非心脏手术后心肌损伤(Myocardial Injury after Noncardiac Surgery, MINS)是围手术期常见的并发症,其诊断与评估对于改善患者预后具有重要意义。肌钙蛋白(Cardiac Troponin, cTn)作为心肌细胞的关键调节蛋白,是心肌损伤的重要标志物;...非心脏手术后心肌损伤(Myocardial Injury after Noncardiac Surgery, MINS)是围手术期常见的并发症,其诊断与评估对于改善患者预后具有重要意义。肌钙蛋白(Cardiac Troponin, cTn)作为心肌细胞的关键调节蛋白,是心肌损伤的重要标志物;脑钠肽(Brain Natriuretic Peptide, BNP)主要由心脏分泌,反映心脏功能及代偿能力。本文综述了肌钙蛋白与脑钠肽的生物学特征及MINS的相关影响因素,并提出联合检测能显著提高MINS诊断的敏感性和特异性。通过同时监测心肌损伤与心功能变化,为临床早期诊断和及时干预提供了有力支持。Myocardial injury after non cardiac surgery (MINS) is a common complication during the perioperative period, and its diagnosis and evaluation are of great significance for improving patient prognosis. Cardiac troponin (cTn), as a key regulatory protein of myocardial cells, its release is an important biomarker of myocardial injury. Brain Natriuretic Peptide (BNP) is mainly secreted by the heart, reflecting cardiac function and compensatory ability. This article reviews the biological characteristics of troponin and brain natriuretic peptide, as well as the related influencing factors of MINS. It proposes that combined detection can significantly improve the sensitivity and specificity of MINS diagnosis. By simultaneously monitoring myocardial injury and changes in heart function, it provides strong support for early clinical diagnosis and timely intervention.展开更多
文摘非心脏手术后心肌损伤(Myocardial Injury after Noncardiac Surgery, MINS)是围手术期常见的并发症,其诊断与评估对于改善患者预后具有重要意义。肌钙蛋白(Cardiac Troponin, cTn)作为心肌细胞的关键调节蛋白,是心肌损伤的重要标志物;脑钠肽(Brain Natriuretic Peptide, BNP)主要由心脏分泌,反映心脏功能及代偿能力。本文综述了肌钙蛋白与脑钠肽的生物学特征及MINS的相关影响因素,并提出联合检测能显著提高MINS诊断的敏感性和特异性。通过同时监测心肌损伤与心功能变化,为临床早期诊断和及时干预提供了有力支持。Myocardial injury after non cardiac surgery (MINS) is a common complication during the perioperative period, and its diagnosis and evaluation are of great significance for improving patient prognosis. Cardiac troponin (cTn), as a key regulatory protein of myocardial cells, its release is an important biomarker of myocardial injury. Brain Natriuretic Peptide (BNP) is mainly secreted by the heart, reflecting cardiac function and compensatory ability. This article reviews the biological characteristics of troponin and brain natriuretic peptide, as well as the related influencing factors of MINS. It proposes that combined detection can significantly improve the sensitivity and specificity of MINS diagnosis. By simultaneously monitoring myocardial injury and changes in heart function, it provides strong support for early clinical diagnosis and timely intervention.
