The balance between immunostimulation and immunoregulation in T cell immunity is achieved by maintaining specific ratios of Thl, Th2, Th3 and Trl cells. Here, we investigate levels of type 1 （IFN-gamma; NK1）, type 2...The balance between immunostimulation and immunoregulation in T cell immunity is achieved by maintaining specific ratios of Thl, Th2, Th3 and Trl cells. Here, we investigate levels of type 1 （IFN-gamma; NK1）, type 2 （IL-13; NK2）, type 3 （TGF-beta; NK3） and regulatory （IL-10; NKr） cytokines in peripheral blood to assess the cytokine profiles of natural killer （NK） cells following human allogeneic hematopoietic stem cell transplantation （allo-HSCT）. NK2 and NK3 cell expansion was observed after aUo-HSCT; levels of NKr ceils reached donor levels at day 15, though levels of NK1 cells were consistently lower than donor levels until day 60 after allo-HSCT. Multivariate analysis showed that a higher level of NK1 cells by day 15 was associated with a lower overall risk of acute graft-versus-host disease （GVHD） （HR 0.157, P=-0.010） as well as II-IV acute GVHD （HR 0.260, P=-0.059）. Furthermore, higher levels of NK1 cells by day 15 were correlated with lower rates of cytomegalovirus （CMV） reactivation （HR 0.040, 0.005-0.348,/9=-0.003）. These results indicate that rapid reconstitution of NK cells, especially NK1 cells, can help prevent the development of GVHD as well as CMV reactivation after allogeneic transplantation.展开更多
Constitutional consciousness is a general term for citizens＇ knowledge, opinions, ideas and thinking about the Constitution. It not only drives the implementation of the Constitution and the development of democratic...Constitutional consciousness is a general term for citizens＇ knowledge, opinions, ideas and thinking about the Constitution. It not only drives the implementation of the Constitution and the development of democratic politics and the rule of law, but also serves as an indicator for the extent of the rule of law. In the course of social change, constitutional consciousness constitutes an inner spiritual force within the constitutional order. It is a force for change in itself, especially as ＂a cultural soft power＂ that remolds normative judgments and value bases. A stable and mature constitutional consciousness provides a foundation for the benign operation of social change. Over the past 60 years, the development of Chinese society has followed a tortuous path, but due to citizens＇ constitutional consciousness the 1954 and 1982 Constitutions were always vehicles and forces for social cohesion and harmony. The way to improve supervision of constitutional implementation is to truly make rule of law thinking centered on constitutional consciousness into the basic value consensus of citizens and different groups at the level of the nation, the government and society. Adhering to the concept of the supremacy of the Constitution and exploring ways and means of adopting a more reasonable, pragmatic and open approach to its implementation will provide a solid constitutional foundation for the full implementation of governing the country according to law and will advance the construction of a rule of law China.展开更多
基金supported by the National Natural Science Foundation of China (81270644, 81670166, 81230013, 81530046)the Beijing Talents fund (2015000021223ZK26)+2 种基金the Major State Basic Research Development Program of China (2013CB733700)the Foundation for Innovative Research Groups of the National Natural Science Foundation of China (81621001)supported by the Collaborative Innovation Center of Hematology, China
文摘The balance between immunostimulation and immunoregulation in T cell immunity is achieved by maintaining specific ratios of Thl, Th2, Th3 and Trl cells. Here, we investigate levels of type 1 （IFN-gamma; NK1）, type 2 （IL-13; NK2）, type 3 （TGF-beta; NK3） and regulatory （IL-10; NKr） cytokines in peripheral blood to assess the cytokine profiles of natural killer （NK） cells following human allogeneic hematopoietic stem cell transplantation （allo-HSCT）. NK2 and NK3 cell expansion was observed after aUo-HSCT; levels of NKr ceils reached donor levels at day 15, though levels of NK1 cells were consistently lower than donor levels until day 60 after allo-HSCT. Multivariate analysis showed that a higher level of NK1 cells by day 15 was associated with a lower overall risk of acute graft-versus-host disease （GVHD） （HR 0.157, P=-0.010） as well as II-IV acute GVHD （HR 0.260, P=-0.059）. Furthermore, higher levels of NK1 cells by day 15 were correlated with lower rates of cytomegalovirus （CMV） reactivation （HR 0.040, 0.005-0.348,/9=-0.003）. These results indicate that rapid reconstitution of NK cells, especially NK1 cells, can help prevent the development of GVHD as well as CMV reactivation after allogeneic transplantation.
基金a phased result of Research on the 30th Anniversary of the Implementation of the Constitution,a program of the Humanities and Social Sciences Planning Fund,Ministry of Education(No.11YJA820021)
文摘Constitutional consciousness is a general term for citizens＇ knowledge, opinions, ideas and thinking about the Constitution. It not only drives the implementation of the Constitution and the development of democratic politics and the rule of law, but also serves as an indicator for the extent of the rule of law. In the course of social change, constitutional consciousness constitutes an inner spiritual force within the constitutional order. It is a force for change in itself, especially as ＂a cultural soft power＂ that remolds normative judgments and value bases. A stable and mature constitutional consciousness provides a foundation for the benign operation of social change. Over the past 60 years, the development of Chinese society has followed a tortuous path, but due to citizens＇ constitutional consciousness the 1954 and 1982 Constitutions were always vehicles and forces for social cohesion and harmony. The way to improve supervision of constitutional implementation is to truly make rule of law thinking centered on constitutional consciousness into the basic value consensus of citizens and different groups at the level of the nation, the government and society. Adhering to the concept of the supremacy of the Constitution and exploring ways and means of adopting a more reasonable, pragmatic and open approach to its implementation will provide a solid constitutional foundation for the full implementation of governing the country according to law and will advance the construction of a rule of law China.
