目的观察淫羊藿提取物对急性心肌缺血模型犬血气的影响。方法将实验犬24只,随机分为4组(每组6只):模型组、阳性对照药地奥心血康胶囊组及淫羊藿提取物(生药52.0、104.0 m g/kg)组。采用结扎麻醉开胸犬左冠状动脉前降支制备急性心肌缺血...目的观察淫羊藿提取物对急性心肌缺血模型犬血气的影响。方法将实验犬24只,随机分为4组(每组6只):模型组、阳性对照药地奥心血康胶囊组及淫羊藿提取物(生药52.0、104.0 m g/kg)组。采用结扎麻醉开胸犬左冠状动脉前降支制备急性心肌缺血模型,经十二指肠1次性给药。观察240 min内对冠脉流量(CBF)动、静脉血氧饱和度,动、静脉氧分压,心肌耗氧量,心肌氧摄取率的影响。结果淫羊藿提取物增加CBF、静脉血氧饱和度、静脉氧分压,降低心肌氧摄取率。结论淫羊藿提取物对实验性心肌缺血犬的心肌有保护作用。展开更多
OBJECTIVES: The aim of this study was to compare treadmill exercise(TEX) and dipyridamole stress on the uptake and retention of N-13 ammonia. BACKGROUND: Size and severity of stress-induced myocardial perfusion defect...OBJECTIVES: The aim of this study was to compare treadmill exercise(TEX) and dipyridamole stress on the uptake and retention of N-13 ammonia. BACKGROUND: Size and severity of stress-induced myocardial perfusion defects are clinically important. Because ammonia uptake and retention seems to be related to perfusion, viability, and metabolism, exercise stress might induce larger perfusion defects than dipyridamole stress. METHODS: Twenty-six patients underwent TEX and dipyridamole stress N-13 ammonia positron emission tomography(PET). Images were assessed with a 17-segment model and a five-point score. Summed stress score(SSS), summed rest score(SRS), and summed difference score(SDS) were calculated. Left ventricular(LV) defect sizes were measured quantitatively with a 70% threshold for abnormal perfusion. RESULTS: Compared with dipyridamole stress, TEX yielded larger SSS(9.1± 5.7 vs. 6.9± 5.9; p < 0.01), SDS(5.8± 4.7 vs. 3.7± 4.6; p < 0.02), and percentage of LV stress defect(19.3± 11.5% vs. 13.8± 13.6% ; p < 0.02). CONCLUSIONS: In patients achieving adequate exercise, TEX N-13 ammonia PET myocardial perfusion imaging(MPI) yields larger stress perfusion defects than dipyridamole stress and might reflect the true myocardial ischemic burden. Treadmill exercise might be the preferred method of stress for routine N 13 ammonia PET MPI.展开更多
文摘目的观察淫羊藿提取物对急性心肌缺血模型犬血气的影响。方法将实验犬24只,随机分为4组(每组6只):模型组、阳性对照药地奥心血康胶囊组及淫羊藿提取物(生药52.0、104.0 m g/kg)组。采用结扎麻醉开胸犬左冠状动脉前降支制备急性心肌缺血模型,经十二指肠1次性给药。观察240 min内对冠脉流量(CBF)动、静脉血氧饱和度,动、静脉氧分压,心肌耗氧量,心肌氧摄取率的影响。结果淫羊藿提取物增加CBF、静脉血氧饱和度、静脉氧分压,降低心肌氧摄取率。结论淫羊藿提取物对实验性心肌缺血犬的心肌有保护作用。
文摘OBJECTIVES: The aim of this study was to compare treadmill exercise(TEX) and dipyridamole stress on the uptake and retention of N-13 ammonia. BACKGROUND: Size and severity of stress-induced myocardial perfusion defects are clinically important. Because ammonia uptake and retention seems to be related to perfusion, viability, and metabolism, exercise stress might induce larger perfusion defects than dipyridamole stress. METHODS: Twenty-six patients underwent TEX and dipyridamole stress N-13 ammonia positron emission tomography(PET). Images were assessed with a 17-segment model and a five-point score. Summed stress score(SSS), summed rest score(SRS), and summed difference score(SDS) were calculated. Left ventricular(LV) defect sizes were measured quantitatively with a 70% threshold for abnormal perfusion. RESULTS: Compared with dipyridamole stress, TEX yielded larger SSS(9.1± 5.7 vs. 6.9± 5.9; p < 0.01), SDS(5.8± 4.7 vs. 3.7± 4.6; p < 0.02), and percentage of LV stress defect(19.3± 11.5% vs. 13.8± 13.6% ; p < 0.02). CONCLUSIONS: In patients achieving adequate exercise, TEX N-13 ammonia PET myocardial perfusion imaging(MPI) yields larger stress perfusion defects than dipyridamole stress and might reflect the true myocardial ischemic burden. Treadmill exercise might be the preferred method of stress for routine N 13 ammonia PET MPI.
