By analyzing the observed phenomena and the data collected in the study, a multi-compartment linear circulation model for targeting drug delivery system was developed and the function formulas of the drug concentratio...By analyzing the observed phenomena and the data collected in the study, a multi-compartment linear circulation model for targeting drug delivery system was developed and the function formulas of the drug concentration-time in blood and target organ by computing were figured out. The drug concentration-time curve for target organ can be plotted with reference to the data of drug concentration in blood according to the model. The pharmacokinetic parameters of the drug in target organ could also be obtained. The practicability of the model was further checked by the curves of drug concentration-time in blood and target organ(liver) of liver-targeting nanoparticles in animal tests. Based on the liver drug concentration-time curves calculated by the function formula of the drug in target organ, the pharmacokinetic behavior of the drug in target organ(liver) was analyzed by statistical moment, and its pharmacokinetic parameters in liver were obtained. It is suggested that the (relative targeting index( can be used for quantitative evaluation of the targeting drug delivery systems.展开更多
In order to control the dust pollution produced by air leg rock drill in the trolley area during the excavation of long-distance single ended tunnel,the full-scale physical model of working face was established by usi...In order to control the dust pollution produced by air leg rock drill in the trolley area during the excavation of long-distance single ended tunnel,the full-scale physical model of working face was established by using FLUENT software,and the numerical simulation analysis of tunnel drilling ventilation and dust removal parameters was carried out.The results show that it is difficult to control the dust pollution of the face by conventional ventilation,and the drilling dust is distributed in the range of 10 m from the face;after the introduction of the long pressure and short suction ventilation scheme,when the ratio of compressed air volume to exhaust air volume is 0.72,the height of the pressure fan is 2.5 m,the distance between the pressure fan and the palm face is 20 m,and the exhaust fan is 12 m away from the palm,the dust concentration control efficiency of the working face is increased by about 60%.Therefore,in the similar long-distance single head tunnel construction,it is appropriate to adopt the dust removal method of long-distance short suction and exhaust fan to ensure the working environment.展开更多
To model Skeletonema costatum blooms and their relationship with environmental parameters in situ, a S. costatum-specific zero-dimensional box model based on the mechanistic model Eco3M was established using physiolog...To model Skeletonema costatum blooms and their relationship with environmental parameters in situ, a S. costatum-specific zero-dimensional box model based on the mechanistic model Eco3M was established using physiological features. The parameters were calibrated using experimental counterparts, and simulations were compared with published laboratory findings. The resulting normalized objective function （NOF） values are less than 1.0 （and in most cases less than 0.58） and the values for the slope y （between 0.656 7-1.127 4） and R2 （between 0.806 8-0.971） are close to 1.0 for most of the sub-figures. This indicates good agreement between simulated and measured data and suggests that the model reproduces the general characteristics of S. costatum growth and use of nutrients under different N- or P-limiting conditions. The model is appropriate for further applications and can be used to test more scenarios using other nutrients.展开更多
The variations of ocean environmental parameters invariably result in variations of local modal wave numbers of a sound pressure field. The asymptotic Hankel transform with a short sliding window is applied to the com...The variations of ocean environmental parameters invariably result in variations of local modal wave numbers of a sound pressure field. The asymptotic Hankel transform with a short sliding window is applied to the complex sound pressure field in the water containing a mesoscale eddy to examine the variation of local modal wave numbers in such a range-dependent environment. The numerical simulation results show that modal wave number spectra obtained by this method can reflect the location and strength of a mesoscale eddy, therefore it can be used to monitor the strength and spatial scale of ocean mesoscale eddies.展开更多
