Objective Recently,there has been growing interest in the interaction between depressive disorders and pain.The purpose of this study was to examine whether depression would lead to a decreased sensitivity to noxious ...Objective Recently,there has been growing interest in the interaction between depressive disorders and pain.The purpose of this study was to examine whether depression would lead to a decreased sensitivity to noxious stimuli in rats with spontaneous pain.Methods The olfactory bulbectomized rats were used as a model of depression.The depression-like behaviors were assessed by open field test and changes in body weight.Formalin solution was injected into the rat hindpaw to produce ongoing pain.Noxious thermal stimuli were applied onto the hindpaw contralateral to formalin injection,and the withdrawal thresholds were measured.Results In non-depressive rats,the formalin-treated paw developed hypoalgesia to noxious stimuli while the contralateral paw was not affected.The depressive rats,however,showed a significantly lower sensitivity to noxious thermal stimulus,represented as higher withdrawal thresholds of the contralateral paw,when compared to the non-depressive rats.Conclusion These results demonstrate that depression can alleviate the stimulus-evoked pain even in the context of formalin inflammatory pain,consistent with the previous clinical observations that patients suffering from both depression and persistent pain have decreased sensitivities to noxious experimental stimuli.展开更多
文摘目的比较圈套器冷切除术(cold snare polypectomy,CSP)与圈套器热切除术(hot snare polypectomy,HSP)在治疗直径4~9 mm无蒂结直肠息肉中的疗效。方法选取2021年6月至2021年11月在首都医科大学附属北京朝阳医院西院区消化科行内镜下息肉切除的187例患者,共284例息肉,其中145例息肉采用CSP治疗,139例息肉采用HSP治疗。本研究主要评价指标为息肉的完整切除率,次要评价指标为标本回收率、操作时间、治疗费用及住院时间,并发症包括术中出血率、迟发出血率及穿孔率。结果CSP组的完整切除率为90.34%,HSP组为92.09%,两组差异无统计学意义(P=0.336)。在术中出血方面,CSP组发生7例,HSP组发生5例,两组差异无统计学意义(P=0.606)。CSP组发生迟发出血1例,HSP组无迟发出血。两组均未发生穿孔。所有息肉切除所获标本均成功收回。CSP组平均操作时间短于HSP组(70.6 s vs 75.2 s,P<0.001)。CSP组治疗平均费用低于HSP组(1371.00元vs 2434.90元,P<0.001)。CSP组平均住院时间短于HSP组(2.9 d vs 3.6 d,P<0.001)。结论CSP与HSP同样为切除直径4~9 mm无蒂结直肠息肉安全、有效的治疗方式,但CSP操作更省时,患者花费更少、住院时间更短。
基金supported by the grants from National Natural Science Foundation of China(No.30700223,30770688,30970959)Beijing Natural Science Foundation(No.5082008)+2 种基金the 100 Talented Plan of the Chinese Academy of Sciencesthe National Hi-Tech Research and Development Program of China(No.2008AA022604)NIH Fogarty International Center(R03-TW 008038)
文摘Objective Recently,there has been growing interest in the interaction between depressive disorders and pain.The purpose of this study was to examine whether depression would lead to a decreased sensitivity to noxious stimuli in rats with spontaneous pain.Methods The olfactory bulbectomized rats were used as a model of depression.The depression-like behaviors were assessed by open field test and changes in body weight.Formalin solution was injected into the rat hindpaw to produce ongoing pain.Noxious thermal stimuli were applied onto the hindpaw contralateral to formalin injection,and the withdrawal thresholds were measured.Results In non-depressive rats,the formalin-treated paw developed hypoalgesia to noxious stimuli while the contralateral paw was not affected.The depressive rats,however,showed a significantly lower sensitivity to noxious thermal stimulus,represented as higher withdrawal thresholds of the contralateral paw,when compared to the non-depressive rats.Conclusion These results demonstrate that depression can alleviate the stimulus-evoked pain even in the context of formalin inflammatory pain,consistent with the previous clinical observations that patients suffering from both depression and persistent pain have decreased sensitivities to noxious experimental stimuli.
