expressivity and penetrance. In this context, either multiple gene variants or environmental factors and epigenetic modifications may contribute to the variable disease manifestations. We review the genetic mechanisms that are presently known to be involved in ICH pathogenesis and provide a clinical overview of the 227 cases that have been collected by the collaborating centres of the Italian ICH Network.展开更多
A new,low-cost RFID tag analog front-end compatible with ISO 14443A and ISO 14443B is presented. By substituting conventional multi-circle antenna with single-circle antenna, the package cost of the tag is greatly red...A new,low-cost RFID tag analog front-end compatible with ISO 14443A and ISO 14443B is presented. By substituting conventional multi-circle antenna with single-circle antenna, the package cost of the tag is greatly reduced. Based on this exasperate antenna performance,a new rectifier with high power conversion efficiency and low turn-on voltage is presented. The circuit is implemented in an SMIC 0.18μm EEPROM process. Measurement results show that with a 120kΩ load,the power conversion efficiency reaches as high as 36%. For a sinusoidal wave with magnitude of 0. 5V, the output DC voltage reaches IV,which is high enough for RFID tags. The read distance is as far as 22cm.展开更多
The functional materials based on natural zeolite （clinoptilolite）, TiO2-zeolite and Ag-TiO2-zeolite have been successfully synthesized by solid-state reaction in fast-hydrothermal conditions. The obtained functiona...The functional materials based on natural zeolite （clinoptilolite）, TiO2-zeolite and Ag-TiO2-zeolite have been successfully synthesized by solid-state reaction in fast-hydrothermal conditions. The obtained functional materials were investigated by X-ray diffraction （XRD）, FT-1R （Fourier transform infrared） spectroscopy, DRUV-VIS （diffuse reflectance ultraviolet-visible） spectroscopy, BET （Brunauer-Emmett-Teller） and SEM/EDX （scanning electron microscope/energy dispersive X-ray spectrometer） analyses. The XRD results indicated that the clinoptilolite structure has a good thermal stabilization after the fast-hydrothermal treatment. Also, the high specific surface area about 92.55 m^2.g^-1 was noticed for Ag-TiO2-zeolite functional material. The presence of dopants was evidenced from EDX spectra. The enhanced bactericidal activity of Ag-TiO2-zeolite catalyst is proved through damaging of Enterococcusfaecalis colonies under visible irradiation, at different material doses and irradiation times.展开更多
we demonstrate the adjustability of optimal input power(OIP) of the radio over fiber(RoF) link by proper link gain control in the central unit(CU) and remote antenna unit(RAU).The experiment results show that the read...we demonstrate the adjustability of optimal input power(OIP) of the radio over fiber(RoF) link by proper link gain control in the central unit(CU) and remote antenna unit(RAU).The experiment results show that the reading and writing distance(RWD)of the radio frequency identification(RFID)service and the throughput of the WiFi service have a max increase of 3cm and 6.975Mbit/s respectively when the OIP value equals to output power of commercial products,compared with OIP value with 5-dBm right/left shift to the output power.展开更多
To establish wireless channel suitable for the cabin environment, the power coverage was investigated with distributed antenna system and centralized antenna system based on the actual measurement of channel impulse r...To establish wireless channel suitable for the cabin environment, the power coverage was investigated with distributed antenna system and centralized antenna system based on the actual measurement of channel impulse response. The results indicated that the distributed antenna system has more uniform power coverage than the centralized antenna system. The average relative errors of receiving power of both antennas were calculated. The optimal position of the centralized antenna was obtained by Gaussian function refinement, making the system achieve a better transmission power with the same coverage effect, and providing a reference for antenna location in the future real communication in the cabin.展开更多
The GF-3 satellite was successfully launched at 06：55 Beijing time on August10 using a LM-4C launch vehicle from the Taiyuan Satellite Launch Center.The launch was the 233rd flight of a LM family launch vehicle and t...The GF-3 satellite was successfully launched at 06：55 Beijing time on August10 using a LM-4C launch vehicle from the Taiyuan Satellite Launch Center.The launch was the 233rd flight of a LM family launch vehicle and the carrier rocket LM-4C was developed by the Shanghai Academy of Spaceflight Technology.展开更多
