Excessive fluid administration after cardiothoracic surgery has been proposed as a cause of postoperative atrial fibrillation. In this study, we observed that fluid balance and volume administered on postoperative day...Excessive fluid administration after cardiothoracic surgery has been proposed as a cause of postoperative atrial fibrillation. In this study, we observed that fluid balance and volume administered on postoperative day 2 was greater in pat ients who developed postoperative AF than in those who did not. We also found th at net fluid balance on postoperative day 2 was an independent predictor of post operative AF among patients not receiving prophylactic therapy.展开更多
Objective The objective of this study was to determine the effects of a ngioten sin-converting enzyme inhibition (ACEI)-versus long-acting calcium-channel b lockade(CCB) on atrial fibrillation(AF) in patients with hyp...Objective The objective of this study was to determine the effects of a ngioten sin-converting enzyme inhibition (ACEI)-versus long-acting calcium-channel b lockade(CCB) on atrial fibrillation(AF) in patients with hypertension. Backgroun d Atrial fibrillation is the most common significant cardiac arrhythmia, and ang iotensin II has been implicated in its pathophysiology. Methods This was a retro spective, longitudinal cohort study from a database of 8 million people in the U .S. Patients age ≥18 years with hypertension were eligible if they filled a pre scription for either an ACEI or a CCB between January 1995 and June 1999. The us e of all other antihypertensive medications was permitted. Patient chronic disea se burden was assessed using a modified Charlson index. Patients were matched on a propensity score generated from a logistic regression model. A survival analy sis approach was used to compare the incidence of AF between groups. The final c ohorts were evaluated until June 2002, and the average follow-up was 4.5 years. Results After cohort matching, 10,926 patients were included in the analysis an d divided equally into the ACEI and CCB groups. Mean patient age was 65 years. T he adjusted hazards ratio (95%confidence interval <<CI>>) in the ACEI versus CCB groups for the entire follow-up period was 0.85(95%CI: 0.74 to 0.97) for new- onset AF, and the adjusted incidence ratio for AF-related hospitalizations was 0.74(95%CI: 0.62 to 0.89). Conclusions Angiotensin-converting enzyme inhibitio n was associated with a reduced incidence of AF for patients with hypertension i n a usual care setting. These results need to be confirmed in a large-scale ran domized clinical trial.展开更多
Atrial fibrillation （AF） is an important health problem due to its association with serious complications.Ill Stroke is one of the most serious complications and is the leading cause of death and disabilities in thi...Atrial fibrillation （AF） is an important health problem due to its association with serious complications.Ill Stroke is one of the most serious complications and is the leading cause of death and disabilities in this population. AF in- creases the risk of embolic stroke five times compared to general population. The prevalence of AF varies from 0.5%-15% depending on studied populations such as age,展开更多
文摘Excessive fluid administration after cardiothoracic surgery has been proposed as a cause of postoperative atrial fibrillation. In this study, we observed that fluid balance and volume administered on postoperative day 2 was greater in pat ients who developed postoperative AF than in those who did not. We also found th at net fluid balance on postoperative day 2 was an independent predictor of post operative AF among patients not receiving prophylactic therapy.
文摘Objective The objective of this study was to determine the effects of a ngioten sin-converting enzyme inhibition (ACEI)-versus long-acting calcium-channel b lockade(CCB) on atrial fibrillation(AF) in patients with hypertension. Backgroun d Atrial fibrillation is the most common significant cardiac arrhythmia, and ang iotensin II has been implicated in its pathophysiology. Methods This was a retro spective, longitudinal cohort study from a database of 8 million people in the U .S. Patients age ≥18 years with hypertension were eligible if they filled a pre scription for either an ACEI or a CCB between January 1995 and June 1999. The us e of all other antihypertensive medications was permitted. Patient chronic disea se burden was assessed using a modified Charlson index. Patients were matched on a propensity score generated from a logistic regression model. A survival analy sis approach was used to compare the incidence of AF between groups. The final c ohorts were evaluated until June 2002, and the average follow-up was 4.5 years. Results After cohort matching, 10,926 patients were included in the analysis an d divided equally into the ACEI and CCB groups. Mean patient age was 65 years. T he adjusted hazards ratio (95%confidence interval <<CI>>) in the ACEI versus CCB groups for the entire follow-up period was 0.85(95%CI: 0.74 to 0.97) for new- onset AF, and the adjusted incidence ratio for AF-related hospitalizations was 0.74(95%CI: 0.62 to 0.89). Conclusions Angiotensin-converting enzyme inhibitio n was associated with a reduced incidence of AF for patients with hypertension i n a usual care setting. These results need to be confirmed in a large-scale ran domized clinical trial.
文摘Atrial fibrillation （AF） is an important health problem due to its association with serious complications.Ill Stroke is one of the most serious complications and is the leading cause of death and disabilities in this population. AF in- creases the risk of embolic stroke five times compared to general population. The prevalence of AF varies from 0.5%-15% depending on studied populations such as age,
