This article focuses on the study of stability of motion of the phase systems described by differential equations whose right-hand sides are periodic in the angular coordinate. The article deals with the mathematical ...This article focuses on the study of stability of motion of the phase systems described by differential equations whose right-hand sides are periodic in the angular coordinate. The article deals with the mathematical model which has been investigated for stability ＂in the large＂ using the second Lyapunov method. Based on the theoretical results obtained in the work,the computational experiments on concrete examples of electric power systems, which showedthe sufficient efficacy of the proposed method for the studied phase system, were conducted.展开更多
Equilibrium function in the cerebellum （vestibulo-cerebellar system） can deteriorate under the influence of alcohol. In the Romberg posture, the center of gravity, which was measured every 50 ms by stabilometry, app...Equilibrium function in the cerebellum （vestibulo-cerebellar system） can deteriorate under the influence of alcohol. In the Romberg posture, the center of gravity, which was measured every 50 ms by stabilometry, appeared to shift with alcohol ingestion. In the previous study, a locus in the center of gravity （stabilogram） was converted to values of statistical indices such as area of sway, total locus length, sparse density, and locus length per unit area, although these indices could not always distinguish between the stabilograms sampled from seven healthy young males in sober and intoxicated states. This measurement was made with an AMTI force plate. In this study, ＂translation error＂ was estimated in a d-dimensional embedding space in order to compare stabilograms recorded before and after the ingestion of doubly diluted brandy in 30 s （1 ≤ d ≤ 10）. The authors succeeded in validating stochastic differential equations as a mathematical model of the body sway. Although the postural control system shows different patterns in the lateral and anterior-posterior directions, the randomness in the model was preserved after alcohol intake and significantly increased in the medial/lateral direction. Visual information referred by the postural conlrol system when standing might be interfered by the effects of intoxication, which was regarded as disturbance. The possibility of detecting alcohol-ingestion-induced reduction of the equilibrium function and its recovery process are also suggested in this paper. This method is considered to be useful to diagnose the disorders of the vestibulo-cerebellar system.展开更多
This paper introduces the main methods and steps of modeling principle by ordinary differential equations, and is used to explore the differential equation model to solve some practical problems, some features of the ...This paper introduces the main methods and steps of modeling principle by ordinary differential equations, and is used to explore the differential equation model to solve some practical problems, some features of the related problems. With the development of science and technology and production practice, differential equation is more closely connected with other subjects, and a mathematical model for some practical problems of good.展开更多
Mathematics is very important for the engineering and scientist but to make understand the mathematics is very difficult if without proper tools and suitable measurement. A numerical method is one of the algorithms wh...Mathematics is very important for the engineering and scientist but to make understand the mathematics is very difficult if without proper tools and suitable measurement. A numerical method is one of the algorithms which involved with computer programming. In this paper, Scilab is used to carter the problems related the mathematical models such as Matrices, operation with ODE＇s and solving the Integration.展开更多
Autoimmune diseases are generated through irregular immune response of the human body. Psoriasis is one type of autoimmune chronic skin diseases that is differentiated by T-Cells mediated hyper-proliferation of epider...Autoimmune diseases are generated through irregular immune response of the human body. Psoriasis is one type of autoimmune chronic skin diseases that is differentiated by T-Cells mediated hyper-proliferation of epidermal Keratinocytes. Dendritic Cells and CD8＋ T-Cells have a significant role for the occurrence of this disease. In this paper, the authors have developed a mathematical model of Psoriasis involving CD4＋ T-Cells, Dendritic Ceils, CD8＋ T-Cells and Keratinocyte cell populations using the fractional differential equations with the effect of Cytokine release to observe the impact of memory on the cell-biological system. Using fractional calculus, the authors try to explore the suppressed memory, associated with the cell-biological system and to locate the position of Keratinocyte cell population as fractional derivative possess non-local property. Thus, the dynamics of Psoriasis can be predicted in a better way using fractional differential equations rather than its corresponding integer order model. Finally, the authors introduce drug into the system to obstruct the interaction between CD4＋ T-Cells and Keratinocytes to restrict the disease Psoriasis. The authors derive the Euler-Lagrange conditions for the optimality made through Matlab by developing iterative of the drug induced system. Numerical simulations are schemes.展开更多
Dynamical characteristics of an integrodifferential modelling competitive sys-tem with diffusion are investigated.In particular,we derive sufficient conditions for the permanence of species,existence of an attracting ...Dynamical characteristics of an integrodifferential modelling competitive sys-tem with diffusion are investigated.In particular,we derive sufficient conditions for the permanence of species,existence of an attracting periodic solution to the periodic system.The results of Wang Ke in 1994 and 1998 are improved and extended.展开更多
