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N-(2’,3’,4’,6’-四乙酰基-β-D-吡喃葡萄糖基)-5-(4’-甲基联苯基-2-基)四氮唑的合成 被引量:3
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作者 安礼涛 曾润生 +1 位作者 刘传芹 邹建平 《苏州科技学院学报(自然科学版)》 CAS 2003年第1期17-21,共5页
5-(4’-甲基联苯基-2-基)四氮唑与2,3,4,6-四乙酰基-α-D-吡喃溴代葡萄糖在弱碱性条件下反应生成了β型的氮糖苷。产物结构经红外光谱、核磁共振光谱、质谱和元素分析得到了证实。
关键词 N-(2’ 3’ 4’ 6’-四乙酰基-β-D-吡喃葡萄糖基)-5-(4’-甲基联苯基-2-基)四 合成 氮糖苷 2 3 4 6-四乙酰基-α-D-吡喃溴代葡萄糖 5-(4’-甲基联苯基-2-基)四 弱碱性
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2-脱氧-2-氨基-β-D-吡喃葡萄糖氮苷的合成
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作者 周俊 郭振楚 《合成化学》 CAS CSCD 2008年第2期186-188,共3页
通过Schmidt糖苷化反应,合成了2个新化合物2-脱氧-2-氨基-β-D-吡喃葡萄糖氮苷,其结构经1H NMR,IR和元素分析表征。
关键词 氨基葡萄糖 氮糖苷 三氯乙酰亚胺酸酯 咪唑 合成
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氨基糖苷类药物的抗菌后效应和新的给药方案 被引量:1
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作者 周晨霞 陈川 《实用临床医药杂志》 CAS 2008年第5期122-124,共3页
氨基糖苷类抗生素为半合成抗生素,水溶性好,性质稳定,抗菌谱广,对葡萄球菌属、需氧革兰阴性杆菌等具良好的抗菌活性等特点。然而,该类药物的治疗浓度范围比较窄,不良反应较常见,其中有些还是不可逆毒性,因此限制了它在临床的广... 氨基糖苷类抗生素为半合成抗生素,水溶性好,性质稳定,抗菌谱广,对葡萄球菌属、需氧革兰阴性杆菌等具良好的抗菌活性等特点。然而,该类药物的治疗浓度范围比较窄,不良反应较常见,其中有些还是不可逆毒性,因此限制了它在临床的广泛使用。如何合理安全使用氨基糖苷类,避免不良反应成为抗感染化疗领域的热点。 展开更多
关键词 糖苷 每日单次给药 抗菌后效应
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1-苯基-3-(2′,3′,4′,6′-四乙酰基-β-D-吡喃型葡萄糖基)-5-苯基-2,4-咪唑啉二酮的合成 被引量:1
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作者 邢兴龙 张健 邹建平 《苏州大学学报(自然科学版)》 CAS 2003年第2期101-104,114,共5页
1,5-二苯基-2,4-咪唑啉二酮与2,3,4,6-四乙酰基-α D 吡喃型溴代葡萄糖在弱碱性条件下反应生成了β型的氮糖苷.产物结构经红外光谱、核磁共振光谱、质谱和元素分析得到了证实.
