A facile method to fabricate wettability pattern(two extreme wettabilities arranged in a pattern)to realize water self-pumping is proposed on cemented carbide while not necessarily depositing other materials on substr...A facile method to fabricate wettability pattern(two extreme wettabilities arranged in a pattern)to realize water self-pumping is proposed on cemented carbide while not necessarily depositing other materials on substrate surface.The water self-pumping is achieved by arranging wedge shaped superhydrophilic domain in superhydrophobic substrate using laser machining.Through single factor experiments,it is found that the key to the extreme wettabilities,micro⁃and nano⁃structures,is rendered by laser machining processes and is influenced by laser parameters.Meanwhile,the proper laser parameters that are used to fabricate required micro-and nano⁃structures are obtained.Finally,the water transport experiment is carried out,which shows that the velocity of water bulge could be up to 362 mm/s when the wedge angle is 3°.The mechanism of the water self-pumping is analyzed and it is found that the migration of water bulge is governed by Laplace pressure of the water bulge induced by the wedge micro-groove.展开更多
Recent years have seen the development of a number of mathematical models for the description of the simultaneous transport of microorganisms and bioreactive solutes in porous media. Most models are based on the adve...Recent years have seen the development of a number of mathematical models for the description of the simultaneous transport of microorganisms and bioreactive solutes in porous media. Most models are based on the advection dispersion equation, with terms added to account for interactions with the surfaces of the solid matrix, transformations and microbial activities. Those models based on the advection dispersion equation have all been shown to represent laboratory experimental data adequately although various assumptions have been made concerning the pore scale distribution of bacteria. This paper provides an overview of the recent work on modelling the transport and fate of microorganisms and bioreactive solutes in porous media and examines the different assumptions regarding the pore scale distribution of microorganisms.展开更多
Micro arc oxidation(MAO) and electrophoretic deposition(EPD) process are employed to fabricate a dense coating on magnesium alloy to protect it from corrosion in engineering application. The EPD film changes the dampi...Micro arc oxidation(MAO) and electrophoretic deposition(EPD) process are employed to fabricate a dense coating on magnesium alloy to protect it from corrosion in engineering application. The EPD film changes the damping characteristic of magnesium alloy, and both the MAO and EPD process change the bending stiffness of samples being treated. Damping loss factor(DLF) test and sound transmission experiments were carried out for AZ31 B magnesium alloy with coating fabricated by MAO and EPD processes. The results indicate that DLF is improved in frequency range from 0-850 Hz. Bending stiffness of the samples is improved with MAO and EPD treatment. As a result, the sound transmission loss(LST) is improved in the stiffness control stage of the sound transmission verse frequency curve. To the samples by electrophoresis process, the LST is improved in frequency range from 2500-3200 Hz, because the damping loss factor is improved with EPD process. The results are useful for the surface treatment to enhance the damping loss factor, LST and widespread application of magnesium alloy while improving the corrosion resistance.展开更多
Hyaluronan (HA), the consistent glycosaminoglycans in extracellular matrix, is a kind of biomaterials with wonderful biocompatibility. To develop drug release system (DDS) with HA as drug carrier is a new hotspot in t...Hyaluronan (HA), the consistent glycosaminoglycans in extracellular matrix, is a kind of biomaterials with wonderful biocompatibility. To develop drug release system (DDS) with HA as drug carrier is a new hotspot in the field of pharmaceutics. In this paper, we applied technique of ultrosound and reversed phase (Water/Oil) emulsification to develop dexamethasone (DEX)-HA-STMP cross-linking microspheres (DEX-HA MS) with STMP as cross-linker. DEX-HA MS has a wonderful shape and property of dispersion. There is a negative correlation between diameter of DEX-HA MS and the content of cross-linker, or the content of emulsifier, and a positive correlation between the diameter and CHA . When CHA≤1%,DEX/HA≤1/10 (g/g),there is a positive correlation between the factors mentioned below and drug loading (DL%)/loading efficiency (LE%),the content of STMP, the content of emulsifier,CHA and the content of DEX. DEX-HA-MS can realize function of slow release. In vitro drug release experiment shows that cumulative release (CR%) of DEX-HA MS fits in with pervasion-corrosion equation, and there is a negative correlation between the content of STMP, CHA and CR%, a positive correlation between emulsifier and CR%. When DEX/HA≤1/5 (g/g) there is a negative correlation between the content of DEX and CR%.展开更多
Microcarriers have a demonstrated value for biomedical applications,in particular for drug delivery and three-dimensional cell culture.Attempts to develop this technique tend to focus on the fabrication of functional ...Microcarriers have a demonstrated value for biomedical applications,in particular for drug delivery and three-dimensional cell culture.Attempts to develop this technique tend to focus on the fabrication of functional microparticles by using convenient methods with innovative but accessible materials.Inspired by the process of boiling eggs in everyday life,which causes the solidification of egg proteins,we present a new microfluidic‘‘cooking"approach for the generation of egg-derived microcarriers for cell culture and drug delivery.As the egg emulsion droplets are formed with exquisite precision during the microfluidic emulsification,the resultant egg microcarriers present highly monodisperse and uniform morphologies at the size range of hundred microns to one millimeter.Benefiting from the excellent biocompatibility of the egg protein components,the obtained microcarriers showed good performances of cell adherence and growth.In addition,after a freezing treatment,the egg microcarriers were shown to have interconnected porous structures throughout their whole sphere,could absorb and load different kinds of drugs or other active molecules,and work as microcarrier-based delivery systems.These features point to the potential value of the microfluidic egg microcarriers in biomedicine.展开更多
基金the National Natural Science Foundation of China(No.51875285)the Natural Science Foundation of Jiangsu Province(No.BK20190066)+1 种基金the Fundamental Research Funds for the Central Universities(No.NE2020005)the Foundation of the Graduate Innovation Center,Nanjing University of Aeronautics and Astronautics(No.kfjj20190508).