The max-min approach is applied to mathematical models of some nonlinear oscillations.The models are regarding to three different forms that are governed by nonlinear ordinary differential equations.In this context,th...The max-min approach is applied to mathematical models of some nonlinear oscillations.The models are regarding to three different forms that are governed by nonlinear ordinary differential equations.In this context,the strongly nonlinear Duffing oscillator with third,fifth,and seventh powers of the amplitude,the pendulum attached to a rotating rigid frame and the cubic Duffing oscillator with discontinuity are taken into consideration.The obtained results via the approach are compared with ones achieved utilizing other techniques.The results indicate that the approach has a good agreement with other well-known methods.He's max-min approach is a promising technique and can be successfully exerted to a lot of practical engineering and physical problems.展开更多
The bounded and smooth solitary wave solutions of 10 nonlinear evolution equations with a positive fractional power term of dependent variable are successfully obtained by homogeneous balance principle and with the ai...The bounded and smooth solitary wave solutions of 10 nonlinear evolution equations with a positive fractional power term of dependent variable are successfully obtained by homogeneous balance principle and with the aid of sub-ODEs that admits a solution of sech-power or tanh-power type.In the special cases that the fractional power equals to 1 and 2,the solitary wave solutions of more than 10 important model equations arisen from mathematical physics are easily rediscovered.展开更多
Ever since HIV was first diagnosed in human, a great number of scientific works have been undertaken to explore the biological mechanisms involved in the infection and progression of the disease. This paper deals with...Ever since HIV was first diagnosed in human, a great number of scientific works have been undertaken to explore the biological mechanisms involved in the infection and progression of the disease. This paper deals with stability and bifurcation analyses of mathematical model that represents the dynamics of HIV infection of thymus. The existence and stability of the equilibria are investigated. The model is described by a system of delay differential equations with logistic growth term, cure rate and discrete type of time delay. Choosing the time delay as a bifurcation parameter, the analysis is mainly focused on the Hopf bifurcation problem to predict the existence of a limit cycle bifurcating from the infected steady state.Further, using center manifold theory and normal form method we derive explicit formulae to determine the stability and direction of the limit cycles. Moreover the mitosis rate r also plays a vital role in the model, so we fix it as second bifurcation parameter in the incidence of viral infection. Our analysis shows that, while both the bifurcation parameters can destabilize the equilibrium E＊ and cause limit cycles. Numerical simulations are performed to investigate the qualitative behaviors of the inherent model.展开更多
This paper presents an alternative representation of a system of differential equations qualitatively showing the behavior of the biological rhythm of a crayfish during their transition from juvenile to adult stages. ...This paper presents an alternative representation of a system of differential equations qualitatively showing the behavior of the biological rhythm of a crayfish during their transition from juvenile to adult stages. The model focuses on the interaction of four cellular oscillators coupled by diffusion of a hormone, a parameter μ is used to simu- late the quality of communication among the oscillators, in biological terms, it mea- sures developmental maturity of the crayfish. Since some quorum-sensing mechanism is assumed to be responsible for the synchronization of the biological oscillators, it is nat- ural to investigate the possibility that the underlying diffusion process is not standard, i.e. it may be a so-called anomalous diffusion. In this case, it is well understood that diffusion equations with fractional derivatives describe these processes in a more realis- tic way. The alternative formulation of these equations contains fractional operators of Liouville-Caputo and Caputo-Fabrizio type. The numerical simulations of the equations reflect synchronization of ultradian rhythms leading to a circadian rhythm. The classical behavior is recovered when the order of the fractional derivative is V = 1. We discuss possible biological implications.展开更多
In modern days, biodegradable polymeric matrix used as the kingpin of local drug delivery system is in the center of attention. This work is concentrated on the formulation of mathematical model elucidating degradatio...In modern days, biodegradable polymeric matrix used as the kingpin of local drug delivery system is in the center of attention. This work is concentrated on the formulation of mathematical model elucidating degradation of drug-loaded polymeric matrix followed by drug release to the adjacent biological tissues. Polymeric degradation is penciled with mass conservation equations. Drug release phenomenon is modeled by considering solubilization dynamics of drug particles, diffusion of the solubilized drug through polymeric matrix along with reversible dissociation/recrystallization process. In the tissue phase, reversible dissociation/association along with internalization processes of drug are taken into account. For this, a two-phase spatio-temporal model is postu- lated, which has ensued to a system of partial differential equations. They are solved analytically with appropriate choice of initial, interface and boundary conditions. In order to reflect the potency of the advocated model, the simulated results are analogized with corresponding experimental data and found laudable agreement so as to validate the applicability of the model considered. This model seems to foster the delicacy of the mantle enacted by important drug kinetic parameters such as diffusion coefficients, mass transfer coefficients, particle binding and internalization parameters, which is illustrated through local sensitivity analysis.展开更多
