为探索有氧运动与心血管疾病患者心脏功能、脂质代谢和炎症关联性,通过检索PubMed、Embase、Scopus和中国知网(CNKI)数据库中有氧运动与心血管疾病患者心脏功能、脂质代谢和炎性因子影响的相关研究,利用RevMan5.4和R软件进行Meta和关联...为探索有氧运动与心血管疾病患者心脏功能、脂质代谢和炎症关联性,通过检索PubMed、Embase、Scopus和中国知网(CNKI)数据库中有氧运动与心血管疾病患者心脏功能、脂质代谢和炎性因子影响的相关研究,利用RevMan5.4和R软件进行Meta和关联性分析。结果表明:有氧运动显著降低了B型利钠肽(B-type natriuretic peptide,BNP)[标准化均数差(standardized mean difference,SMD)=-0.84,95%CI(-1.34,-0.34),P=0.001]、收缩压(SBP)[SMD=-0.55,95%CI(-0.86,-0.25),P=0.0004]和舒张压(DBP)[SMD=-0.99,95%CI(-1.67,-0.32),P=0.004]、LDL[SMD=-0.53,95%CI(-0.89,-0.18),P=0.003]和C-反应蛋白(CRP)[SMD=-0.53,95%CI(-0.90,-0.16),P=0.005]。CRP和HDL、LDL、DBP呈正相关,相关系数分别为0.35、0.26和0.28;CRP与SBP呈负相关,相关系数为-0.31。由此可见,心血管疾病患者参与有氧运动能够在一定程度改善心脏功能、脂质代谢和炎症因子水平,并且心脏功能和脂质代谢、炎症之间存在相关性。展开更多
骨桥蛋白(OPN)是由骨桥蛋白基因(SPP1)编码的主要参与多种细胞功能的配体蛋白,是一种带负电的,非胶原性骨基质糖蛋白的,多数在细胞外基质(ECM)中发挥作用的一类重要的配体蛋白分子。OPN由胎盘等多种组织表达,含有信号肽、精氨酸–甘氨...骨桥蛋白(OPN)是由骨桥蛋白基因(SPP1)编码的主要参与多种细胞功能的配体蛋白,是一种带负电的,非胶原性骨基质糖蛋白的,多数在细胞外基质(ECM)中发挥作用的一类重要的配体蛋白分子。OPN由胎盘等多种组织表达,含有信号肽、精氨酸–甘氨酸–天冬氨酸(Arg-Gly-Asp, RGD)、糖基化位点和肝素结合域等多种功能序列的转化相关性磷酸蛋白。多项研究证明OPN具有细胞粘附、细胞募集、细胞因子表达、信号转导、肿瘤发生和转移、细胞免疫、加速血管生成和纤维化等多种生物学功能,成为研究的热点,有意义的分子靶点不断被识别,逐渐成为疾病诊断和治疗的新靶标,本文对近年来OPN与心血管疾病的关系作简要综述。Osteopontin (OPN) is a negatively charged, non-collagenous bone matrix glycoprotein mainly in various cellular functions as a ligand protein. It is expressed in various tissues including placenta, and contains a signal peptide, arginine-glycinepartic acid (Arg-Gly-Asp, RGD), glycosylation sites, and heparin binding domains, among other functional sequences, as transforming-related acidic phosphoprotein. Numerous studies have shown that OPN has various biological functions such as cell adhesion, cell recruitment, cytokine expression, signalduction, tumorigenesis and metastasis, cellular immunity, angiogenesis, and fibrosis, making it a hot topic in research. Meaningful molecular targets continuously being identified, gradually becoming new targets for disease diagnosis and treatment. This article briefly reviews the relationship between OPN and cardiovascular diseases in recent years.展开更多
文摘为探索有氧运动与心血管疾病患者心脏功能、脂质代谢和炎症关联性,通过检索PubMed、Embase、Scopus和中国知网(CNKI)数据库中有氧运动与心血管疾病患者心脏功能、脂质代谢和炎性因子影响的相关研究,利用RevMan5.4和R软件进行Meta和关联性分析。结果表明:有氧运动显著降低了B型利钠肽(B-type natriuretic peptide,BNP)[标准化均数差(standardized mean difference,SMD)=-0.84,95%CI(-1.34,-0.34),P=0.001]、收缩压(SBP)[SMD=-0.55,95%CI(-0.86,-0.25),P=0.0004]和舒张压(DBP)[SMD=-0.99,95%CI(-1.67,-0.32),P=0.004]、LDL[SMD=-0.53,95%CI(-0.89,-0.18),P=0.003]和C-反应蛋白(CRP)[SMD=-0.53,95%CI(-0.90,-0.16),P=0.005]。CRP和HDL、LDL、DBP呈正相关,相关系数分别为0.35、0.26和0.28;CRP与SBP呈负相关,相关系数为-0.31。由此可见,心血管疾病患者参与有氧运动能够在一定程度改善心脏功能、脂质代谢和炎症因子水平,并且心脏功能和脂质代谢、炎症之间存在相关性。
文摘骨桥蛋白(OPN)是由骨桥蛋白基因(SPP1)编码的主要参与多种细胞功能的配体蛋白,是一种带负电的,非胶原性骨基质糖蛋白的,多数在细胞外基质(ECM)中发挥作用的一类重要的配体蛋白分子。OPN由胎盘等多种组织表达,含有信号肽、精氨酸–甘氨酸–天冬氨酸(Arg-Gly-Asp, RGD)、糖基化位点和肝素结合域等多种功能序列的转化相关性磷酸蛋白。多项研究证明OPN具有细胞粘附、细胞募集、细胞因子表达、信号转导、肿瘤发生和转移、细胞免疫、加速血管生成和纤维化等多种生物学功能,成为研究的热点,有意义的分子靶点不断被识别,逐渐成为疾病诊断和治疗的新靶标,本文对近年来OPN与心血管疾病的关系作简要综述。Osteopontin (OPN) is a negatively charged, non-collagenous bone matrix glycoprotein mainly in various cellular functions as a ligand protein. It is expressed in various tissues including placenta, and contains a signal peptide, arginine-glycinepartic acid (Arg-Gly-Asp, RGD), glycosylation sites, and heparin binding domains, among other functional sequences, as transforming-related acidic phosphoprotein. Numerous studies have shown that OPN has various biological functions such as cell adhesion, cell recruitment, cytokine expression, signalduction, tumorigenesis and metastasis, cellular immunity, angiogenesis, and fibrosis, making it a hot topic in research. Meaningful molecular targets continuously being identified, gradually becoming new targets for disease diagnosis and treatment. This article briefly reviews the relationship between OPN and cardiovascular diseases in recent years.
