A class of core-shell-type fluorescent nanospheres with a particle diameter less than 40 nm,which emit orange,yellow,green and cyan light,respectively,were prepared.In fabricating strategy,the water-insoluble,photo-th...A class of core-shell-type fluorescent nanospheres with a particle diameter less than 40 nm,which emit orange,yellow,green and cyan light,respectively,were prepared.In fabricating strategy,the water-insoluble,photo-thermostable fluorescent dye molecules are molecularly dispersed and embedded in the nanoscale crosslinked polymeric matrix via a modified miniemulsion polymerization process,and then the biocompatible shells are achieved by a seeded polymerization technique.These obtained nanospheres are uniform in size,highly photostable,of high chemical resistance and high fluorescence quantum-yield.展开更多
Nanoparticles with typical core-shell structure were prepared with a blend of methoxypoly（ethylene glycol）-poly（lactide） copolymer （MPEG-PLA） and poly （lactic acid） （PLA） along with paclitaxel by the O/W sol...Nanoparticles with typical core-shell structure were prepared with a blend of methoxypoly（ethylene glycol）-poly（lactide） copolymer （MPEG-PLA） and poly （lactic acid） （PLA） along with paclitaxel by the O/W solvent evaporation method. An orthogonal experiment L9（3）3 was applied to get the best preparation conditions. The core-shell paclitaxel-loaded MPEG-PLA/PLA nanoparticles with the highest drug loading efficiency were obtained when amount of MPEG-PLA, time of ultrasonication and volume of deionized water were 300 mg, 10 rain and 30 mL, respectively. The release behavior of paclitaxel from the optimal MPEG-PLA/PLA nanoparticles showed that 22% ofpaclitaxel was released in 14 d. When incubating with human nasopharyngeal carcinoma ceils expressing LMP 1, these optimal nanoparticles showed a little lower tumor growth compared with free paclitaxel.展开更多
基金supported by the National Natural Science Foundation of China(21201085)Natural Science Foundation of Jiangsu Province,China(BK2012294)Jiangsu University College Student Scientific Research Project,China(Y11A018)~~
文摘A class of core-shell-type fluorescent nanospheres with a particle diameter less than 40 nm,which emit orange,yellow,green and cyan light,respectively,were prepared.In fabricating strategy,the water-insoluble,photo-thermostable fluorescent dye molecules are molecularly dispersed and embedded in the nanoscale crosslinked polymeric matrix via a modified miniemulsion polymerization process,and then the biocompatible shells are achieved by a seeded polymerization technique.These obtained nanospheres are uniform in size,highly photostable,of high chemical resistance and high fluorescence quantum-yield.
基金Key Research Foundation of Wannan Medical College(Grant No.WK2014Z06)Doctoral Starting-up Foundation of Wannan Medical College(Grant No.201219)
文摘Nanoparticles with typical core-shell structure were prepared with a blend of methoxypoly（ethylene glycol）-poly（lactide） copolymer （MPEG-PLA） and poly （lactic acid） （PLA） along with paclitaxel by the O/W solvent evaporation method. An orthogonal experiment L9（3）3 was applied to get the best preparation conditions. The core-shell paclitaxel-loaded MPEG-PLA/PLA nanoparticles with the highest drug loading efficiency were obtained when amount of MPEG-PLA, time of ultrasonication and volume of deionized water were 300 mg, 10 rain and 30 mL, respectively. The release behavior of paclitaxel from the optimal MPEG-PLA/PLA nanoparticles showed that 22% ofpaclitaxel was released in 14 d. When incubating with human nasopharyngeal carcinoma ceils expressing LMP 1, these optimal nanoparticles showed a little lower tumor growth compared with free paclitaxel.