In this paper, we extensively studied a mathematical model of biology. It helps us to understand the dynamical procedure of population changes in biological population model and provides valuable predictions. In this ...In this paper, we extensively studied a mathematical model of biology. It helps us to understand the dynamical procedure of population changes in biological population model and provides valuable predictions. In this model, we establish a variety of exact solutions. To study the exact solutions, we used a fractional complex transform to convert the particular partial differential equation of fractional order into corresponding partial differential equation and modified exp-function method is implemented to investigate the nonlinear equation. Graphical demonstrations along with the numerical data reinforce the efficacy of the used procedure. The specified idea is very effective, unfailing, well-organized and pragmatic for fractional PDEs and could be protracted to further physical happenings.展开更多
In this paper, we apply the method of directly defining the inverse mapping introduced by Liao and Zhao [On the method of directly defining inverse mapping for nonlinear differential equations, Numer. Algorithms 72（4...In this paper, we apply the method of directly defining the inverse mapping introduced by Liao and Zhao [On the method of directly defining inverse mapping for nonlinear differential equations, Numer. Algorithms 72（4） （2016） 989-1020] to the problem of prostate cancer immunotherapy. We extend this method in two directions： first, we apply the method to a system of nonlinear ordinary differential equation, and second, we propose a new technique for finding the base functions in the considered algorithm.展开更多
Mathematical models and computer simulations are useful experimental tools for building and testing theories. Many mathematical models in biology can be formulated by a nonlinear system of ordinary differential equati...Mathematical models and computer simulations are useful experimental tools for building and testing theories. Many mathematical models in biology can be formulated by a nonlinear system of ordinary differential equations. This work deals with the numerical solution of the hantavirus infection model, the human immunodeficiency virus （HIV） infection model of CD4^＋T cells and the susceptible-infected-removed （SIR） epidemic model using a new reliable algorithm based on shifted Boubaker Lagrangian （SBL） method. This method reduces the solution of such system to a system of linear or non- linear algebraic equations which are solved using the Newton iteration method. The obtained results of the proposed method show highly accurate and valid for an arbitrary finite interval. Also, those are compared with fourth-order Runge-Kutta （RK4） method and with the solutions obtained by some other methods in the literature.展开更多
A modified mathematical model of hepatitis C viral dynamics has been presented in this paper, which is described by four coupled ordinary differential equations. The aim of this paper is to perform global stability an...A modified mathematical model of hepatitis C viral dynamics has been presented in this paper, which is described by four coupled ordinary differential equations. The aim of this paper is to perform global stability analysis using geometric approach to stability, based on the higher-order generalization of Bendixson＇s criterion. The result is also supported numerically. An important epidemiological issue of eradicating hepatitis C virus has been addressed through the global stability analysis.展开更多
文摘This article focuses on the study of stability of motion of the phase systems described by differential equations whose right-hand sides are periodic in the angular coordinate. The article deals with the mathematical model which has been investigated for stability ＂in the large＂ using the second Lyapunov method. Based on the theoretical results obtained in the work,the computational experiments on concrete examples of electric power systems, which showedthe sufficient efficacy of the proposed method for the studied phase system, were conducted.
文摘Equilibrium function in the cerebellum （vestibulo-cerebellar system） can deteriorate under the influence of alcohol. In the Romberg posture, the center of gravity, which was measured every 50 ms by stabilometry, appeared to shift with alcohol ingestion. In the previous study, a locus in the center of gravity （stabilogram） was converted to values of statistical indices such as area of sway, total locus length, sparse density, and locus length per unit area, although these indices could not always distinguish between the stabilograms sampled from seven healthy young males in sober and intoxicated states. This measurement was made with an AMTI force plate. In this study, ＂translation error＂ was estimated in a d-dimensional embedding space in order to compare stabilograms recorded before and after the ingestion of doubly diluted brandy in 30 s （1 ≤ d ≤ 10）. The authors succeeded in validating stochastic differential equations as a mathematical model of the body sway. Although the postural control system shows different patterns in the lateral and anterior-posterior directions, the randomness in the model was preserved after alcohol intake and significantly increased in the medial/lateral direction. Visual information referred by the postural conlrol system when standing might be interfered by the effects of intoxication, which was regarded as disturbance. The possibility of detecting alcohol-ingestion-induced reduction of the equilibrium function and its recovery process are also suggested in this paper. This method is considered to be useful to diagnose the disorders of the vestibulo-cerebellar system.