关键词 1-苯基-3-(2' 3’ 4' 6’-四乙酰基-β-D-吡喃型葡萄糖基)-5-苯基-2 4-咪唑啉二酮 合成 氮糖苷 结构表征
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Facile synthesis of a core trisaccharide of laminin as a potential metastatic antagonist
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作者 金晓锋 孟祥豹 +2 位作者 廖凯俊 李庆 李中军 《Journal of Chinese Pharmaceutical Sciences》 CAS 2008年第4期272-276,共5页
A core trisaccharide of laminin, β-D-Gal-(1→4)-β-D-GlcpNAc-(1→6)-α-D-Manp-OMe, with potential anti-rumor metastatic activity was designed and prepared. 2-Iodoglactosyl azide was used as the donor to construct... A core trisaccharide of laminin, β-D-Gal-(1→4)-β-D-GlcpNAc-(1→6)-α-D-Manp-OMe, with potential anti-rumor metastatic activity was designed and prepared. 2-Iodoglactosyl azide was used as the donor to construct 2-N-acetamido-2-deoxylactosyl moiety through an azidoiodo-glycosylation reaction. Simultaneously, 1, 2-trans-β-glycosic bond was formed stereoselectively in one step with a moderate yield. This novel procedure avoided the use of 2-amino-2-deoxyglucose as both donor and acceptor. 展开更多
关键词 Azidoiodo-glycosylation Lactal 2-Iodoglycosyl azide Lactosamine
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Soil Microbial Activity During Secondary Vegetation Succession in Semiarid Abandoned Lands of Loess Plateau 被引量:13
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作者 JIANG Jin-Ping XIONG You-Cai +3 位作者 JIANG Hong-Mei YE De-You SONG Ya-Jie LI Feng-Min 《Pedosphere》 SCIE CAS CSCD 2009年第6期735-747,共13页
To show the vegetation succession interaction with soil properties, microbial biomass, basal respiration, and enzyme activities in different soil layers (0-60 cm) were determined in six lands, i.e., 2-, 7-, 11-, 20-... To show the vegetation succession interaction with soil properties, microbial biomass, basal respiration, and enzyme activities in different soil layers (0-60 cm) were determined in six lands, i.e., 2-, 7-, 11-, 20-, and 43-year-old abandoned lands and one native grassland, in a semiarid hilly area of the Loess Plateau. The results indicated that the successional time and soil depths affected soil microbiological parameters significantly. In 20-cm soil layer, microbial biomass carbon (MBC), microbial biomass nitrogen (MBN), MBC/MBN, MBC to soil organic carbon ratio (MBC/SOC), and soil basal respiration tended to increase with successional stages but decrease with soil depths. In contrast, metabolic quotient (qCO2) tended to decrease with successional stages but increase with soil depths. In addition, the activities of urease, catalase, neutral phosphatase, β-fructofuranosidase, and earboxymethyl cellulose (CMC) enzyme increased with successional stages and soil depths. They were significantly positively correlated with microbial biomass and SOC (P 〈 0.5), whereas no obvious trend was observed for the polyphenoloxidase activity. The results indicated that natural vegetation succession could improve soil quality and promote ecosystem restoration, but it needed a long time under local climate conditions. 展开更多
关键词 microbial biomass carbon microbial biomass nitrogen SOC soil enzyme activity
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Effect of Bu-Zhong-Yi-Qi-Tang on deficiency of N-glycan/nitric oxide and islet damage induced by streptozotocin in diabetic rats
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作者 xiao-Qiu Liu Ling Wu Xue-Jun Guo 《World Journal of Gastroenterology》 SCIE CAS CSCD 2009年第14期1730-1737,共8页
AIM: To investigate the effect of Bu-Zhong-Yi-Qi-Tang (Decoction for Reinforcing Middle Jiao and Replenishing Qi) on deficiency of N-glycan/nitric oxide (NO) and islet damage induced by injecting two medium doses of s... AIM: To investigate the effect of Bu-Zhong-Yi-Qi-Tang (Decoction for Reinforcing Middle Jiao and Replenishing Qi) on deficiency of N-glycan/nitric oxide (NO) and islet damage induced by injecting two medium doses of streptozotocin (STZ). METHODS: Diabetes was induced by intraperitoneal injection of STZ at 55 mg/kg on day 1 and day 8. Islet damage was evaluated using a scoring system. Nitrite, nitrate, α-mannosidase and amylase activities were measured by colorimetry. N-glycan patterns of amylase were determined with lectin [ConA, pisum sativum agglutinin (PSA), peanut agglutinin (PNA), and lens culinaris agglutinin (LCA)] affinity precipitation method. RESULTS: Severe islet necrosis and mild islet atrophy were observed in diabetic rats. The number and size ofislets, the activities of α-mannosidase, amylase and nitrite were decreased, while the binding of PNA and LCA to amylase was increased. All of which were improved after treatment with Bu-Zhong-Yi-Qi-Tang. Islet damage was significantly correlated with nitrite, nitrate, α-mannosidase, amylase and the binding of LCA, PNA, and PSA to amylase.CONCLUSION: STZ-induced islet damage is related to N-glycan deficiency in proteins by blocking α-mannosidase activity and no deficiency, accumulation of unfolded proteins, and endoplasmic reticulum stress and activation of cellular signals, all of which are improved after treatment with Bu-Zhong-YiQi-Tang. 展开更多
关键词 N-Giycan Nitric oxide Diabetic rats Isletdamage Alpha mannosidase Bu-Zhong-Yi-Qi-Tang
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Synthesis of N(OMe)-linked TF antigen analogue
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作者 孙爽 刘燕燕 +3 位作者 曹亚飞 牛有红 李勤 叶新山 《Journal of Chinese Pharmaceutical Sciences》 CAS CSCD 2015年第6期356-363,共8页
Tumor-associated carbohydrate antigens (TACAs), important molecular markers on tumor cells, are major targets for the development of anti-cancer vaccines. However, due to the immunotolerance and weak immunogenicity,... Tumor-associated carbohydrate antigens (TACAs), important molecular markers on tumor cells, are major targets for the development of anti-cancer vaccines. However, due to the immunotolerance and weak immunogenicity, native TACAs cannot induce powerful immune response. The use of modified TACAs such as N-glycosides could be an alternative strategy to overcome this problem. Herein, the synthesis of N(OMe)-linked analogue of tumor-associated disaccharide antigen Thomsen-Friedenreich (TF) by the glycosylation reaction is described. 展开更多
关键词 Tumor-associated carbohydrate antigen TF N-glycoside GLYCOSYLATION CARBOHYDRATE
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Effect of Honghua (Flos Carthami) on nitric oxide production in RAW 264.7 cells and α-glucosidase activity 被引量:2
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作者 Hui Liao Linda Banbury +4 位作者 Hongping Liang Xiaomin Wang Xiaokai Lü Ling Hu Jin Wu 《Journal of Traditional Chinese Medicine》 SCIE CAS CSCD 2014年第3期362-368,共7页
OBJECTIVE: To study the effects of extracts from Honghua (Flos Carthaml~ on lipopolysaccharide in- duced nitric oxide (NO) production in RAW 264.7 cells and the influence of the extracts on yeast a-glucosidase act... OBJECTIVE: To study the effects of extracts from Honghua (Flos Carthaml~ on lipopolysaccharide in- duced nitric oxide (NO) production in RAW 264.7 cells and the influence of the extracts on yeast a-glucosidase activity. The total flavonoid content of the extracts was also determined. METHODS: Cytotoxicity of the extracts to RAW 264.7 cells was evaluated by the ATPliteTM method. Inhibitory effects of the extracts on NO production were evaluated by Griess assay. Curcumin was used as a positive control. Screening of extracts for po- tential a-glucosidase inhibitors was done by a fiuo- rometric assay. The assay was based on the hydroly- sis of 4-methylumbelliferyl-a-D-glucopyranoside toform the fluorescent product, 4-methylumbellifer- one. Acarbose was used as a positive control. The total t3avonoid content was tested using kaempfer- ol as the standard. RESULTS: There were significant inhibitory effects on NO production when the extracts were 25-100 μg/ mL (P〈0.05) and curcumin was 2-4 μg/mL (P〈 0.001). The extracts showed an inhibitory effect on a-glucosidase activity at the concentrations of 15.6-125 μg/mL with a half maximal (50%)inhibito- ry concentration (ICs0) of (32.8± 5.7) μg/mL, com- pared with the ICs0 of acarbose at (1.8±0.4) μg/mL. There was a significant difference between the two IC50 values (P〈0.001). The total content of flavo- noids per gram of dried herb was 1.14 mg. CONCLUSION: Honghua (Flos Carthami) showed in- hibitory effects on NO production in activated RAW 264.7 macrophage cells and an inhibitory effect on yeast a-glucosidase. There might be a relationship between these pharmacological effects and its fla- vonoid content. 展开更多
关键词 Carthamus tinctorius Nitric oxide AI-pha-glucosidases FLAVONOIDS RAW 264.7 cells
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