慢性前列腺炎(CP)是前列腺炎中最常见者,患者通常以长期反复的骨盆区域疼痛为主要表现。CP的发病机制复杂,涉及多种环节,具有临床症状持续、难以治愈、容易复发等疾病特点,给患者带来严重负担。西医对本病的治疗方式较为单一,药物不良...慢性前列腺炎(CP)是前列腺炎中最常见者,患者通常以长期反复的骨盆区域疼痛为主要表现。CP的发病机制复杂,涉及多种环节,具有临床症状持续、难以治愈、容易复发等疾病特点,给患者带来严重负担。西医对本病的治疗方式较为单一,药物不良反应较多,中医药治疗CP历史悠久,治疗方式多样。笔者通过综述近年来中医药治疗CP的临床研究发现,中医药治疗CP疗效确切,安全性高,可通过改善炎症反应、调控内分泌细胞等机制来改善患者临床症状,提高生活质量,一些特色治疗方法如中药熏洗、针灸等表现出了明显的治疗优势。未来需要更多大规模的多中心随机对照研究来探究中医药治疗CP的深层次机制,以提高中医药治疗本病的可信度。Chronic prostatitis (CP) is the most common form of prostatitis, and patients usually have persistent and recurrent pelvic pain as their main symptoms. The pathogenesis of CP is complex and involves multiple mechanisms, with clinical symptoms persisting, being difficult to cure, and being prone to recurrence, which brings serious burdens to patients. Western medicine has a relatively single treatment approach for this disease, with many adverse drug reactions, while traditional Chinese medicine has a long history of treating CP and has diverse treatment methods. Through a review of the recent clinical research on the treatment of CP with traditional Chinese medicine, the authors found that traditional Chinese medicine has a definite therapeutic effect and high safety, and can improve patients’ clinical symptoms by improving inflammatory responses and regulating endocrine cells. Some unique treatment methods such as herbal bath and acupuncture have shown obvious therapeutic advantages. In the future, more large-scale, multicenter, randomized controlled trials are needed to explore the deep-level mechanisms of traditional Chinese medicine in the treatment of CP, in order to enhance the credibility of traditional Chinese medicine in the treatment of this disease.展开更多
本文基于“前列腺–膀胱跨器官敏化”学说,挖掘中医改善慢性前列腺炎下尿路发生机制,其中核心靶点:1) 盆腔神经激活;2) 膀胱过度活跃;3) 神经生长因子过度表达等。中医方面:从中药药理学分析获得缓解慢性前列腺炎下尿路症状的主要活性成...本文基于“前列腺–膀胱跨器官敏化”学说,挖掘中医改善慢性前列腺炎下尿路发生机制,其中核心靶点:1) 盆腔神经激活;2) 膀胱过度活跃;3) 神经生长因子过度表达等。中医方面:从中药药理学分析获得缓解慢性前列腺炎下尿路症状的主要活性成分,利用网络数据库获取主要成分的药物靶点,揭示了中医在:1) 单味中药:黄芪、肉苁蓉、石斛等,能够多成分、多靶点、多通路协同调控缓解慢性前列腺炎下尿路症状;2) 方剂:栝蒌瞿麦丸合桃核承气汤缓解湿热瘀滞型CP及三黄清淋汤与盐酸坦洛新缓释片协同缓解CP症状;3) 针灸:针刺取穴关元、中极、气海、三阴交等缓解慢性前列腺炎下尿路症状。发现中医可通过靶向作用于慢性前列腺炎具体发病通路,进而证明“前列腺–膀胱跨器官敏化”学说的可行性,为临床提供了新的理论依据及研究思路。Based on the theory of “prostate-bladder cross-organ sensitization”, this paper explores the mechanism of traditional Chinese medicine in improving the lower urinary tract of chronic prostatitis, including the core targets: 1) Pelvic nerve activation;2) Overactive bladder;3) Nerve growth factor over-expression. As for traditional Chinese medicine (TCM), we obtained the main active ingredients to relieve the lower urinary tract symptoms of chronic prostatitis from the pharmacological analysis of traditional Chinese medicine, and obtained the drug targets of the main ingredients by using the network database. It is revealed that TCM can relieve the lower urinary tract symptoms of chronic prostatitis with multi-component, multi-target and multi-pathway synergistic regulation: 1) single Chinese medicine: Astragalus membranaceus, Cistanche, Dendrobium, etc. 2) Prescription: Gualou Qumai Pill and Taohe Chengqi decoction for relieving CP of damp-heat and blood stasis, Sanhuang Qinglin decoction and tamsulosin hydrochloride sustained release tablets for relieving CP symptoms;3) Acupuncture: acupuncture was applied at Guanyuan (CV 4), Zhongji (CV 3), Qihai (CV 6), Sanyinjiao (SP 6), etc. to relieve the lower urinary tract symptoms of chronic prostatitis. It is found that TCM can target the specific pathogenesis pathway of chronic prostatitis, and thus prove the feasibility of the theory of “prostate-bladder cross-organ sensitization”, which provides a new theoretical basis and research ideas for clinical practice.展开更多
