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2017年至2023年江西省某皮肤病医院门诊性病、艾滋病流行特征分析
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作者 戴桂霞 王春红 +2 位作者 刘丹 魏仁红 郭亮 《江西医药》 CAS 2024年第7期688-693,共6页
目的分析江西省某皮肤病医院2017年至2023年门诊报告的性病、艾滋病,了解其发病规律,探讨和完善防治策略,进一步做好重点人群的健康教育工作。方法采用描述流行病学分析门诊性传播疾病的三间分布,Excel、SPSS软件对相关数据进行统计分... 目的分析江西省某皮肤病医院2017年至2023年门诊报告的性病、艾滋病,了解其发病规律,探讨和完善防治策略,进一步做好重点人群的健康教育工作。方法采用描述流行病学分析门诊性传播疾病的三间分布,Excel、SPSS软件对相关数据进行统计分析。结果2017年至2023年门诊累计上报性病、艾滋病1110例,男女性别比为3.04∶1,报告基本集中在15~49岁的中青年之间,发病职业主要为家务及待业和商业服务。大专及以上学历患者占比较重,不同性接触史与学历之间差异有统计学意义(χ^(2)=95.748,P<0.01)。已婚患者占比最高,不同性接触史与婚姻之间差异有统计学意义(χ^(2)=31.481,P<0.01)。接触史以“非婚异性接触史”为主。艾滋病及同性传播患者有性病史的比例较高。结论门诊性传播疾病患者主要为男性中青年,职业为家务及待业和商业服务,以“非婚异性接触史”及异性传播为主。需对此类患者加强宣传,提高预防意识和能力,医院强化疫情报告质量管理,扩大干预、检测范围,早发现、早干预、早治疗,减少性传播疾病的发生和传播。 展开更多
关键词 皮肤病医院 门诊性病、艾滋病 流行特征分析
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江西省2014年低档暗娼性病、艾滋病知信行现状的调查研究 被引量:5
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作者 彭伊婧 周小军 +3 位作者 成慧 付俊 曾艺旋 周慧 《南昌大学学报(医学版)》 CAS 2018年第2期81-86,共6页
目的了解江西省不同类型低档暗娼的构成特征、行为和性病、获得性免疫缺陷综合征(艾滋病)知识及感染现状,探讨性病、艾滋病预防控制对策。方法采用分层抽样法,对江西省的站街女暗娼与固定低档场所暗娼的性病、艾滋病相关知识知晓情况、... 目的了解江西省不同类型低档暗娼的构成特征、行为和性病、获得性免疫缺陷综合征(艾滋病)知识及感染现状,探讨性病、艾滋病预防控制对策。方法采用分层抽样法,对江西省的站街女暗娼与固定低档场所暗娼的性病、艾滋病相关知识知晓情况、安全套使用情况、接受相关服务情况及性病、艾滋病患病情况进行调查,并采用SPSS19.0软件进行统计分析。结果共调查543名低档暗娼,其中站街女暗娼233人,固定低档场所暗娼310人。与站街女暗娼比较,固定低档场所暗娼呈现文化程度高、未婚者多、本省所占比例大(均P<0.01)。两类暗娼的艾滋病知识总体知晓率比较差异无统计学意义(P>0.05)。固定低档场所暗娼"最近一次"和"最近一个月"与客人发生性行为时使用安全套的频率均高于站街女暗娼(均P<0.05)。站街女暗娼接受预防艾滋病的宣传教育、培训等活动和生殖健康等方面知识的教育、培训的所占比例均高于固定低档场所暗娼(均P<0.05),但接受同伴宣传艾滋病知识和发放安全套所占比例低于固定低档场所暗娼(P<0.05)。两类暗娼最近一年出现性病相关症状后的就诊流向和性病患病率比较差异均无统计学意义(均P>0.05)。结论宜以安全套免费发放和性病、艾滋病知识教育、同伴教育等干预服务为重点,加强对站街女暗娼的干预,提倡安全性行为,提升安全套使用频率,有效抑制性病、艾滋病的发生与传播。 展开更多
关键词 低档暗娼 行为特征 安全套使用 性病、艾滋病知识
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娱乐场所人员性病 艾滋病监测及健康教育 被引量:5
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作者 潘洪娟 《基层医学论坛》 2011年第4期186-187,共2页
目的了解娱乐场所人群性病、艾滋病感染情况及其知识知晓情况。方法 2008年1月—2009年7月对提供性服务的152名娱乐场所人员进行HIV及性病检测与调查,同时随机采用匿名问卷调查185名娱乐场所人员对性病、艾滋病知识了解情况。结果检出HI... 目的了解娱乐场所人群性病、艾滋病感染情况及其知识知晓情况。方法 2008年1月—2009年7月对提供性服务的152名娱乐场所人员进行HIV及性病检测与调查,同时随机采用匿名问卷调查185名娱乐场所人员对性病、艾滋病知识了解情况。结果检出HIV阳性血清7例,淋病3例,宫颈糜烂4例,梅毒RPR阳性结果5例。有175份匿名问卷完成调查,其中能够正确回答预防性病、艾滋病知识的有32名,其认识程度占调查对象的21.0%,愿意和偶尔使用安全套的有22名,占调查对象的12.6%.结论娱乐场所人员性病、艾滋病知识知晓率较低,安全套使用率较低,应加强对高危人群的健康教育并进行正确用套行为干预。 展开更多
关键词 娱乐场所 性病、艾滋病 健康教育 行为干预
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140例女性性工作者AIDS/STD血清学和行为学调查
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作者 赵树海 王继杰 +3 位作者 方彰红 颜天强 何伟 彭颂阳 《实用预防医学》 CAS 2007年第6期1926-1927,共2页
目的了解湘潭市市区女性性工作者性病、艾滋病流行现状和行为学特征,为该人群的有效干预提供依据。方法对公安系统现场抓捕的女性性工作者进行血清学检查及行为学调查,应用SPSS10.0软件进行资料统计分析。结果140名女性性工作者中发现HI... 目的了解湘潭市市区女性性工作者性病、艾滋病流行现状和行为学特征,为该人群的有效干预提供依据。方法对公安系统现场抓捕的女性性工作者进行血清学检查及行为学调查,应用SPSS10.0软件进行资料统计分析。结果140名女性性工作者中发现HIV抗体阳性1名,梅毒抗体阳性10名。安全套使用率为37.14%。结论目前湘潭市女性性工作者安全套使用率仍然较低,易造成性病、艾滋病传播,需加强干预措施,控制疾病的传播和蔓延。 展开更多
关键词 女性性工作者 性病、艾滋病 咨询检测
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Condom Use in Commercial Sex Workers and Clients Among Incarcerated Sexworkers and STD Clinic Attendees in Jinan, Shandong Province
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作者 陈树民 李冰 +2 位作者 刘殿昌 李长玲 裴振环 《Chinese Journal of Sexually Transmitted Infections》 2003年第2期1-8,66,共9页