文摘A facile method to fabricate wettability pattern(two extreme wettabilities arranged in a pattern)to realize water self-pumping is proposed on cemented carbide while not necessarily depositing other materials on substrate surface.The water self-pumping is achieved by arranging wedge shaped superhydrophilic domain in superhydrophobic substrate using laser machining.Through single factor experiments,it is found that the key to the extreme wettabilities,micro⁃and nano⁃structures,is rendered by laser machining processes and is influenced by laser parameters.Meanwhile,the proper laser parameters that are used to fabricate required micro-and nano⁃structures are obtained.Finally,the water transport experiment is carried out,which shows that the velocity of water bulge could be up to 362 mm/s when the wedge angle is 3°.The mechanism of the water self-pumping is analyzed and it is found that the migration of water bulge is governed by Laplace pressure of the water bulge induced by the wedge micro-groove.
文摘Recent years have seen the development of a number of mathematical models for the description of the simultaneous transport of microorganisms and bioreactive solutes in porous media. Most models are based on the advection dispersion equation, with terms added to account for interactions with the surfaces of the solid matrix, transformations and microbial activities. Those models based on the advection dispersion equation have all been shown to represent laboratory experimental data adequately although various assumptions have been made concerning the pore scale distribution of bacteria. This paper provides an overview of the recent work on modelling the transport and fate of microorganisms and bioreactive solutes in porous media and examines the different assumptions regarding the pore scale distribution of microorganisms.
基金Project(2011BAE22B05)supported by National Technology R&D Program in the 12th Five year Plan of ChinaProject(2011DFA50900)supported by the Canada-China-USA Collaborative Research&Development ProjectProject(51071121)supported by the National Natural Science Foundation of China
文摘Micro arc oxidation(MAO) and electrophoretic deposition(EPD) process are employed to fabricate a dense coating on magnesium alloy to protect it from corrosion in engineering application. The EPD film changes the damping characteristic of magnesium alloy, and both the MAO and EPD process change the bending stiffness of samples being treated. Damping loss factor(DLF) test and sound transmission experiments were carried out for AZ31 B magnesium alloy with coating fabricated by MAO and EPD processes. The results indicate that DLF is improved in frequency range from 0-850 Hz. Bending stiffness of the samples is improved with MAO and EPD treatment. As a result, the sound transmission loss(LST) is improved in the stiffness control stage of the sound transmission verse frequency curve. To the samples by electrophoresis process, the LST is improved in frequency range from 2500-3200 Hz, because the damping loss factor is improved with EPD process. The results are useful for the surface treatment to enhance the damping loss factor, LST and widespread application of magnesium alloy while improving the corrosion resistance.
文摘Hyaluronan (HA), the consistent glycosaminoglycans in extracellular matrix, is a kind of biomaterials with wonderful biocompatibility. To develop drug release system (DDS) with HA as drug carrier is a new hotspot in the field of pharmaceutics. In this paper, we applied technique of ultrosound and reversed phase (Water/Oil) emulsification to develop dexamethasone (DEX)-HA-STMP cross-linking microspheres (DEX-HA MS) with STMP as cross-linker. DEX-HA MS has a wonderful shape and property of dispersion. There is a negative correlation between diameter of DEX-HA MS and the content of cross-linker, or the content of emulsifier, and a positive correlation between the diameter and CHA . When CHA≤1%,DEX/HA≤1/10 (g/g),there is a positive correlation between the factors mentioned below and drug loading (DL%)/loading efficiency (LE%),the content of STMP, the content of emulsifier,CHA and the content of DEX. DEX-HA-MS can realize function of slow release. In vitro drug release experiment shows that cumulative release (CR%) of DEX-HA MS fits in with pervasion-corrosion equation, and there is a negative correlation between the content of STMP, CHA and CR%, a positive correlation between emulsifier and CR%. When DEX/HA≤1/5 (g/g) there is a negative correlation between the content of DEX and CR%.
基金supported by the National Natural Science Foundation of China (21473029, 51522302)the NSAF Foundation of China (U1530260)+2 种基金the Natural Science Foundation of Jiangsu Province (BK20140028)the Program for New Century Excellent Talents in Universitythe Scientific Research Foundation of Southeast University
文摘Microcarriers have a demonstrated value for biomedical applications,in particular for drug delivery and three-dimensional cell culture.Attempts to develop this technique tend to focus on the fabrication of functional microparticles by using convenient methods with innovative but accessible materials.Inspired by the process of boiling eggs in everyday life,which causes the solidification of egg proteins,we present a new microfluidic‘‘cooking"approach for the generation of egg-derived microcarriers for cell culture and drug delivery.As the egg emulsion droplets are formed with exquisite precision during the microfluidic emulsification,the resultant egg microcarriers present highly monodisperse and uniform morphologies at the size range of hundred microns to one millimeter.Benefiting from the excellent biocompatibility of the egg protein components,the obtained microcarriers showed good performances of cell adherence and growth.In addition,after a freezing treatment,the egg microcarriers were shown to have interconnected porous structures throughout their whole sphere,could absorb and load different kinds of drugs or other active molecules,and work as microcarrier-based delivery systems.These features point to the potential value of the microfluidic egg microcarriers in biomedicine.