In thsssse cellular network, Relay Stations (RSs) help to improve the system performance; however, little work has been done considering the fairness of RSs. In this paper, we study the cooperative game approaches for...In thsssse cellular network, Relay Stations (RSs) help to improve the system performance; however, little work has been done considering the fairness of RSs. In this paper, we study the cooperative game approaches for scheduling in the wireless relay networks with two-virtual-antenna array mode. After defining the metric of relay channel capacity, we form a cooperative game for scheduling and present the interpretation of three different utilization objectives physically and mathematically. Then, a Nash Bargaining Solution (NBS) is utilized for resource allocation considering the traffic load fairness for relays. After proving the existence and uniqueness of NBS in Cooperative Game (CG-NBS), we are able to resolve the resource allocation problem in the cellular relay network by the relay selection and subcarrier assignment policy and the power allocation algorithm for both RSs and UEs. Simulation results reveal that the proposed CG-NBS scheme achieves better tradeoff between relay fairness and system throughput than the conventional Maximal Rate Optimization and Maximal Minimal Fairness methods.展开更多
On August 2,a twin-segment solid rocket motor of the largest diameter,grain mass and thrust in China completed its ground test firing with success.The3 m solid motor was independently developed by the Academy of Aeros...On August 2,a twin-segment solid rocket motor of the largest diameter,grain mass and thrust in China completed its ground test firing with success.The3 m solid motor was independently developed by the Academy of Aerospace Solid Propulsion Technology（AASPT）under CASC.展开更多
There is a general consensus in re-interpreting the so-called liver function tests in the light of novel discoveries. At the same time, recent evidence favours the use of different laboratory data to assess liver dama...There is a general consensus in re-interpreting the so-called liver function tests in the light of novel discoveries. At the same time, recent evidence favours the use of different laboratory data to assess liver damage, fibrosis or regenerative process, but this point is not always shared. Actually, balancing the need for diagnosis, prognostic evaluation and therapy response of liver disease with a good cost/benefit ratio is very difficult. New tests are probably not needed but the aim should be for better utilization of existing tests to contain the increasing cost of health care.展开更多
The compensation method aiming to reduce the irradiation on the user＇s body and to form a weak field area （a dark spot） in an antenna near region is considered. The results of the method development for the use in ...The compensation method aiming to reduce the irradiation on the user＇s body and to form a weak field area （a dark spot） in an antenna near region is considered. The results of the method development for the use in a narrow frequencies range are given. They show that under realistic conditions the compensation method allows reducing the irradiation power by a factor of 3-4 and more. The pattern changes are predictable and small, if the points of antennas placement are selected correctly. The dark spot necessity near the transmitter is not limited by mobile communication. A man often uses a low-power radio station, which is placed nearby in a vehicle, and it is necessary to protect from irradiation not only user but also other passengers. In the paper, it is shown that broadband field compensation can be achieved in various structures where the needed anti-phase fields are created either by identical antennas or by radiators located at equal distance from the compensation point, or by flat reflectors.展开更多
In order to reduce the gain of a receiving antenna in HPM power measurement,especially in lower frequency, a low gain dipole antenna of L band is designed.By theoretical analysis and numerical simulation,the optimized...In order to reduce the gain of a receiving antenna in HPM power measurement,especially in lower frequency, a low gain dipole antenna of L band is designed.By theoretical analysis and numerical simulation,the optimized results of the antenn are obtained:its central frequency is 1.75GHz,the variety of gain is less than 1.1dB in frequency band 1.70—1.80GHz,the estimated value of the power capacity of the antenna is 0.1MW,which can satisfy the demand of corresponding measurement.展开更多