This paper uses the hardware with ZigBee standard and communication protocol, it consists of wireless sensor network in the greenhouse that can timely sample temperature, humidity, collection of environmental paramete...This paper uses the hardware with ZigBee standard and communication protocol, it consists of wireless sensor network in the greenhouse that can timely sample temperature, humidity, collection of environmental parameters. At the same time, this design uses the GPRS module, the data will be collected through the Internet and send to the PC server, and can receive control instructions from the host computer, through the adjustment of agricultural facilities valve to reverse control environment parameters.展开更多
Madden-Julian Oscillations (MJO) in six integrations using an AGCM with different cumulus parameterization schemes and resolutions are examined to investigate their impacts on the MJO simulation. Results suggest that ...Madden-Julian Oscillations (MJO) in six integrations using an AGCM with different cumulus parameterization schemes and resolutions are examined to investigate their impacts on the MJO simulation. Results suggest that the MJO simulation can be affected by both resolution and cumulus parameterization, though the latter, which determines the fundamental ability of the AGCM in simulating the MJO and the characteristics of the simulated MJO, is more crucial than the former. Model resolution can substantially affect the simulated MJO in certain aspects. Increasing resolution cannot improve the simulated MJO substantially, but can significantly modulate the detailed character of the simulated MJO; meanwhile, the impacts of resolution are dependent on the cumulus parameterization, determining the basic features of the MJO. Changes in the resolution do not alter the nature of the simulated MJO but rather regulate the simulation itself, which is constrained by cumulus parameterization schemes. Therefore, the vertical resolution needs to be increased simultaneously. The vertical profile of diabatic heating may be a crucial factor that is responsible for these different modeling results. To a large extent, it is determined by the cumulus parameterization scheme used.展开更多
The present work is concerned with the characterization of hardening parameters for an elasto-plastic continuum model, taking into account the memory effect of plastic strain amplitude, in order to predict the hystere...The present work is concerned with the characterization of hardening parameters for an elasto-plastic continuum model, taking into account the memory effect of plastic strain amplitude, in order to predict the hysteretic responses of a ferritic steel. This elasto-plastic three-dimensional model is based on the internal thermodynamic variables which composed of the nonlinear kinematic hardening and isotropic hardening with the plastic strain memorization. The emphasis is put on the determination of strain memory parameters along with other material parameters of the proposed model in order to better simulate the behavior of the material at different strain range. The material parameters are calibrated with the experimental stabilized loops of stress-strain curves available in the literature. The predicted stabilized loops from the simulation with the determined parameters show good agreement with the experimental results signifying the validity of the considered model.展开更多
By taking the surface chemical reactions as the rate-controlling step, a possible reaction mechanism for ethylene epoxidation to synthesize ethylene oxide over the A-type silver catalyst was developed, while it was as...By taking the surface chemical reactions as the rate-controlling step, a possible reaction mechanism for ethylene epoxidation to synthesize ethylene oxide over the A-type silver catalyst was developed, while it was assumed that the epoxidation reaction would take place between ethylene and the un-dissociated adsorbed oxygen O2 a on the solo active sites, while the deep oxidation would occur between ethylene and the dissociated adsorbed oxygen Oa on the adjacent multi-active sites. In order to describe the effect of 1,2-C2H4Cl2(EDC) inhibitor on the ethylene epoxidation process, the reversible reactions between EDC and vinyl chloride(VC) on the active sites of silver catalyst was introduced. According to the assumed mechanism, the hyperbolic macro-kinetic model of ethylene epoxidation over the A-type silver catalyst was established, and the macrokinetic experiments were carried out in an internal-recycle gradientless reactor operating at a pressure of 2.1 MPa and a temperature in the range of 217.8—249.0 ℃, with the gas composition(molar fraction) consisting of 15.82%—34.65% C2H4, 2.55%—7.80% O2, 0.88%—6.15% CO2, 0.15—2.61 μmol/mol of 1,2-C2H4Cl2 and 0.14—1.28 μmol/mol of C2H3 Cl. By means of the Simplex Optimal Method, the parameters of the macrokinetic models were estimated. Statistical test showed that the macrokinetic models developed for the A-type silver catalyst agree well with the experimental results.展开更多