Background: Commercial sex workers and clientsare important core populations in the transmission ofsexually transmitted diseases (STDs) and human im-munodeficiency virus (HIV) infection. Research on thefrequency and d... Background: Commercial sex workers and clientsare important core populations in the transmission ofsexually transmitted diseases (STDs) and human im-munodeficiency virus (HIV) infection. Research on thefrequency and determinants of condom use in com-mercial sex workers and their clients is important inincreasing condom use and reduction of the STD/HIV.Burden. Objectives: To establish the frequency of and fac-tors related to intention to use condoms and actualcondom use in commercial sex contacts and to deter-mine the differences in condom use between sex work-ers and clients.Methods: Incarcerated commercial sex workers(ICSW) and male STD clinic attendees were recruitedinto a cross-sectional study to obtain data on the fre-quency and factors associated with intention to usecondoms and condom use in commercial sexual con-tacts with an interviewer-administered questionnaire.Consistent condom use in ICSWs and never usingcondoms in male STD clinic attendees were analyzedusing univariate and multivariate logistic regressionmodels. Results: The frequency of reported consistent in-tention to use condoms and reported actual condomuse was 62% and 50.6%, respectively among 158ICSWs. For male STD clinic attendees, the propor-tion of reported consistent intention to use condomsand reported actual condom use was 10% and 20.7%,respectively. The factors positively influencing theconsistent intention to use condoms were pregnancypreventing measures and the belief of condom efficacyin the prevention of STD/HIV, whereas the factor as-sociated with actually consistent condom use was preg-nancy-preventing measure in ICSWs. Factors associ-ated with no intention to use condoms were low income,low STD/HIV knowledge level and the frequency ofvisiting CSW. The latter factor was also associatedwith never using condoms in male STD clinicattendees. Conclusions: Consistent condom use during com-mercial sex contacts was low, especially in clients.Greater effort is needed in condom promotion programin order to raise the level of condom use in commer-cial sex contacts. 展开更多
关键词 condom use commercial sex worker CLIENT STD/HIV
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Acute hepatitis C in a chronically HIV-infected patient:Evolution of different viral genomic regions 被引量:2
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作者 Diego Flichman Veronica Kott +1 位作者 Silvia Sookoian Rodolfo Campos 《World Journal of Gastroenterology》 SCIE CAS CSCD 2003年第7期1496-1500,共5页
AIM: To analyze the molecular evolution of different viral genomic regions of HCV in an acute HCV infected patient chronically infected with HIV through a 42-month follow-up.METHODS: Serum samples of a chronically HIV... AIM: To analyze the molecular evolution of different viral genomic regions of HCV in an acute HCV infected patient chronically infected with HIV through a 42-month follow-up.METHODS: Serum samples of a chronically HIV infected patient that seroconverted to anti HCV antibodies were sequenced, from the event of superinfection through a period of 17 months and in a late sample (42nd month). Hypervariable genomic regions of HIV (V3 loop of the gp120) and HCV (HVR-1 on the E2 glycoprotein gene) were studied. In order to analyze genomic regions involved in different biological functions and with the cellular immune response, HCV core and NS5A were also chosen to be sequenced. Amplification of the different regions was done by RT-PCR and directly sequenced. Confirmation of sequences was done on reamplified material. Nucleotide