Objective：To observe the clinical effect of deep insertion at Tianshu（ST 25）for colonic slow transit constipation（STC）.Methods：120 cases of STC patients were randomly divided,60 cases in a deep insertion group,3...Objective：To observe the clinical effect of deep insertion at Tianshu（ST 25）for colonic slow transit constipation（STC）.Methods：120 cases of STC patients were randomly divided,60 cases in a deep insertion group,30 cases in an electroacupuncture group and 30 cases in a medication group by 2：1：1 ratio.The deep insertion group was treated with deep insertion at Tianshu（ST 25）.The electroacupuncture group was treated with routine insertion at Tianshu（ST 25）.The medication group was treated with oral administration of Lactulose oral liquid.The first voluntary defecation time,and constipation scores before the treatment,four weeks after the treatment and relevant scores of clinical symptoms were assessed in the three groups of the patients.Results：The scores of the clinical symptoms in improvement of constipation were better in the deep insertion group than in the electroacupuncture group and medication group,with differences in statistical significance（P〈0.01）.The unsuccessful numbers in the improvement of defecation and abdominal pain were also better in the deep insertion group than in the other two groups,and better in instant effect in the deep insertion.Conclusion：The improvement of STC clinical symptoms was better by deep insertion at Tianshu（ST 25）than by medication and routine acupuncture method at Tianshu（ST 25）.展开更多
Recent progress harkens back to the old theme of immune memory, except this time in the area of innate immunity, to which traditional paradigm only prescribes a rudimentary first-line defense function with no memory. ...Recent progress harkens back to the old theme of immune memory, except this time in the area of innate immunity, to which traditional paradigm only prescribes a rudimentary first-line defense function with no memory. However, both in vitro and in vivo studies reveal that innate leukocytes may adopt distinct activation states such as priming, tolerance, and exhaustion, depending upon the history of prior challenges. The dynamic programming and potential memory of innate leukocytes may have far-reaching consequences in health and disease. This review aims to provide some salient features of innate programing and memory, patho-physiological consequences, underlying mechanisms, and current pressing issues.展开更多
文摘Idiopathic hypogonadotropic hypogonadism is a rare disease that is characterized by delayed/absent puberty and/or infertility due to an insufficient stimulation of an otherwise normal pituitary-gonadal axis by gonadotrophin-releasing hormone （GnRH） action. Because reduced or normal luteinizing hormone （LH）/follicle-stimulating hormone （FSH） levels may be observed in the affected patients, the term idiopathic central hypogonadism （ICH） appears to be more appropriate. This disease should be distinguished from central hypogonadism that is combined with other pituitary deficiencies. Isolated ICH has a complex pathogenesis and ~s fivefold more prevalent in males. ICH frequently appears in a sporadic form, but several familial cases have also been reported. This finding, in conjunction with the description of numerous pathogenetic gene variants and the generation of several knockout models, supports the existence of a strong genetic component. ICH may be associated with several morphogenetic abnormalities, which include osmic defects that, with ICH, constitute the cardinal manifestations of Kallmann syndrome （KS）. KS accounts for approximately 40% of the total ICH cases and has been generally considered to be a distinct subgroup. However, the description of several pedigrees, which include relatives who are affected either with isolated osmic defects, KS, or normo-osmic ICH （nlCH）, justifies the emerging idea that ICH is a complex genetic disease that is characterized by variable expressivity and penetrance. In this context, either multiple gene variants or environmental factors and epigenetic modifications may contribute to the variable disease manifestations. We review the genetic mechanisms that are presently known to be involved in ICH pathogenesis and provide a clinical overview of the 227 cases that have been collected by the collaborating centres of the Italian ICH Network.
文摘A new,low-cost RFID tag analog front-end compatible with ISO 14443A and ISO 14443B is presented. By substituting conventional multi-circle antenna with single-circle antenna, the package cost of the tag is greatly reduced. Based on this exasperate antenna performance,a new rectifier with high power conversion efficiency and low turn-on voltage is presented. The circuit is implemented in an SMIC 0.18μm EEPROM process. Measurement results show that with a 120kΩ load,the power conversion efficiency reaches as high as 36%. For a sinusoidal wave with magnitude of 0. 5V, the output DC voltage reaches IV,which is high enough for RFID tags. The read distance is as far as 22cm.
