目的:探讨体重指数(body mass index,BMI)对多囊卵巢综合征(polycystic ovarian syndrome,PCOS)患者体外受精-胚胎移植(invitrofertilization-embryotransfer,IVF-ET)卵子及胚胎质量的影响。方法:回顾性分析2020年7月—2023年7月在银川...目的:探讨体重指数(body mass index,BMI)对多囊卵巢综合征(polycystic ovarian syndrome,PCOS)患者体外受精-胚胎移植(invitrofertilization-embryotransfer,IVF-ET)卵子及胚胎质量的影响。方法:回顾性分析2020年7月—2023年7月在银川市妇幼保健院行拮抗剂方案促排的PCOS患者共229个周期,其中正常体重组为对照组,共130个周期,超重及肥胖组为研究组,共89个周期。比较两组患者的一般基础资料、控制性超促排卵指标及实验室指标。结果:研究组患者的促性腺激素(gonadotropin,Gn)启量、总量及天数均高于对照组患者,差异均有统计学意义(P<0.05)。研究组患者的正常受精率低于对照组患者,差异有统计学意义(P<0.05)。结论:超重及肥胖可能对PCOS患者进行IVF-ET的卵子及胚胎质量产生负面影响。展开更多
Objective: To report on the first successful pregnancy performing preimplantation genetic diagnosis (PGD) on embryos obtained after combining natural IVF with in vitro maturation procedure. Design: Case report. Settin...Objective: To report on the first successful pregnancy performing preimplantation genetic diagnosis (PGD) on embryos obtained after combining natural IVF with in vitro maturation procedure. Design: Case report. Setting: University hospital. Patient(s): A 35- year-old patient with polycystic ovaries who was attending the fertility clinic. Intervention(s): In vitro maturation of immature oocytes and preimplantation genetic diagnosis. Main Outcome Measure(s): Preimplantation genetic diagnosis of aneuploidy screening in embryos produced from in vitro maturation procedure. Result(s): Thirteen immature and two mature oocytes were collected, and eight mature oocytes were normally fertilized, of which six embryos were biopsied for chromosome analysis. Two chromosomally normal embryos were transferred on day 5, resulting in the birth of a healthy child. Conclusion(s): This case report demonstrates that an acceptable number of embryos can be generated after in vitro maturation procedure to perform PGD for aneuploidy screening and that this approach can be extended to patients with polycystic ovaries or polycystic ovary syndrome who are undergoing PGD for other genetic diseases.展开更多
文摘目的:探讨体重指数(body mass index,BMI)对多囊卵巢综合征(polycystic ovarian syndrome,PCOS)患者体外受精-胚胎移植(invitrofertilization-embryotransfer,IVF-ET)卵子及胚胎质量的影响。方法:回顾性分析2020年7月—2023年7月在银川市妇幼保健院行拮抗剂方案促排的PCOS患者共229个周期,其中正常体重组为对照组,共130个周期,超重及肥胖组为研究组,共89个周期。比较两组患者的一般基础资料、控制性超促排卵指标及实验室指标。结果:研究组患者的促性腺激素(gonadotropin,Gn)启量、总量及天数均高于对照组患者,差异均有统计学意义(P<0.05)。研究组患者的正常受精率低于对照组患者,差异有统计学意义(P<0.05)。结论:超重及肥胖可能对PCOS患者进行IVF-ET的卵子及胚胎质量产生负面影响。
文摘Objective: To report on the first successful pregnancy performing preimplantation genetic diagnosis (PGD) on embryos obtained after combining natural IVF with in vitro maturation procedure. Design: Case report. Setting: University hospital. Patient(s): A 35- year-old patient with polycystic ovaries who was attending the fertility clinic. Intervention(s): In vitro maturation of immature oocytes and preimplantation genetic diagnosis. Main Outcome Measure(s): Preimplantation genetic diagnosis of aneuploidy screening in embryos produced from in vitro maturation procedure. Result(s): Thirteen immature and two mature oocytes were collected, and eight mature oocytes were normally fertilized, of which six embryos were biopsied for chromosome analysis. Two chromosomally normal embryos were transferred on day 5, resulting in the birth of a healthy child. Conclusion(s): This case report demonstrates that an acceptable number of embryos can be generated after in vitro maturation procedure to perform PGD for aneuploidy screening and that this approach can be extended to patients with polycystic ovaries or polycystic ovary syndrome who are undergoing PGD for other genetic diseases.
