Purpose: To correlate retinal circulatory measurements using scanning laser fl uorescein angiography and flow velocities of retrobulbar vessels measured by mea ns of colour Doppler imaging. Methods: Fifteen patients w...Purpose: To correlate retinal circulatory measurements using scanning laser fl uorescein angiography and flow velocities of retrobulbar vessels measured by mea ns of colour Doppler imaging. Methods: Fifteen patients with normal pressure gla ucoma (NPG) and 15 healthy volunteers underwent colour Doppler imaging and fluor escein angiographic studies. Peak systolic velocities (PSVs), end-diastolic velocities (EDVs) and resistive indices (RIs) of the ophthalmic artery (OA) an d central retinal artery were obtained. In the fluorescein angiograms arterioven ous passage time (AVP) was quantified by means of digital dye dilution curve ana lysis. Results: Arteriovenous passage time was significantly prolonged in NPG pa tients compared to healthy subjects (P=0.0026). In the central retinal artery PS V (P=0.023) and EDV (P < 0.0001) were significantly decreased and RI was increas ed (P < 0.0001) in patients with NPG. The EDV of the central retinal artery show ed a significant correlation with AVP (EDV: r=-0.53, P=0.0023). The RI of the c entral retinal artery correlated significantly to AVP (RI: r= 0.63, P< 0.0001). The AVP did not correlate to EDV or PSV, nor to the RI measured in the ophthalmi c artery. Conclusion: Arteriovenous passage time, which represents blood flow in a vascular segment of artery, capillary bed and corresponding vein, was found t o be correlated to the EDV and the RI of the central retinal artery. The combina tion of different techniques allows further interpretation of ocular circulatory responses.展开更多
文摘Purpose: To correlate retinal circulatory measurements using scanning laser fl uorescein angiography and flow velocities of retrobulbar vessels measured by mea ns of colour Doppler imaging. Methods: Fifteen patients with normal pressure gla ucoma (NPG) and 15 healthy volunteers underwent colour Doppler imaging and fluor escein angiographic studies. Peak systolic velocities (PSVs), end-diastolic velocities (EDVs) and resistive indices (RIs) of the ophthalmic artery (OA) an d central retinal artery were obtained. In the fluorescein angiograms arterioven ous passage time (AVP) was quantified by means of digital dye dilution curve ana lysis. Results: Arteriovenous passage time was significantly prolonged in NPG pa tients compared to healthy subjects (P=0.0026). In the central retinal artery PS V (P=0.023) and EDV (P < 0.0001) were significantly decreased and RI was increas ed (P < 0.0001) in patients with NPG. The EDV of the central retinal artery show ed a significant correlation with AVP (EDV: r=-0.53, P=0.0023). The RI of the c entral retinal artery correlated significantly to AVP (RI: r= 0.63, P< 0.0001). The AVP did not correlate to EDV or PSV, nor to the RI measured in the ophthalmi c artery. Conclusion: Arteriovenous passage time, which represents blood flow in a vascular segment of artery, capillary bed and corresponding vein, was found t o be correlated to the EDV and the RI of the central retinal artery. The combina tion of different techniques allows further interpretation of ocular circulatory responses.
