In the case of composite girders, an effective cooperation of both parts of the section is influenced by deformability of connectors. Limited flexural stiffness of welded studs, used commonly in bridge structures, doe...In the case of composite girders, an effective cooperation of both parts of the section is influenced by deformability of connectors. Limited flexural stiffness of welded studs, used commonly in bridge structures, does not provide full interaction of a steel beam and a concrete slab. This changes strain distribution in cross-sections of a composite girder and results in redistribution of internal forces in steel and concrete element. In the paper partial interaction index defined on the basis of a neutral axis position, which can be used for verification of steel-concrete interaction in real bridge structures rather than in specimens is proposed. The range of the index value changes, obtained during load testing of a typical steel-concrete composite beam bridge, is presented. The investigation was carried out on a motorway viaduct, consisting of two parallel structures. During the testing values of strains in girders under static and quasi-static loads were measured. The readings from the gauges were used to determine the index, characterizing composite action of the girders. Results of bridge testing under movable load, changing position along the bridge span is presented and obtained in-situ influence functions of strains and index values are commented in the paper.展开更多
Objective The resting-state functional magnetic resonance imaging(rs-f MRI)method was used to observe brain activity and its functional connection upon electroacupuncture stimulation at bilateral uterine acupoints(EX-...Objective The resting-state functional magnetic resonance imaging(rs-f MRI)method was used to observe brain activity and its functional connection upon electroacupuncture stimulation at bilateral uterine acupoints(EX-CA1),as well as to investigate the mechanism of acupuncture in the treatment of gynecological diseases.Methods Twenty-two healthy female subjects were stimulated by electroacupuncture at bilateral uterine acupoints;rs-f MRI data of the brain were acquired and standardized.Degree centrality(DC),amplitude of low-frequency fluctuation(ALFF),and regional homogeneity(ReHo)were used to analyze local spontaneous brain activity via acupuncture.An independent component analysis was used to evaluate the functional connectivity of the resting brain networks after acupuncture.Results Analytical results showed that the neural activity intensity of the precuneus lobe,orbitofrontal cortex,lingual gyrus,amygdala,and posterior central gyrus decreased after acupuncture(voxel P<0.001,cluster P<0.05).Functional connectivity analysis revealed weakened auditory and right frontal-parietal networks(voxel P<0.001,cluster P<0.05),enhanced visual network(voxel P<0.001,cluster P<0.05),and synergistic auditory network and hypothalamic-pituitary system.Conclusion Significant differences in neural activity and functional connectivity in specific brain regions were observed after acupuncture intervention at uterine acupoints;the hypothalamic-pituitary system also showed various active states in different brain regions.It is speculated that the effective mechanism of acupuncture at uterine acupoints is related to the regulation of reproductive hormones,emotional changes,and somatic sensations.Therefore,the methods used in this study could clarify the neural mechanism of uterine-point acupuncture in the treatment of gynecological diseases and may serve as a reference for other studies pertaining to acupuncture.展开更多
In topology optimization of structures considering flexibility, degenerated optimal solutions, such as hinges, gray areas and disconnected structures may appear. In this paper, built upon the newly developed morphable...In topology optimization of structures considering flexibility, degenerated optimal solutions, such as hinges, gray areas and disconnected structures may appear. In this paper, built upon the newly developed morphable component based topology optimization approach, a novel representation using connected morphable components(CMC) and a linkage scheme are proposed to prevent degenerating designs and to ensure structure integrity. A lower bound condition of the thickness of each component is also incorporated to completely remove the smallest components in an optimal configuration. Designs of flexible structures, such as compliant mechanism design, maximum compliance structure design, and design of low-frequency resonating micro devices are studied to validate the proposed methodology. Our work demonstrates that the new methodology can successfully prevent degeneration solutions and possesses other advantages, such as minimum member size control in topology optimization of flexible structures.展开更多
文摘In the case of composite girders, an effective cooperation of both parts of the section is influenced by deformability of connectors. Limited flexural stiffness of welded studs, used commonly in bridge structures, does not provide full interaction of a steel beam and a concrete slab. This changes strain distribution in cross-sections of a composite girder and results in redistribution of internal forces in steel and concrete element. In the paper partial interaction index defined on the basis of a neutral axis position, which can be used for verification of steel-concrete interaction in real bridge structures rather than in specimens is proposed. The range of the index value changes, obtained during load testing of a typical steel-concrete composite beam bridge, is presented. The investigation was carried out on a motorway viaduct, consisting of two parallel structures. During the testing values of strains in girders under static and quasi-static loads were measured. The readings from the gauges were used to determine the index, characterizing composite action of the girders. Results of bridge testing under movable load, changing position along the bridge span is presented and obtained in-situ influence functions of strains and index values are commented in the paper.
基金National Nature Science Foundation of China(61872225)Natural Science Foundation of Shandong Province(ZR2020KF013,ZR2020ZD44,ZR2019ZD04,and ZR2020QF043)+1 种基金Introduction and Cultivation Program for Young Creative Talents in Colleges and Universities of Shandong Province(2019-173)Special Fund of Qilu Health and Health Leading Talents Training Project。
文摘Objective The resting-state functional magnetic resonance imaging(rs-f MRI)method was used to observe brain activity and its functional connection upon electroacupuncture stimulation at bilateral uterine acupoints(EX-CA1),as well as to investigate the mechanism of acupuncture in the treatment of gynecological diseases.Methods Twenty-two healthy female subjects were stimulated by electroacupuncture at bilateral uterine acupoints;rs-f MRI data of the brain were acquired and standardized.Degree centrality(DC),amplitude of low-frequency fluctuation(ALFF),and regional homogeneity(ReHo)were used to analyze local spontaneous brain activity via acupuncture.An independent component analysis was used to evaluate the functional connectivity of the resting brain networks after acupuncture.Results Analytical results showed that the neural activity intensity of the precuneus lobe,orbitofrontal cortex,lingual gyrus,amygdala,and posterior central gyrus decreased after acupuncture(voxel P<0.001,cluster P<0.05).Functional connectivity analysis revealed weakened auditory and right frontal-parietal networks(voxel P<0.001,cluster P<0.05),enhanced visual network(voxel P<0.001,cluster P<0.05),and synergistic auditory network and hypothalamic-pituitary system.Conclusion Significant differences in neural activity and functional connectivity in specific brain regions were observed after acupuncture intervention at uterine acupoints;the hypothalamic-pituitary system also showed various active states in different brain regions.It is speculated that the effective mechanism of acupuncture at uterine acupoints is related to the regulation of reproductive hormones,emotional changes,and somatic sensations.Therefore,the methods used in this study could clarify the neural mechanism of uterine-point acupuncture in the treatment of gynecological diseases and may serve as a reference for other studies pertaining to acupuncture.
基金supported by the National Science Foundation (Grant Nos. CMMI-1130948 & CMMI-1334929)
文摘In topology optimization of structures considering flexibility, degenerated optimal solutions, such as hinges, gray areas and disconnected structures may appear. In this paper, built upon the newly developed morphable component based topology optimization approach, a novel representation using connected morphable components(CMC) and a linkage scheme are proposed to prevent degenerating designs and to ensure structure integrity. A lower bound condition of the thickness of each component is also incorporated to completely remove the smallest components in an optimal configuration. Designs of flexible structures, such as compliant mechanism design, maximum compliance structure design, and design of low-frequency resonating micro devices are studied to validate the proposed methodology. Our work demonstrates that the new methodology can successfully prevent degeneration solutions and possesses other advantages, such as minimum member size control in topology optimization of flexible structures.