基金Supported by the Sectoral Operational Programme Human Resources Development(SOP HRD)Financed from the European Social Fundthe Romanian Government under the Contract Number POSDRU/89/1.5/S/63700
文摘The functional materials based on natural zeolite （clinoptilolite）, TiO2-zeolite and Ag-TiO2-zeolite have been successfully synthesized by solid-state reaction in fast-hydrothermal conditions. The obtained functional materials were investigated by X-ray diffraction （XRD）, FT-1R （Fourier transform infrared） spectroscopy, DRUV-VIS （diffuse reflectance ultraviolet-visible） spectroscopy, BET （Brunauer-Emmett-Teller） and SEM/EDX （scanning electron microscope/energy dispersive X-ray spectrometer） analyses. The XRD results indicated that the clinoptilolite structure has a good thermal stabilization after the fast-hydrothermal treatment. Also, the high specific surface area about 92.55 m^2.g^-1 was noticed for Ag-TiO2-zeolite functional material. The presence of dopants was evidenced from EDX spectra. The enhanced bactericidal activity of Ag-TiO2-zeolite catalyst is proved through damaging of Enterococcusfaecalis colonies under visible irradiation, at different material doses and irradiation times.
基金supported in part by the National Basic Research Program of China （2012CB315704） the National Natural Science Foundation of China（No.61275068） the Key Grant Project of Chinese Ministry of Education（No.313049）
文摘we demonstrate the adjustability of optimal input power(OIP) of the radio over fiber(RoF) link by proper link gain control in the central unit(CU) and remote antenna unit(RAU).The experiment results show that the reading and writing distance(RWD)of the radio frequency identification(RFID)service and the throughput of the WiFi service have a max increase of 3cm and 6.975Mbit/s respectively when the OIP value equals to output power of commercial products,compared with OIP value with 5-dBm right/left shift to the output power.
基金Supported by the National High Technology Research and Development Program of China("863"ProgramNo.2009AA011507)+2 种基金National Science and Technology Major Project of the Ministry of Science and Technology of China(No.2009ZX03007-003)National Natural Science Foundation of China(No.61101223)Ph.D.Programs Foundation of Ministry of Education of China(No.20110032120087 and No.20110032110029)
文摘To establish wireless channel suitable for the cabin environment, the power coverage was investigated with distributed antenna system and centralized antenna system based on the actual measurement of channel impulse response. The results indicated that the distributed antenna system has more uniform power coverage than the centralized antenna system. The average relative errors of receiving power of both antennas were calculated. The optimal position of the centralized antenna was obtained by Gaussian function refinement, making the system achieve a better transmission power with the same coverage effect, and providing a reference for antenna location in the future real communication in the cabin.
文摘The GF-3 satellite was successfully launched at 06：55 Beijing time on August10 using a LM-4C launch vehicle from the Taiyuan Satellite Launch Center.The launch was the 233rd flight of a LM family launch vehicle and the carrier rocket LM-4C was developed by the Shanghai Academy of Spaceflight Technology.
基金supported in part by the State Major Science and Technology Special Projects under Grant No. 2012ZX03004001the National Basic Research Program (973) of China under Grants No. 2012CB315801, No. 2011CB302901the Chinese Universities Scientific Fund under Grant No. 2012RC0306
文摘In thsssse cellular network, Relay Stations (RSs) help to improve the system performance; however, little work has been done considering the fairness of RSs. In this paper, we study the cooperative game approaches for scheduling in the wireless relay networks with two-virtual-antenna array mode. After defining the metric of relay channel capacity, we form a cooperative game for scheduling and present the interpretation of three different utilization objectives physically and mathematically. Then, a Nash Bargaining Solution (NBS) is utilized for resource allocation considering the traffic load fairness for relays. After proving the existence and uniqueness of NBS in Cooperative Game (CG-NBS), we are able to resolve the resource allocation problem in the cellular relay network by the relay selection and subcarrier assignment policy and the power allocation algorithm for both RSs and UEs. Simulation results reveal that the proposed CG-NBS scheme achieves better tradeoff between relay fairness and system throughput than the conventional Maximal Rate Optimization and Maximal Minimal Fairness methods.
