OBJECTIVE To analyze the expression and levels of serum proinflammatory cytokines including tumor necrosis factor alpha （TNF-α）, and interleukin （IL）-6 in patients with hepatocellular carcinoma （HCC）, who recei...OBJECTIVE To analyze the expression and levels of serum proinflammatory cytokines including tumor necrosis factor alpha （TNF-α）, and interleukin （IL）-6 in patients with hepatocellular carcinoma （HCC）, who received orthotopic liver transplantation （OLT）.METHODS The blood samples of 20 consecutive HCC patients who underwent liver transplantation were detected and analyzed for the clinical serum biochemical parameters, TNF-α and IL-6.Blood samples were drawn from the radial artery at planned time points： preoperatively, intraoperatively, and postoperatively.Levels of serum TNF-α and IL-6 were detected with enzymelinked immunosorbent assay （ELISA）.RESULTS The levels of serum TNF-αand IL-6 increased significantly at reperfusion phase compared with those detected preoperatively （P 〈 0.01）, and the level of serum IL-6 remained significantly higher until the third day after the liver transplantation. There was a significant correlation between TNF-αand IL-6 （P〈0.001）.CONCLUSION This research into the effects of the proinflammatory cytokines on liver transplantation has provided new insights into the mechanisms of ischemia and reperfusion injury to OLT.展开更多
休克的本质为组织氧供不能维持正常组织代谢,因此纠正组织缺氧是休克治疗的中心内容.临床中虽然全身循环和灌注指标如全身氧输送(DO2)、心输出量(CO)、血压、乳酸、碱剩余等已经达到正常,但组织缺氧可能仍持续存在[1],因此把缺氧的监测...休克的本质为组织氧供不能维持正常组织代谢,因此纠正组织缺氧是休克治疗的中心内容.临床中虽然全身循环和灌注指标如全身氧输送(DO2)、心输出量(CO)、血压、乳酸、碱剩余等已经达到正常,但组织缺氧可能仍持续存在[1],因此把缺氧的监测从整体深入到局部、从全身水平深入到组织层面是临床迫切的需要.在这种情况下,经皮氧分压(transcutaneous partial pressure of oxygen,PtcO2)监测作为反映组织水平代谢的指标逐渐被危重病学者重视.本文将探讨经PtcO2监测在反映组织灌注和缺氧代谢方面的意义.展开更多
文摘OBJECTIVE To analyze the expression and levels of serum proinflammatory cytokines including tumor necrosis factor alpha （TNF-α）, and interleukin （IL）-6 in patients with hepatocellular carcinoma （HCC）, who received orthotopic liver transplantation （OLT）.METHODS The blood samples of 20 consecutive HCC patients who underwent liver transplantation were detected and analyzed for the clinical serum biochemical parameters, TNF-α and IL-6.Blood samples were drawn from the radial artery at planned time points： preoperatively, intraoperatively, and postoperatively.Levels of serum TNF-α and IL-6 were detected with enzymelinked immunosorbent assay （ELISA）.RESULTS The levels of serum TNF-αand IL-6 increased significantly at reperfusion phase compared with those detected preoperatively （P 〈 0.01）, and the level of serum IL-6 remained significantly higher until the third day after the liver transplantation. There was a significant correlation between TNF-αand IL-6 （P〈0.001）.CONCLUSION This research into the effects of the proinflammatory cytokines on liver transplantation has provided new insights into the mechanisms of ischemia and reperfusion injury to OLT.
文摘休克的本质为组织氧供不能维持正常组织代谢,因此纠正组织缺氧是休克治疗的中心内容.临床中虽然全身循环和灌注指标如全身氧输送(DO2)、心输出量(CO)、血压、乳酸、碱剩余等已经达到正常,但组织缺氧可能仍持续存在[1],因此把缺氧的监测从整体深入到局部、从全身水平深入到组织层面是临床迫切的需要.在这种情况下,经皮氧分压(transcutaneous partial pressure of oxygen,PtcO2)监测作为反映组织水平代谢的指标逐渐被危重病学者重视.本文将探讨经PtcO2监测在反映组织灌注和缺氧代谢方面的意义.
