阮祥燕,首都医科大学附属北京妇产医院妇科内分泌科主任,首都医科大学妇产科学系副主任,首都医科大学教授、博士生导师,德国图宾根大学客座教授。美国哥伦比亚大学、德国图宾根大学、波恩大学等访问学者。中国人体健康科技促进会生育力...阮祥燕,首都医科大学附属北京妇产医院妇科内分泌科主任,首都医科大学妇产科学系副主任,首都医科大学教授、博士生导师,德国图宾根大学客座教授。美国哥伦比亚大学、德国图宾根大学、波恩大学等访问学者。中国人体健康科技促进会生育力保护与保存专业委员会主委、全国卵巢保护与抗衰促进工程项目专家委员会主委、北京妇产学会内分泌分会主委、中华医学会妇产科分会绝经学组委员及妇科内分泌学组委员、国际妇科内分泌学会与国际绝经学会执行委员会委员、国际妇科内分泌学会中国妇科内分泌学分会主席。卵巢组织冻存库负责人,国际生殖力保护中心负责人,中华人民共和国国务院政府特殊津贴专家。主持国家自然科学基金等项目50余项;发表论文论著近300篇,S C I论文60篇,出版论著5部、科普书1部(2版)。展开更多
Objective: To determine whether endometrial expression of endothelial nitric oxide synthase (eNOS) or inducible NOS (iNOS) protein in women with endometriosis-associated infertility is different from that in the ferti...Objective: To determine whether endometrial expression of endothelial nitric oxide synthase (eNOS) or inducible NOS (iNOS) protein in women with endometriosis-associated infertility is different from that in the fertile controls, whether GnRH agonist (GnRH- a) regulates the endometrial expression of NOS in women with endometriosis- associated infertility, and whether there is a correlation between serum E2 or P levels, and the endometrial expression of eNOS or iNOS. Design: Prospective controlled study. Setting: University hospital for reproductive medicine and gynecologic endocrinology. Patient(s): Thirty patients with endometriosis-associated infertility and 19 patients with carcinoma in situ of the cervix. Intervention(s): Endometrial biopsy specimens and blood samples. Main Outcome Measure(s): Endometrial eNOS and iNOS protein relative levels and serum concentrations of E2 or P. Result(s): By Western blot analysis, iNOS was not detected, and a unique menstrual cycle-dependent expression of eNOS was observed. Eutopic endometrium in women with endometriosis-associated infertility before GnRH-a treatment showed higher levels of eNOS than that of the control group. After 3 months of GnRH-a therapy, eNOS levels in the endometrium were reduced. In addition, a significant positive correlation was found between serum E2 or P concentrations, and the endometrial expression of eNOS. Conclusion(s): The GnRH-a treatment attenuated the endometrial expression of eNOS in women with endometriosis-associated infertility. Endogenous ovarian steroids influence endometrial eNOS expression.展开更多
文摘阮祥燕,首都医科大学附属北京妇产医院妇科内分泌科主任,首都医科大学妇产科学系副主任,首都医科大学教授、博士生导师,德国图宾根大学客座教授。美国哥伦比亚大学、德国图宾根大学、波恩大学等访问学者。中国人体健康科技促进会生育力保护与保存专业委员会主委、全国卵巢保护与抗衰促进工程项目专家委员会主委、北京妇产学会内分泌分会主委、中华医学会妇产科分会绝经学组委员及妇科内分泌学组委员、国际妇科内分泌学会与国际绝经学会执行委员会委员、国际妇科内分泌学会中国妇科内分泌学分会主席。卵巢组织冻存库负责人,国际生殖力保护中心负责人,中华人民共和国国务院政府特殊津贴专家。主持国家自然科学基金等项目50余项;发表论文论著近300篇,S C I论文60篇,出版论著5部、科普书1部(2版)。
文摘Objective: To determine whether endometrial expression of endothelial nitric oxide synthase (eNOS) or inducible NOS (iNOS) protein in women with endometriosis-associated infertility is different from that in the fertile controls, whether GnRH agonist (GnRH- a) regulates the endometrial expression of NOS in women with endometriosis- associated infertility, and whether there is a correlation between serum E2 or P levels, and the endometrial expression of eNOS or iNOS. Design: Prospective controlled study. Setting: University hospital for reproductive medicine and gynecologic endocrinology. Patient(s): Thirty patients with endometriosis-associated infertility and 19 patients with carcinoma in situ of the cervix. Intervention(s): Endometrial biopsy specimens and blood samples. Main Outcome Measure(s): Endometrial eNOS and iNOS protein relative levels and serum concentrations of E2 or P. Result(s): By Western blot analysis, iNOS was not detected, and a unique menstrual cycle-dependent expression of eNOS was observed. Eutopic endometrium in women with endometriosis-associated infertility before GnRH-a treatment showed higher levels of eNOS than that of the control group. After 3 months of GnRH-a therapy, eNOS levels in the endometrium were reduced. In addition, a significant positive correlation was found between serum E2 or P concentrations, and the endometrial expression of eNOS. Conclusion(s): The GnRH-a treatment attenuated the endometrial expression of eNOS in women with endometriosis-associated infertility. Endogenous ovarian steroids influence endometrial eNOS expression.
