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补肾固胎方联合黄体酮注射液治疗肾虚型早期先兆流产疗效及对妊娠激素水平和Th1/Th2细胞因子的影响 被引量:3
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作者 戴凌虹 孙云 颜晓钏 《中华中医药学刊》 CAS 北大核心 2024年第3期221-224,共4页
目的 观察补肾固胎方联合黄体酮注射液治疗肾虚型早期先兆流产疗效及对妊娠激素水平和Th1/Th2细胞因子的影响。方法 采用随机数字表法将符合入选标准的120例肾虚型早期先兆流产患者分为观察组和对照组。对照组予黄体酮注射液治疗,观察... 目的 观察补肾固胎方联合黄体酮注射液治疗肾虚型早期先兆流产疗效及对妊娠激素水平和Th1/Th2细胞因子的影响。方法 采用随机数字表法将符合入选标准的120例肾虚型早期先兆流产患者分为观察组和对照组。对照组予黄体酮注射液治疗,观察组同联合补肾固胎方治疗。连续治疗2周后,比较两组中医证候积分(妊娠期阴道流血、小腹坠胀或疼痛、腰酸痛、膝关节酸软)、妊娠激素水平[雌二醇(Estradiol, E_(2))、人绒毛膜促性腺激素(Human chorionic gonadotropin, β-HCG)、孕酮(Progesterone, P)]、Th1/Th2细胞因子[白细胞介素2(interleukin-2,IL-2)、白细胞介素4(interleukin-4,IL-4)、γ干扰素(Interferon-γ,INF-γ)]改善情况,统计两组治疗总有效率、妊娠结局及不良反应发生率。结果 两组治疗后妊娠期阴道流血、小腹坠胀或疼痛、腰酸痛、膝关节酸软积分,IL-2、INF-γ水平均低于治疗前(P<0.05),且观察组治疗后以上中医证候积分和IL-2、INF-γ水平均低于对照组(P<0.05);两组治疗后IL-4水平均高于治疗前(P<0.05),且观察组治疗后IL-4水平高于对照组(P<0.05);观察组总有效率为(91.7%,55/60),高于对照组(75.0%,45/60)(P<0.05);观察组足月分娩率为(85.0%,51/60),高于对照组(56.7%,34/60)(P<0.05);观察组不良反应发生率为3.3%,低于对照组(25.0%)(P<0.05)。结论 补肾固胎方联合黄体酮注射液能够有效调节肾虚型早期先兆流产患者妊娠激素水平和Th1/Th2细胞因子水平,纠正免疫功能紊乱,降低患者流产率,提高足月妊娠率,改善妊娠结局。 展开更多
关键词 早期先兆流产 肾虚型 补肾固胎方 黄体酮注射液 妊娠激素水平 TH1/TH2细胞因子
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保胎无忧胶囊联合地屈孕酮对先兆性流产患者妊娠激素水平的影响 被引量:1
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作者 廖水新 《海峡药学》 2021年第5期164-166,共3页
目的探讨保胎无忧胶囊、地屈孕酮联合治疗对先兆性流产患者妊娠激素水平的影响。方法随机数字表法将104先兆性流产患者分为对照组、联合组,每组各52例。对照组采用地屈孕酮片治疗,联合组采用保胎无忧胶囊、地屈孕酮联合治疗,比较两组疼... 目的探讨保胎无忧胶囊、地屈孕酮联合治疗对先兆性流产患者妊娠激素水平的影响。方法随机数字表法将104先兆性流产患者分为对照组、联合组,每组各52例。对照组采用地屈孕酮片治疗,联合组采用保胎无忧胶囊、地屈孕酮联合治疗,比较两组疼痛视觉模拟评分法(VAS评分)、保胎成功率、不良反应、妊娠激素水平变化情况。结果联合组保胎成功率、各项激素指标水平明显高于对照组,且联合组不良反应、流产率、VAS评分均低于对照组,差异均具有统计学意义(P<0.05)。结论对先兆性流产患者给予保胎无忧胶囊、地屈孕酮联合治疗可提高妊娠激素水平,减轻患者腹痛症状,提高保胎成功率,不良反应少,疗效安全可靠。 展开更多
关键词 妊娠激素水平 保胎无忧胶囊 先兆性流产 地屈孕酮 联合治疗
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Second-trimester maternal β-human chorionic gonadotropin level associated with subsequent development of pregnancy-induced hypertension 被引量:2
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作者 Tang Longying Chen Qizhen +3 位作者 Zuo Wanxin Sun Tingwei Wang Yianshu Jin Hua 《Journal of Medical Colleges of PLA(China)》 CAS 2010年第5期293-297,共5页
Objective:To determine whether maternal β-human chorionic gonadotropin(β-hCG) level in second-trimester may be associated with subsequent development of pregnancy-induced hypertension(PIH).Methods:Seven hundred and ... Objective:To determine whether maternal β-human chorionic gonadotropin(β-hCG) level in second-trimester may be associated with subsequent development of pregnancy-induced hypertension(PIH).Methods:Seven hundred and sixty-two women in mid-trimester were to have maternal urine β-hCG standardized concentrations and maternal serum β-hCG measurements.Their case histories were recorded and reviewed from mid-trimester to delivery.The relation was observed between maternal urine,serum markers and subsequent development of PIH.Results:Among 762 women,504 cases were normal pregnancies,42 cases had PIH,94 cases had premature rupture of membrane (PROM),69 cases had preterm delivery (PD),53 other cases were excluded by various reasons.The levels of maternal urine,serum β-hCG in PIH were (61.75±9.78) IU/L and (304.56±54.17) ng/mg respectively,which were higher significantly than normal pregnancy group ([20.65±7.61] IU/L and [146.34±47.81] ng/mg,P<0.05).When maternal serum,urine β-hCG levels ≥2 MOM(multiple of mean),the incidences of developing PIH were increased significantly as compared with those of β-hCG <2 MOM women.The incidence of PIH increased from 5.1% in pregnancies with urine β-hCG ≥2 MOM to 11.7% in cases with urine β-hCG ≥4 MOM.Conclusion:The elevation of maternal mid-trimester urine,serum β-hCG levels is not only an early signal for dysfunction of placenta but also a dangerous signal for development of PIH.Second-trimester maternal urine β-hCG measurement proves to be superior to serum marker in clinical prediction. 展开更多
关键词 Second-trimester β-human chorionic gonadotropin Pregnancy-induced hypertension PLACENTA
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