Blueberry muffin baby is a descriptive term for purpuric lesions reflective of extramedullary hematopoeisis. The clinical lesions most commonly result from intrauterine infections, such as rubella and cytomegalovirus,...Blueberry muffin baby is a descriptive term for purpuric lesions reflective of extramedullary hematopoeisis. The clinical lesions most commonly result from intrauterine infections, such as rubella and cytomegalovirus, and less commonlywith malignancy and hematologic disorders. Langerhans cell histiocytosis is a clonal proliferation of dendritic histiocytes in the skin. This has very rarely been associated with a blueberry muffin presentation. We report the case of a newborn with typical lesions of cutaneous hematopoiesis and lytic bone lesions related to Langerhans cell histiocytosis. At birth, approximately 40 2mm to 5 mm purpuric, nonblanchingmacules were scattered on the trunk, extremities, and soles of our patient. Laboratory studies were unremarkable and cultures were negative. Skin biopsy showed a dermal proliferation of histiocytes staining positive for S100 and Cd1a. Pediatric bone surveys, chest radiographs, and computed tomography scans of the head were normal. Six months later, the skin lesions had resolved, but radiographs revealed lytic bone lesions of the right tibia, right ilium, and left pubic ramus, consistent with skeletal Langerhans cell histiocytosis.展开更多
英语是世界历史上使用最广泛的一种语言。每七人中就有一人说英语。世界上半数以上的书籍和四分之三的国际邮件是用英语写的。在所有的语言中英语的词汇量最大,英语单词几乎多达两百万个,它是最为宏伟壮观的文学的载体之一。然而,英语...英语是世界历史上使用最广泛的一种语言。每七人中就有一人说英语。世界上半数以上的书籍和四分之三的国际邮件是用英语写的。在所有的语言中英语的词汇量最大,英语单词几乎多达两百万个,它是最为宏伟壮观的文学的载体之一。然而,英语却是一种非常古怪的语言。让我们来看一些可笑的例子:在eggplant(茄子)里并没有egg(鸡蛋);在pine apple (菠萝)里既没有pine(松树),也没有apple(苹果);在ham-burger(汉堡包)里并无ham(火腿),汉堡包其实是用碎牛肉做的。English muffins(英国松饼)并非英国发明,French展开更多
文摘Blueberry muffin baby is a descriptive term for purpuric lesions reflective of extramedullary hematopoeisis. The clinical lesions most commonly result from intrauterine infections, such as rubella and cytomegalovirus, and less commonlywith malignancy and hematologic disorders. Langerhans cell histiocytosis is a clonal proliferation of dendritic histiocytes in the skin. This has very rarely been associated with a blueberry muffin presentation. We report the case of a newborn with typical lesions of cutaneous hematopoiesis and lytic bone lesions related to Langerhans cell histiocytosis. At birth, approximately 40 2mm to 5 mm purpuric, nonblanchingmacules were scattered on the trunk, extremities, and soles of our patient. Laboratory studies were unremarkable and cultures were negative. Skin biopsy showed a dermal proliferation of histiocytes staining positive for S100 and Cd1a. Pediatric bone surveys, chest radiographs, and computed tomography scans of the head were normal. Six months later, the skin lesions had resolved, but radiographs revealed lytic bone lesions of the right tibia, right ilium, and left pubic ramus, consistent with skeletal Langerhans cell histiocytosis.
文摘英语是世界历史上使用最广泛的一种语言。每七人中就有一人说英语。世界上半数以上的书籍和四分之三的国际邮件是用英语写的。在所有的语言中英语的词汇量最大,英语单词几乎多达两百万个,它是最为宏伟壮观的文学的载体之一。然而,英语却是一种非常古怪的语言。让我们来看一些可笑的例子:在eggplant(茄子)里并没有egg(鸡蛋);在pine apple (菠萝)里既没有pine(松树),也没有apple(苹果);在ham-burger(汉堡包)里并无ham(火腿),汉堡包其实是用碎牛肉做的。English muffins(英国松饼)并非英国发明,French