sequences of the different time points were aligned with CLUSTAL W 1.5, and the corresponding amino acid ones were deduced.RESULTS: Hypervariable genomic regions of both viruses (HVR1 and gp120 V3 loop) presented several nonsynonymous changes but, while in the gp120 V3 loop mutations were detected in the sample obtained right after HCV superinfection and maintained throughout, they occurred following a sequential and cumulative pattern in the HVR1. In the NS5A region of HCV, two amino acid changes were detected during the follow-up period, whereas the core region presented several amino acid replacements, once the HCV chronic infection had been established.CONCLUSION: During the HIV-HCV superinfection, each genomic region analyzed shows a different evolutionary pattem.Most of the nucleotide substitutions observed are nonsynonymous and clustered in previously described epitopes,thus suggesting an immune-driven evolutionary process. 展开更多
关键词 Acute Disease Adolescent Amino Acid Sequence Female Genome Viral HIV HIV Envelope Protein gp120 HIV Infections HEPACIVIRUS Hepatitis C Humans Molecular Sequence Data Research Support Non-U.S. Gov't SUPERINFECTION Viral Nonstructural Proteins Viral Proteins
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A Few Specialized Issues That Should Be Focused on Anti-HIV Drug Evaluation In Vitro
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作者 Dao-min ZHUANG Jing-yun LI 《Virologica Sinica》 SCIE CAS CSCD 2010年第4期301-306,共6页
Since the introduction of antiretroviral therapy (ART), the lifespan and quality of life of patients infected with HIV have been significantly improved. But treatment efficacy was compromised eventually by the develop... Since the introduction of antiretroviral therapy (ART), the lifespan and quality of life of patients infected with HIV have been significantly improved. But treatment efficacy was compromised eventually by the development of resistance to antiretroviral drugs, and more new anti-HIV drugs with lower toxicity and higher activity were needed. Based on the experience and lessons learned from the treatment in the developed countries, US FDA suggested that more pharmacodynamical researches should be considered ahead of the clinical trials. To facilitate the anti-HIV drug research and development, we reviewed a few specialized issues that should be focused on drug evaluations in vitro, including: 1) Mechanism of action studies, demonstrating the candidate drug's efficacy to specifically inhibit viral replication or a virus-specific function and confirm the drug target. 2) Drug resistance studies, selecting the drug-resistant variants in vitro and determining the activities inhibiting HIV isolates resistant to approved antiretroviral drugs of the same class. 3) Antiviral activity in vitro in the presence of serum proteins, ascertaining whether an investigational product is significantly bound by serum proteins. 4) Combination activity analysis, evaluating in vitro antiviral activity of an investigational product in two-drug combinations with other drugs approved. 展开更多
关键词 Human immunodeficiency virus Drug evaluation Drug resistance
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Clinical Analysis of 10 AIDS Patients with Malignant Lymphoma 被引量:4
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作者 Gui-ju Gao Di Yang +6 位作者 Ke-ke Lin Jiang Xiao Xin Li Hong-yuan Liang Long Liu Ning Han Hong-xin Zhao 《Clinical oncology and cancer researeh》 CAS CSCD 2012年第2期115-119,共5页
