Dihydroxy-6-methyldeoxybenzoin synthesized from the Hoesch reaction of 3,5-dihydroxytoluene with benzyl cyanide was used to react with triethyl orthoformate by using morpholine as catalyst to form 5-methyl-7-hydroxy-i...Dihydroxy-6-methyldeoxybenzoin synthesized from the Hoesch reaction of 3,5-dihydroxytoluene with benzyl cyanide was used to react with triethyl orthoformate by using morpholine as catalyst to form 5-methyl-7-hydroxy-isoflavone. The latter gave the title compound via O-methylation with dimethyl sulfate. The yields of the three steps were 55%, 87% and 56%, respectively. The total yield was about 26%.展开更多
文摘Dihydroxy-6-methyldeoxybenzoin synthesized from the Hoesch reaction of 3,5-dihydroxytoluene with benzyl cyanide was used to react with triethyl orthoformate by using morpholine as catalyst to form 5-methyl-7-hydroxy-isoflavone. The latter gave the title compound via O-methylation with dimethyl sulfate. The yields of the three steps were 55%, 87% and 56%, respectively. The total yield was about 26%.