In this paper, we consider three species harvesting model and develop a solution proce- dure which is able to calculate the equilibrium points of the model where some biological parameters of the model are interval nu...In this paper, we consider three species harvesting model and develop a solution proce- dure which is able to calculate the equilibrium points of the model where some biological parameters of the model are interval numbers. A parametric mathematical program is formulated to find the biological equilibrium of the model for different values of parame- ters. This interval-valued problem is converted into equivalent crisp model using interval operations. The main advantage of the proposed procedure is that we can present dif- ferent characteristics of the model in a single framework. Analytically, the existence of steady state and stabilities are looked into. Using mathematical software, the model is illustrated and the results are obtained and presented in tabular and graphical forms.展开更多
文摘By analyzing the observed phenomena and the data collected in the study, a multi-compartment linear circulation model for targeting drug delivery system was developed and the function formulas of the drug concentration-time in blood and target organ by computing were figured out. The drug concentration-time curve for target organ can be plotted with reference to the data of drug concentration in blood according to the model. The pharmacokinetic parameters of the drug in target organ could also be obtained. The practicability of the model was further checked by the curves of drug concentration-time in blood and target organ(liver) of liver-targeting nanoparticles in animal tests. Based on the liver drug concentration-time curves calculated by the function formula of the drug in target organ, the pharmacokinetic behavior of the drug in target organ(liver) was analyzed by statistical moment, and its pharmacokinetic parameters in liver were obtained. It is suggested that the (relative targeting index( can be used for quantitative evaluation of the targeting drug delivery systems.
基金Project(51874016)supported by the National Natural Science Foundation of China。
文摘In order to control the dust pollution produced by air leg rock drill in the trolley area during the excavation of long-distance single ended tunnel,the full-scale physical model of working face was established by using FLUENT software,and the numerical simulation analysis of tunnel drilling ventilation and dust removal parameters was carried out.The results show that it is difficult to control the dust pollution of the face by conventional ventilation,and the drilling dust is distributed in the range of 10 m from the face;after the introduction of the long pressure and short suction ventilation scheme,when the ratio of compressed air volume to exhaust air volume is 0.72,the height of the pressure fan is 2.5 m,the distance between the pressure fan and the palm face is 20 m,and the exhaust fan is 12 m away from the palm,the dust concentration control efficiency of the working face is increased by about 60%.Therefore,in the similar long-distance single head tunnel construction,it is appropriate to adopt the dust removal method of long-distance short suction and exhaust fan to ensure the working environment.
基金Supported by the National Natural Science Foundation of China(Nos.40821004,41276186)the Knowledge Innovation Program of Chinese Academy of Sciences(No.KZCX2-YW-Q07-02)
文摘To model Skeletonema costatum blooms and their relationship with environmental parameters in situ, a S. costatum-specific zero-dimensional box model based on the mechanistic model Eco3M was established using physiological features. The parameters were calibrated using experimental counterparts, and simulations were compared with published laboratory findings. The resulting normalized objective function （NOF） values are less than 1.0 （and in most cases less than 0.58） and the values for the slope y （between 0.656 7-1.127 4） and R2 （between 0.806 8-0.971） are close to 1.0 for most of the sub-figures. This indicates good agreement between simulated and measured data and suggests that the model reproduces the general characteristics of S. costatum growth and use of nutrients under different N- or P-limiting conditions. The model is appropriate for further applications and can be used to test more scenarios using other nutrients.
文摘The variations of ocean environmental parameters invariably result in variations of local modal wave numbers of a sound pressure field. The asymptotic Hankel transform with a short sliding window is applied to the complex sound pressure field in the water containing a mesoscale eddy to examine the variation of local modal wave numbers in such a range-dependent environment. The numerical simulation results show that modal wave number spectra obtained by this method can reflect the location and strength of a mesoscale eddy, therefore it can be used to monitor the strength and spatial scale of ocean mesoscale eddies.
