By the chemical dynamics principle, the stability of the Zishen xuekang tablet was observed. The initial uniform rate method was used to observe the content change of the sample, the content of Tanshione IIA was deter...By the chemical dynamics principle, the stability of the Zishen xuekang tablet was observed. The initial uniform rate method was used to observe the content change of the sample, the content of Tanshione IIA was determined by high pressure liquid chromatogram method and predicted the shelf life of Zishen xuekang tablet under the room temperature. Within the range of temperature between 26～95℃,the contents of Tanshione IIA in sample were 188±14～243±10 μg·g -1 , the time that 90% content of sample decomposed is 0.93 year ( t 0.9 = 0.93 a). The shelf life under the room temperature is about one year, which can be satisfied to the need of the medicines storage.展开更多
文摘目的探讨牛膝多糖的安全性及其制剂的稳定性.方法通过毒性作用实验和半数致死量(LD50)的测定确定其安全性.以经典恒温实验法考察牛膝多糖制剂(牛膝合剂)的稳定性.结果牛膝多糖对小鼠的LD50为18.87～13.27 g·kg-1,其制剂的有效期限为2.2 a.结论该实验测得的半数致死量数据可靠,牛膝合剂的有效期可确定为2 a.
文摘By the chemical dynamics principle, the stability of the Zishen xuekang tablet was observed. The initial uniform rate method was used to observe the content change of the sample, the content of Tanshione IIA was determined by high pressure liquid chromatogram method and predicted the shelf life of Zishen xuekang tablet under the room temperature. Within the range of temperature between 26～95℃,the contents of Tanshione IIA in sample were 188±14～243±10 μg·g -1 , the time that 90% content of sample decomposed is 0.93 year ( t 0.9 = 0.93 a). The shelf life under the room temperature is about one year, which can be satisfied to the need of the medicines storage.