文摘This paper introduces the main methods and steps of modeling principle by ordinary differential equations, and is used to explore the differential equation model to solve some practical problems, some features of the related problems. With the development of science and technology and production practice, differential equation is more closely connected with other subjects, and a mathematical model for some practical problems of good.
文摘Mathematics is very important for the engineering and scientist but to make understand the mathematics is very difficult if without proper tools and suitable measurement. A numerical method is one of the algorithms which involved with computer programming. In this paper, Scilab is used to carter the problems related the mathematical models such as Matrices, operation with ODE＇s and solving the Integration.
基金supported by the Council of Scientific and Industrial Research,Government of India under Grant No.38(1320)/12/EMR-II
文摘Autoimmune diseases are generated through irregular immune response of the human body. Psoriasis is one type of autoimmune chronic skin diseases that is differentiated by T-Cells mediated hyper-proliferation of epidermal Keratinocytes. Dendritic Cells and CD8＋ T-Cells have a significant role for the occurrence of this disease. In this paper, the authors have developed a mathematical model of Psoriasis involving CD4＋ T-Cells, Dendritic Ceils, CD8＋ T-Cells and Keratinocyte cell populations using the fractional differential equations with the effect of Cytokine release to observe the impact of memory on the cell-biological system. Using fractional calculus, the authors try to explore the suppressed memory, associated with the cell-biological system and to locate the position of Keratinocyte cell population as fractional derivative possess non-local property. Thus, the dynamics of Psoriasis can be predicted in a better way using fractional differential equations rather than its corresponding integer order model. Finally, the authors introduce drug into the system to obstruct the interaction between CD4＋ T-Cells and Keratinocytes to restrict the disease Psoriasis. The authors derive the Euler-Lagrange conditions for the optimality made through Matlab by developing iterative of the drug induced system. Numerical simulations are schemes.
基金This research is supported by the National Natural Science Foundation of China.
文摘Dynamical characteristics of an integrodifferential modelling competitive sys-tem with diffusion are investigated.In particular,we derive sufficient conditions for the permanence of species,existence of an attracting periodic solution to the periodic system.The results of Wang Ke in 1994 and 1998 are improved and extended.
文摘The max-min approach is applied to mathematical models of some nonlinear oscillations.The models are regarding to three different forms that are governed by nonlinear ordinary differential equations.In this context,the strongly nonlinear Duffing oscillator with third,fifth,and seventh powers of the amplitude,the pendulum attached to a rotating rigid frame and the cubic Duffing oscillator with discontinuity are taken into consideration.The obtained results via the approach are compared with ones achieved utilizing other techniques.The results indicate that the approach has a good agreement with other well-known methods.He's max-min approach is a promising technique and can be successfully exerted to a lot of practical engineering and physical problems.
基金Supported by the Natural Science Foundation of Education Department of Henan Province of China under Grant No.2011B110013
文摘The bounded and smooth solitary wave solutions of 10 nonlinear evolution equations with a positive fractional power term of dependent variable are successfully obtained by homogeneous balance principle and with the aid of sub-ODEs that admits a solution of sech-power or tanh-power type.In the special cases that the fractional power equals to 1 and 2,the solitary wave solutions of more than 10 important model equations arisen from mathematical physics are easily rediscovered.
文摘Ever since HIV was first diagnosed in human, a great number of scientific works have been undertaken to explore the biological mechanisms involved in the infection and progression of the disease. This paper deals with stability and bifurcation analyses of mathematical model that represents the dynamics of HIV infection of thymus. The existence and stability of the equilibria are investigated. The model is described by a system of delay differential equations with logistic growth term, cure rate and discrete type of time delay. Choosing the time delay as a bifurcation parameter, the analysis is mainly focused on the Hopf bifurcation problem to predict the existence of a limit cycle bifurcating from the infected steady state.Further, using center manifold theory and normal form method we derive explicit formulae to determine the stability and direction of the limit cycles. Moreover the mitosis rate r also plays a vital role in the model, so we fix it as second bifurcation parameter in the incidence of viral infection. Our analysis shows that, while both the bifurcation parameters can destabilize the equilibrium E＊ and cause limit cycles. Numerical simulations are performed to investigate the qualitative behaviors of the inherent model.