文摘慢性前列腺炎(CP)是前列腺炎中最常见者,患者通常以长期反复的骨盆区域疼痛为主要表现。CP的发病机制复杂,涉及多种环节,具有临床症状持续、难以治愈、容易复发等疾病特点,给患者带来严重负担。西医对本病的治疗方式较为单一,药物不良反应较多,中医药治疗CP历史悠久,治疗方式多样。笔者通过综述近年来中医药治疗CP的临床研究发现,中医药治疗CP疗效确切,安全性高,可通过改善炎症反应、调控内分泌细胞等机制来改善患者临床症状,提高生活质量,一些特色治疗方法如中药熏洗、针灸等表现出了明显的治疗优势。未来需要更多大规模的多中心随机对照研究来探究中医药治疗CP的深层次机制,以提高中医药治疗本病的可信度。Chronic prostatitis (CP) is the most common form of prostatitis, and patients usually have persistent and recurrent pelvic pain as their main symptoms. The pathogenesis of CP is complex and involves multiple mechanisms, with clinical symptoms persisting, being difficult to cure, and being prone to recurrence, which brings serious burdens to patients. Western medicine has a relatively single treatment approach for this disease, with many adverse drug reactions, while traditional Chinese medicine has a long history of treating CP and has diverse treatment methods. Through a review of the recent clinical research on the treatment of CP with traditional Chinese medicine, the authors found that traditional Chinese medicine has a definite therapeutic effect and high safety, and can improve patients’ clinical symptoms by improving inflammatory responses and regulating endocrine cells. Some unique treatment methods such as herbal bath and acupuncture have shown obvious therapeutic advantages. In the future, more large-scale, multicenter, randomized controlled trials are needed to explore the deep-level mechanisms of traditional Chinese medicine in the treatment of CP, in order to enhance the credibility of traditional Chinese medicine in the treatment of this disease.
文摘本文基于“前列腺–膀胱跨器官敏化”学说,挖掘中医改善慢性前列腺炎下尿路发生机制,其中核心靶点:1) 盆腔神经激活;2) 膀胱过度活跃;3) 神经生长因子过度表达等。中医方面:从中药药理学分析获得缓解慢性前列腺炎下尿路症状的主要活性成分,利用网络数据库获取主要成分的药物靶点,揭示了中医在:1) 单味中药:黄芪、肉苁蓉、石斛等,能够多成分、多靶点、多通路协同调控缓解慢性前列腺炎下尿路症状;2) 方剂:栝蒌瞿麦丸合桃核承气汤缓解湿热瘀滞型CP及三黄清淋汤与盐酸坦洛新缓释片协同缓解CP症状;3) 针灸:针刺取穴关元、中极、气海、三阴交等缓解慢性前列腺炎下尿路症状。发现中医可通过靶向作用于慢性前列腺炎具体发病通路,进而证明“前列腺–膀胱跨器官敏化”学说的可行性,为临床提供了新的理论依据及研究思路。Based on the theory of “prostate-bladder cross-organ sensitization”, this paper explores the mechanism of traditional Chinese medicine in improving the lower urinary tract of chronic prostatitis, including the core targets: 1) Pelvic nerve activation;2) Overactive bladder;3) Nerve growth factor over-expression. As for traditional Chinese medicine (TCM), we obtained the main active ingredients to relieve the lower urinary tract symptoms of chronic prostatitis from the pharmacological analysis of traditional Chinese medicine, and obtained the drug targets of the main ingredients by using the network database. It is revealed that TCM can relieve the lower urinary tract symptoms of chronic prostatitis with multi-component, multi-target and multi-pathway synergistic regulation: 1) single Chinese medicine: Astragalus membranaceus, Cistanche, Dendrobium, etc. 2) Prescription: Gualou Qumai Pill and Taohe Chengqi decoction for relieving CP of damp-heat and blood stasis, Sanhuang Qinglin decoction and tamsulosin hydrochloride sustained release tablets for relieving CP symptoms;3) Acupuncture: acupuncture was applied at Guanyuan (CV 4), Zhongji (CV 3), Qihai (CV 6), Sanyinjiao (SP 6), etc. to relieve the lower urinary tract symptoms of chronic prostatitis. It is found that TCM can target the specific pathogenesis pathway of chronic prostatitis, and thus prove the feasibility of the theory of “prostate-bladder cross-organ sensitization”, which provides a new theoretical basis and research ideas for clinical practice.
