以L aC l3.7H2O替代传统液体无机酸为催化剂,以合成异丁酸正丁酯为探针反应考察催化酯化反应的优化条件,并在此条件下合成了多种异丁酸酯,比较了不同催化剂对催化合成异丁酸正丁酯的影响。实验结果表明,L aC l3.7H2O对酯化反应具有良好...以L aC l3.7H2O替代传统液体无机酸为催化剂,以合成异丁酸正丁酯为探针反应考察催化酯化反应的优化条件,并在此条件下合成了多种异丁酸酯,比较了不同催化剂对催化合成异丁酸正丁酯的影响。实验结果表明,L aC l3.7H2O对酯化反应具有良好的催化活性,并能避免液体无机酸催化剂所引起的弊端,异丁酸正丁酯的酯化率可达96.5%。且催化剂易回收,反应后处理简单,无废酸排放,是一种环境友好型催化剂。展开更多
To study the rheological properties of sucrose acetate isobutyrate(SAIB) in situ gel and the influencing factors.Measurements of shear stress and viscosity were carried out at different shear rate.The rheological prop...To study the rheological properties of sucrose acetate isobutyrate(SAIB) in situ gel and the influencing factors.Measurements of shear stress and viscosity were carried out at different shear rate.The rheological properties of SAIB solution were similar to those of Newtonian fluid.The factors such as the type of solvent,concentration,additive,drug and temperature had effect on the rheological properties.Ethanol was a suitable solvent compared with ethyl lactate and N-methylpyrrolidone(NMP).The solution viscosity of SAIB was reduced from 1.29 to 0.11 Pa·s with only increasing the content of ethanol from 10% to 20%.Polylactic acid(PLA) and risperidone could increase the intermolecular force and viscosity.However,adding 10%(w/w) PLA,the initial release of risperidone was reduced from 20.2% to 3.5%.The solution viscosity reduced significantly by stepping up the temperature.The results obtained support the using of SAIB is satisfactorily injectable in situ gel formulation.展开更多
文摘以L aC l3.7H2O替代传统液体无机酸为催化剂,以合成异丁酸正丁酯为探针反应考察催化酯化反应的优化条件,并在此条件下合成了多种异丁酸酯,比较了不同催化剂对催化合成异丁酸正丁酯的影响。实验结果表明,L aC l3.7H2O对酯化反应具有良好的催化活性,并能避免液体无机酸催化剂所引起的弊端,异丁酸正丁酯的酯化率可达96.5%。且催化剂易回收,反应后处理简单,无废酸排放,是一种环境友好型催化剂。
文摘To study the rheological properties of sucrose acetate isobutyrate(SAIB) in situ gel and the influencing factors.Measurements of shear stress and viscosity were carried out at different shear rate.The rheological properties of SAIB solution were similar to those of Newtonian fluid.The factors such as the type of solvent,concentration,additive,drug and temperature had effect on the rheological properties.Ethanol was a suitable solvent compared with ethyl lactate and N-methylpyrrolidone(NMP).The solution viscosity of SAIB was reduced from 1.29 to 0.11 Pa·s with only increasing the content of ethanol from 10% to 20%.Polylactic acid(PLA) and risperidone could increase the intermolecular force and viscosity.However,adding 10%(w/w) PLA,the initial release of risperidone was reduced from 20.2% to 3.5%.The solution viscosity reduced significantly by stepping up the temperature.The results obtained support the using of SAIB is satisfactorily injectable in situ gel formulation.