文摘This paper presents an alternative representation of a system of differential equations qualitatively showing the behavior of the biological rhythm of a crayfish during their transition from juvenile to adult stages. The model focuses on the interaction of four cellular oscillators coupled by diffusion of a hormone, a parameter μ is used to simu- late the quality of communication among the oscillators, in biological terms, it mea- sures developmental maturity of the crayfish. Since some quorum-sensing mechanism is assumed to be responsible for the synchronization of the biological oscillators, it is nat- ural to investigate the possibility that the underlying diffusion process is not standard, i.e. it may be a so-called anomalous diffusion. In this case, it is well understood that diffusion equations with fractional derivatives describe these processes in a more realis- tic way. The alternative formulation of these equations contains fractional operators of Liouville-Caputo and Caputo-Fabrizio type. The numerical simulations of the equations reflect synchronization of ultradian rhythms leading to a circadian rhythm. The classical behavior is recovered when the order of the fractional derivative is V = 1. We discuss possible biological implications.
文摘In modern days, biodegradable polymeric matrix used as the kingpin of local drug delivery system is in the center of attention. This work is concentrated on the formulation of mathematical model elucidating degradation of drug-loaded polymeric matrix followed by drug release to the adjacent biological tissues. Polymeric degradation is penciled with mass conservation equations. Drug release phenomenon is modeled by considering solubilization dynamics of drug particles, diffusion of the solubilized drug through polymeric matrix along with reversible dissociation/recrystallization process. In the tissue phase, reversible dissociation/association along with internalization processes of drug are taken into account. For this, a two-phase spatio-temporal model is postu- lated, which has ensued to a system of partial differential equations. They are solved analytically with appropriate choice of initial, interface and boundary conditions. In order to reflect the potency of the advocated model, the simulated results are analogized with corresponding experimental data and found laudable agreement so as to validate the applicability of the model considered. This model seems to foster the delicacy of the mantle enacted by important drug kinetic parameters such as diffusion coefficients, mass transfer coefficients, particle binding and internalization parameters, which is illustrated through local sensitivity analysis.
文摘In this paper, we extensively studied a mathematical model of biology. It helps us to understand the dynamical procedure of population changes in biological population model and provides valuable predictions. In this model, we establish a variety of exact solutions. To study the exact solutions, we used a fractional complex transform to convert the particular partial differential equation of fractional order into corresponding partial differential equation and modified exp-function method is implemented to investigate the nonlinear equation. Graphical demonstrations along with the numerical data reinforce the efficacy of the used procedure. The specified idea is very effective, unfailing, well-organized and pragmatic for fractional PDEs and could be protracted to further physical happenings.
文摘In this paper, we apply the method of directly defining the inverse mapping introduced by Liao and Zhao [On the method of directly defining inverse mapping for nonlinear differential equations, Numer. Algorithms 72（4） （2016） 989-1020] to the problem of prostate cancer immunotherapy. We extend this method in two directions： first, we apply the method to a system of nonlinear ordinary differential equation, and second, we propose a new technique for finding the base functions in the considered algorithm.
文摘Mathematical models and computer simulations are useful experimental tools for building and testing theories. Many mathematical models in biology can be formulated by a nonlinear system of ordinary differential equations. This work deals with the numerical solution of the hantavirus infection model, the human immunodeficiency virus （HIV） infection model of CD4^＋T cells and the susceptible-infected-removed （SIR） epidemic model using a new reliable algorithm based on shifted Boubaker Lagrangian （SBL） method. This method reduces the solution of such system to a system of linear or non- linear algebraic equations which are solved using the Newton iteration method. The obtained results of the proposed method show highly accurate and valid for an arbitrary finite interval. Also, those are compared with fourth-order Runge-Kutta （RK4） method and with the solutions obtained by some other methods in the literature.
文摘A modified mathematical model of hepatitis C viral dynamics has been presented in this paper, which is described by four coupled ordinary differential equations. The aim of this paper is to perform global stability analysis using geometric approach to stability, based on the higher-order generalization of Bendixson＇s criterion. The result is also supported numerically. An important epidemiological issue of eradicating hepatitis C virus has been addressed through the global stability analysis.
