Using capillary zone electrophoresis,the enantiomers resolution of 13 pharmaceuticals including non-amide,primary amine,the secondary amine and the tertiary amine was studied with highly sulfated – α(β,γ)-cyclodex...Using capillary zone electrophoresis,the enantiomers resolution of 13 pharmaceuticals including non-amide,primary amine,the secondary amine and the tertiary amine was studied with highly sulfated – α(β,γ)-cyclodextrins(HS-α(β,γ)-CD) as chiral selector,It was found a good resolution effect for the amide chiral pharmaceuticals,especially for tertiary amine.Through the primary analysis of chiral resolution mechanism,it was believed there be the static gravitational action in addition to space matches and hydrogen bonding between highly sulfated cyclodextrins and the amine drugs.With mobility shift method,Determination of binding constants between chlorpheniramine,hydrochloride isoprenaline,naphthylethylamine and HS-β-CD showed that the binding constant order of chlorpheniramine > hydrochloride isoprenaline > naphthylethylamine,and that highly sulfonated cyclodextrins and the tertiary amine the strongest action force.展开更多
文摘Using capillary zone electrophoresis,the enantiomers resolution of 13 pharmaceuticals including non-amide,primary amine,the secondary amine and the tertiary amine was studied with highly sulfated – α(β,γ)-cyclodextrins(HS-α(β,γ)-CD) as chiral selector,It was found a good resolution effect for the amide chiral pharmaceuticals,especially for tertiary amine.Through the primary analysis of chiral resolution mechanism,it was believed there be the static gravitational action in addition to space matches and hydrogen bonding between highly sulfated cyclodextrins and the amine drugs.With mobility shift method,Determination of binding constants between chlorpheniramine,hydrochloride isoprenaline,naphthylethylamine and HS-β-CD showed that the binding constant order of chlorpheniramine > hydrochloride isoprenaline > naphthylethylamine,and that highly sulfonated cyclodextrins and the tertiary amine the strongest action force.