文摘On August 2,a twin-segment solid rocket motor of the largest diameter,grain mass and thrust in China completed its ground test firing with success.The3 m solid motor was independently developed by the Academy of Aerospace Solid Propulsion Technology（AASPT）under CASC.
文摘There is a general consensus in re-interpreting the so-called liver function tests in the light of novel discoveries. At the same time, recent evidence favours the use of different laboratory data to assess liver damage, fibrosis or regenerative process, but this point is not always shared. Actually, balancing the need for diagnosis, prognostic evaluation and therapy response of liver disease with a good cost/benefit ratio is very difficult. New tests are probably not needed but the aim should be for better utilization of existing tests to contain the increasing cost of health care.
文摘The compensation method aiming to reduce the irradiation on the user＇s body and to form a weak field area （a dark spot） in an antenna near region is considered. The results of the method development for the use in a narrow frequencies range are given. They show that under realistic conditions the compensation method allows reducing the irradiation power by a factor of 3-4 and more. The pattern changes are predictable and small, if the points of antennas placement are selected correctly. The dark spot necessity near the transmitter is not limited by mobile communication. A man often uses a low-power radio station, which is placed nearby in a vehicle, and it is necessary to protect from irradiation not only user but also other passengers. In the paper, it is shown that broadband field compensation can be achieved in various structures where the needed anti-phase fields are created either by identical antennas or by radiators located at equal distance from the compensation point, or by flat reflectors.
文摘In order to reduce the gain of a receiving antenna in HPM power measurement,especially in lower frequency, a low gain dipole antenna of L band is designed.By theoretical analysis and numerical simulation,the optimized results of the antenn are obtained:its central frequency is 1.75GHz,the variety of gain is less than 1.1dB in frequency band 1.70—1.80GHz,the estimated value of the power capacity of the antenna is 0.1MW,which can satisfy the demand of corresponding measurement.
基金Special Project of TCM Science and Technology Study of State Administration of Chinese Medicine(06-07LQ07)
文摘Objective：To observe the clinical effect of deep insertion at Tianshu（ST 25）for colonic slow transit constipation（STC）.Methods：120 cases of STC patients were randomly divided,60 cases in a deep insertion group,30 cases in an electroacupuncture group and 30 cases in a medication group by 2：1：1 ratio.The deep insertion group was treated with deep insertion at Tianshu（ST 25）.The electroacupuncture group was treated with routine insertion at Tianshu（ST 25）.The medication group was treated with oral administration of Lactulose oral liquid.The first voluntary defecation time,and constipation scores before the treatment,four weeks after the treatment and relevant scores of clinical symptoms were assessed in the three groups of the patients.Results：The scores of the clinical symptoms in improvement of constipation were better in the deep insertion group than in the electroacupuncture group and medication group,with differences in statistical significance（P〈0.01）.The unsuccessful numbers in the improvement of defecation and abdominal pain were also better in the deep insertion group than in the other two groups,and better in instant effect in the deep insertion.Conclusion：The improvement of STC clinical symptoms was better by deep insertion at Tianshu（ST 25）than by medication and routine acupuncture method at Tianshu（ST 25）.
基金the support from the National Institute of Health grant HL 115835
文摘Recent progress harkens back to the old theme of immune memory, except this time in the area of innate immunity, to which traditional paradigm only prescribes a rudimentary first-line defense function with no memory. However, both in vitro and in vivo studies reveal that innate leukocytes may adopt distinct activation states such as priming, tolerance, and exhaustion, depending upon the history of prior challenges. The dynamic programming and potential memory of innate leukocytes may have far-reaching consequences in health and disease. This review aims to provide some salient features of innate programing and memory, patho-physiological consequences, underlying mechanisms, and current pressing issues.