文摘This paper uses the hardware with ZigBee standard and communication protocol, it consists of wireless sensor network in the greenhouse that can timely sample temperature, humidity, collection of environmental parameters. At the same time, this design uses the GPRS module, the data will be collected through the Internet and send to the PC server, and can receive control instructions from the host computer, through the adjustment of agricultural facilities valve to reverse control environment parameters.
基金National Natural Science Foundation of China (40805027 40675051)
文摘Madden-Julian Oscillations (MJO) in six integrations using an AGCM with different cumulus parameterization schemes and resolutions are examined to investigate their impacts on the MJO simulation. Results suggest that the MJO simulation can be affected by both resolution and cumulus parameterization, though the latter, which determines the fundamental ability of the AGCM in simulating the MJO and the characteristics of the simulated MJO, is more crucial than the former. Model resolution can substantially affect the simulated MJO in certain aspects. Increasing resolution cannot improve the simulated MJO substantially, but can significantly modulate the detailed character of the simulated MJO; meanwhile, the impacts of resolution are dependent on the cumulus parameterization, determining the basic features of the MJO. Changes in the resolution do not alter the nature of the simulated MJO but rather regulate the simulation itself, which is constrained by cumulus parameterization schemes. Therefore, the vertical resolution needs to be increased simultaneously. The vertical profile of diabatic heating may be a crucial factor that is responsible for these different modeling results. To a large extent, it is determined by the cumulus parameterization scheme used.
文摘The present work is concerned with the characterization of hardening parameters for an elasto-plastic continuum model, taking into account the memory effect of plastic strain amplitude, in order to predict the hysteretic responses of a ferritic steel. This elasto-plastic three-dimensional model is based on the internal thermodynamic variables which composed of the nonlinear kinematic hardening and isotropic hardening with the plastic strain memorization. The emphasis is put on the determination of strain memory parameters along with other material parameters of the proposed model in order to better simulate the behavior of the material at different strain range. The material parameters are calibrated with the experimental stabilized loops of stress-strain curves available in the literature. The predicted stabilized loops from the simulation with the determined parameters show good agreement with the experimental results signifying the validity of the considered model.
文摘By taking the surface chemical reactions as the rate-controlling step, a possible reaction mechanism for ethylene epoxidation to synthesize ethylene oxide over the A-type silver catalyst was developed, while it was assumed that the epoxidation reaction would take place between ethylene and the un-dissociated adsorbed oxygen O2 a on the solo active sites, while the deep oxidation would occur between ethylene and the dissociated adsorbed oxygen Oa on the adjacent multi-active sites. In order to describe the effect of 1,2-C2H4Cl2(EDC) inhibitor on the ethylene epoxidation process, the reversible reactions between EDC and vinyl chloride(VC) on the active sites of silver catalyst was introduced. According to the assumed mechanism, the hyperbolic macro-kinetic model of ethylene epoxidation over the A-type silver catalyst was established, and the macrokinetic experiments were carried out in an internal-recycle gradientless reactor operating at a pressure of 2.1 MPa and a temperature in the range of 217.8—249.0 ℃, with the gas composition(molar fraction) consisting of 15.82%—34.65% C2H4, 2.55%—7.80% O2, 0.88%—6.15% CO2, 0.15—2.61 μmol/mol of 1,2-C2H4Cl2 and 0.14—1.28 μmol/mol of C2H3 Cl. By means of the Simplex Optimal Method, the parameters of the macrokinetic models were estimated. Statistical test showed that the macrokinetic models developed for the A-type silver catalyst agree well with the experimental results.
文摘In this paper, we consider three species harvesting model and develop a solution proce- dure which is able to calculate the equilibrium points of the model where some biological parameters of the model are interval numbers. A parametric mathematical program is formulated to find the biological equilibrium of the model for different values of parame- ters. This interval-valued problem is converted into equivalent crisp model using interval operations. The main advantage of the proposed procedure is that we can present dif- ferent characteristics of the model in a single framework. Analytically, the existence of steady state and stabilities are looked into. Using mathematical software, the model is illustrated and the results are obtained and presented in tabular and graphical forms.