Objective This work summarizes the clinical features and treatment of 10 AIDS patients with malignant lymphoma. Methods A total of 10 AIDS patients with malignant lymphoma seen in Beijing Ditan Hospital since 2009 wer... Objective This work summarizes the clinical features and treatment of 10 AIDS patients with malignant lymphoma. Methods A total of 10 AIDS patients with malignant lymphoma seen in Beijing Ditan Hospital since 2009 were enrolled. Clinical manifestations, pathological examinations, immunity levels, Epstein-Barr virus antibody examinations, complications, treatments, and outcomes were retrospectively analyzed. Results The main clinical manifestations of these patients included intermittent fever in 2 cases, neck masses and fever in 3 cases, auxiliary lymph node enlargement in 2 cases, and abdominal pain and bloating with fever in 3 cases. Up to 7 patients were pathologically diagnosed with diffuse large B cell lymphoma (DLBCL), and 3 patients were pathologically diagnosed with Burkitt's lymphoma. Up to 8 patients had CD4 cell counts below 200/μL, and 2 patients had a level of more than 200/μL. Up to 7 patients were negative for EBV-IgM antibodies and 3 patients were not examined. Six patients underwent different chemotherapy and their prognoses were different. One patient with Burkitt's lymphoma alternatively took CODOXM and IVAC for 3 turns after VP chemotherapy; 1 patient with liver metastasis took R-CHOP 5 times, then changed therapy regimen to R-MINE and MINE. One patient with adrenal DLBCL took CHOP 6 times. Three patients with DLBCL took CHOP 1 or 2 times. Four patients gave up treatment. Various infections and side effects occurred, including bone marrow suppression, gastrointestinal bleeding, and renal dysfunction during chemotherapy. Six patients took HAARI, and 4 did not. Six patients died, whereas 3 patients got improved; and 1 patient was discharged. Conclusions AIDS patients with malignant lymphoma had various clinical manifestations, were immunocompromised, and had multiple metastases when they were admitted; they were already in the interim or late stage of lymphoma. Chemotherapy was not effective, and additional complications occurred. HAART failed to improve patient prognosis, and the overall prognosis was poor. 展开更多
关键词 acquired immunodeficiency syndrome (AIDS) malignant lymphoma CHEMOTHERAPY HAART. prognosis
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Recent advance in the structural analysis of HIV-1 envelope protein
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作者 MATSUDA Zene 《Science China(Life Sciences)》 SCIE CAS CSCD 2015年第5期420-424,共5页
Human immunodeficiency virus type 1 (HIV-1), a causative agent of AIDS, is affecting today more than 35 millions of people worldwide. The advance of anti-HIV chemotherapy has made AIDS a chronic non-fatal disease in... Human immunodeficiency virus type 1 (HIV-1), a causative agent of AIDS, is affecting today more than 35 millions of people worldwide. The advance of anti-HIV chemotherapy has made AIDS a chronic non-fatal disease in resourceful countries. Longawaited anti-HIV-1 vaccine is still not with us yet; however, great progress in structural analyses of the envelope protein of HIV-1 in recent years starts to shed light on rational intervention targeted at the envelope protein, as will be reviewed in this article. 展开更多
关键词 HIV-1 envelope glycuprotein CRYOEM structure membrane fusion VACCINE
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