In recent years, the researches on the theory and application of public articles and mechanism design at home and abroad has attracted more and more attentions. The paper uses the idea of mechanism design and simulati...In recent years, the researches on the theory and application of public articles and mechanism design at home and abroad has attracted more and more attentions. The paper uses the idea of mechanism design and simulation to analyze and solve environmental pollution improvement. By establishing a simple environmental pollution improvement model, the paper transforms pollution control into binary decision established by a sewage treatment plant and different decisions by the fisherman on the establishment of sewage treatment plants. The paper observes the results of applying different mechanisms and proposes the suggestions of implementin~ various pollution control methods.展开更多
Drug administration customized to individual cells could intrinsically address cancer heterogeneity and provide a safe and effective method for delivering personalized treatment. To accomplish this, we developed a sma...Drug administration customized to individual cells could intrinsically address cancer heterogeneity and provide a safe and effective method for delivering personalized treatment. To accomplish this, we developed a smart nanodrug delivery system characterized by cancer cell-targeted drug delivery and intracellular biomarker-responsive drug activation. This system was composed of a long-nicked DNA duplex formed by tandem hybridization of two extended antisense oligonucleotides whose ends were separately blocked with a cancer cell-specific aptamer, AS1411,and a replaceable anti-biomarker probe(ABP). We demonstrated that this DNA nanodrug was directed to cancer cells with the guidance power of AS 1411 and then activated by the presence of a given intracellular biomarker. By using such a belt-and-braces strategy, this DNA nanodrug system could safely and efficiently accelerate apoptosis of target cancer cells. Moreover, since the expression level of biomarkers tends to indicate the specific physiological state of individual cells, biomarker-responsive activation of the nanodrug is expected to enable customized drug administration at the cellular level.展开更多
文摘In recent years, the researches on the theory and application of public articles and mechanism design at home and abroad has attracted more and more attentions. The paper uses the idea of mechanism design and simulation to analyze and solve environmental pollution improvement. By establishing a simple environmental pollution improvement model, the paper transforms pollution control into binary decision established by a sewage treatment plant and different decisions by the fisherman on the establishment of sewage treatment plants. The paper observes the results of applying different mechanisms and proposes the suggestions of implementin~ various pollution control methods.
基金supported by the National Natural Science Foundation of China(21505039,2013CB932702)the China National Instrumentation Program(2011YQ03012412)the National Institutes of Health grants(GM079359,CA133086)
文摘Drug administration customized to individual cells could intrinsically address cancer heterogeneity and provide a safe and effective method for delivering personalized treatment. To accomplish this, we developed a smart nanodrug delivery system characterized by cancer cell-targeted drug delivery and intracellular biomarker-responsive drug activation. This system was composed of a long-nicked DNA duplex formed by tandem hybridization of two extended antisense oligonucleotides whose ends were separately blocked with a cancer cell-specific aptamer, AS1411,and a replaceable anti-biomarker probe(ABP). We demonstrated that this DNA nanodrug was directed to cancer cells with the guidance power of AS 1411 and then activated by the presence of a given intracellular biomarker. By using such a belt-and-braces strategy, this DNA nanodrug system could safely and efficiently accelerate apoptosis of target cancer cells. Moreover, since the expression level of biomarkers tends to indicate the specific physiological state of individual cells, biomarker-responsive activation of the nanodrug is expected to enable customized drug administration at the cellular level.
